Objective Acute and chronic kidney disease is a worldwide medical and public health problem in all developped and undevelopped Countries. It is clear that a large part of the bad outcome of end-stage renal diseas (ESRD) patients is due to deficient follow-up during the earlier chronic kidney disease (CKD) stages.The concept that extracellular vesicles and exosomes (EVs) by transferring extracellular RNAs can modulate the phenotype of target cells is an emerging paradigm in the intercellular communication. The extracellular RNAs are thus now considered as paracrine/endocrine signals. EVs contain diverse species of RNAs (mRNA, miRNAs and long non-coding RNAs) reflecting the functional state of the cell of origin. Recent studies on adult stem cell-induced tissue regeneration pointed out paracrine/endocrine mechanisms rather than permanent engraftment and trans-differentiation of stem cells. Therefore, the paracrine/endocrine hypothesis has changed the perspective of the therapeutic use of stem cells in regenerative medicine. Additionally, several studies indicate that EVs play a relevant role as mediators of stem cell induced regeneration by reprogramming injured cells.Within this project, we will explore the different necessary aspects in order to get a more profound knowledge on EVs, on their mechanisms of action in tissue injury, and on the definition of the most promising “active biological ingredients” of their content to further promote EV as new potential therapeutic strategies in the field of regenerative medicine. Also, within the EVStemInjury project, two different approaches of EV production will be explored: Biological and Synthetic, showing the different potential design strategies and to assess their efficiency. Finally, in order to explore the renoprotective effect of EVs, developed within the project, ranging from toxic, ischemic and reperfusion models, we will use a large number of experimental in vitro as in vivo models of acute kidney injury. Fields of science medical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencescell biologymedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesgeneticsRNAmedical and health sciencesclinical medicinenephrologykidney diseases Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2013-IAPP - Marie Curie Action: "Industry-Academia Partnerships and Pathways" Call for proposal FP7-PEOPLE-2013-IAPP See other projects for this call Funding Scheme MC-IAPP - Industry-Academia Partnerships and Pathways (IAPP) Coordinator BIOINDUSTRY PARK SILVANO FUMERO SPA SOCIETA'BENEFIT EU contribution € 446 506,53 Address VIA RIBES 5 10010 Colleretto Giacosa Italy See on map Region Nord-Ovest Piemonte Torino Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Alberto Baldi (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all LONDON METROPOLITAN UNIVERSITY United Kingdom EU contribution € 300 427,81 Address HOLLOWAY ROAD 166 220 N7 8DB London See on map Region London Inner London — East Haringey and Islington Activity type Higher or Secondary Education Establishments Administrative Contact Jameel Inal (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITAIR MEDISCH CENTRUM UTRECHT Netherlands EU contribution € 191 513,53 Address HEIDELBERGLAAN 100 3584 CX Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Higher or Secondary Education Establishments Administrative Contact Raymond M Schiffelers (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Spain EU contribution € 216 776,91 Address CALLE ROSSELLO 149 PUERTA BJS 08036 Barcelona See on map Region Este Cataluña Barcelona Activity type Other Administrative Contact Pastora Martinez Samper (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FRESENIUS MEDICAL CARE ITALIA SPA Participation ended Italy EU contribution € 94 522,45 Address VIA CREMA 8 26020 PALAZZO PIGNANO See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ciro Tetta (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data