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Generation of Drosophila enhancer-trap lines expressing a GAL4 transcriptional activator and their use in the study of Drosophila neurobiology

Objective



Enhancer-trapping in the fruitfly Drosophila is a versatile
approach for generation of cell markers and isolation of developmentally regulated genes. A recent variant of the approach,
P-GAL4 enhancer-trapping, allows in principle the expression of any cloned gene in virtually any cell type. First, we will
generate several thousand P-GAL4 enhancer-trap fly lines and make them generally available to the Drosophila research community; this resource will be of particular use to the European fly
community. Second, we will use many of the lines generated for collaborative work in developmental neurobiology. At a later date, these enchancer-trap lines may also be of use for fly
genome mapping.

Topic(s)

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Call for proposal

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Coordinator

University of Warwick
EU contribution
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Address
Gibbet Hill Road
CV4 7AL Coventry
United Kingdom

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Total cost
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Participants (2)