Objective This project aims to unite global efforts to target the highly druggable class of enzymes called cyclic nucleotide phosphodiesterases (PDEs) in the fight for neglected parasitic diseases (NPD). It will establish a drug discovery platform, PDE4NPD, that combines phenotypic screening with efficient target-centric drug discovery, including target validation, various strategies for compound screening, PDE hit and lead optimization, safety and toxicology assessments and evaluation of anti-parasitic activity. The platform will make use of the target class expertise that the participating SMEs have gained when developing drugs for human and parasite PDEs, while all public partners offer proven experience in the field of NPD. The SMEs will adopt and progress existing PDE inhibitors that are in different stages of the drug discovery pipeline (i.e. target validation, hit and lead optimization). The current portfolio of inhibitors have clinical potential for treating sleeping sickness, Chagas' disease and leishmaniasis. Finding novel hits and leads for the PDEs that are associated with helminth diseases is also foreseen. The platform is open for targeting other NPD, and a broad panel of phenotypic screens (including malaria) is available to test PDE inhibitors. The phenotypic screening is performed by world-renowned groups, including two institutes in endemic countries. By capturing human and parasite PDE-related data in annotated chemogenomics databases, PDE-4-NPD will achieve the knowledge accumulation that is typical for target-centric approaches, thereby making the NPD drug development more efficient and enabling the SMEs to take advantage of the molecular understanding that is key for developing new medicines. The PDE4NPD platform constitutes an ideal basis for creating fruitful collaborations with both public and private partners word-wide. Fields of science medical and health sciencesclinical medicinepsychiatrysleep disordersmedical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesmathematicspure mathematicsmathematical analysisdifferential equationspartial differential equations Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2013.2.3.4-2 - Drug development for neglected parasitic diseases Call for proposal FP7-HEALTH-2013-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator STICHTING VU EU contribution € 1 215 666,00 Address DE BOELELAAN 1105 1081 HV Amsterdam Netherlands See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Rob Leurs (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF GLASGOW United Kingdom EU contribution € 786 759,00 Address UNIVERSITY AVENUE G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Administrative Contact Joe Galloway (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IOTA Pharmaceuticals Ltd United Kingdom EU contribution € 545 156,00 Address COWLEY ROAD ST JOHNS INNOVATION CENTRE CB4 0WS Cambridge See on map Region East of England East Anglia Cambridgeshire CC Administrative Contact Paul England (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF KENT United Kingdom EU contribution € 787 968,00 Address THE REGISTRY CANTERBURY CT2 7NZ Canterbury, Kent See on map Region South East (England) Kent East Kent Activity type Higher or Secondary Education Establishments Administrative Contact Andrew Massoura (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data European ScreeningPort GmbH Participation ended Germany EU contribution € 31 654,72 Address Schnackenburgallee 22525 Hamburg See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Sheraz Gul (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 398 664,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Ana Maria De La Fuente (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Theodor Bilharz Research Institute Egypt EU contribution € 299 938,00 Address El Nil street 12411 Giza See on map Activity type Research Organisations Administrative Contact Amr Radwan (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITEIT ANTWERPEN Belgium EU contribution € 778 548,00 Address PRINSSTRAAT 13 2000 Antwerpen See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Higher or Secondary Education Establishments Administrative Contact Anne Adams (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACAO OSWALDO CRUZ Brazil EU contribution € 199 419,00 Address AVENIDA BRASIL 4365 21040 900 Rio De Janeiro See on map Activity type Research Organisations Administrative Contact Maria De Nazaré Correia Soeiro (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING LYGATURE Netherlands EU contribution € 300 000,00 Address JAARBEURSPLEIN 6 3521 AL Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Other Administrative Contact Herman Verheij (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 656 227,28 Address HANSASTRASSE 27C 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Michael Prestele (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data