Objective The ABIRISK project provides an integrated approach to the study of immunization against biopharmaceuticals, bringing together a unique panel of experts from different disciplines. ABIRISK will involve many of the European leaders in rheumatology, gastroenterology, hemophilia and multiple sclerosis, caring for ~30,000 patients treated with biopharmaceuticals, with ~10,000 additional patients recruited per year. This should lead to the constitution of the largest possible cohort in Europe for the study of immunogenicity, a condition critical for the success of the program. ABIRISK will also benefit from the unique expertise of immunologist partners in the development of innovative strategies for predicting the immunogenicity of biopharmaceuticals and for defining its mechanisms. The large number of patients enrolled in the ABIRISK cohorts should make it possible to study the genetic basis of immunogenicity in a new way. We will standardize all clinical and biological information before its integration into a large database for evaluation of the clinical relevance of immunization against biopharmaceuticals and stratification of the risk to patients as a function of factors linked to treatment or to the individual. Computational biology and biostatistical modeling will be used to develop models for predicting immunogenicity that will be validated with the ABIRISK database.The complementarity between the clinical partners from different disciplines, immunologists, methodologists and biostatisticians will create a unique task force for studies of biopharmaceutical immunogenicity. The direct outcomes of the proposed work will be greater understanding of the mechanisms involved in the emergence of anti-drug antibodies, the development of new methods for predicting immunogenicity and a comprehensive view of the respective value of predictive tools, and guidelines for the development of new biopharmaceuticals and patient care. Fields of science medical and health sciencesclinical medicinerheumatologynatural sciencescomputer and information sciencesdatabasesmedical and health sciencesbasic medicineimmunologyimmunisationmedical and health sciencesbasic medicineneurologymultiple sclerosismedical and health sciencesclinical medicinegastroenterology Programme(s) FP7-JTI - Specific Programme "Cooperation": Joint Technology Initiatives Topic(s) IMI-JU-03-2010-02 - Immunogenicity: Assessing The Clinical Relevance And Risk Minimization Of Antibodies To Biopharmaceuticals Call for proposal IMI-JU-03-2010 See other projects for this call Funding Scheme JTI-CP-IMI - Joint Technology Initiatives - Collaborative Project (IMI) Coordinator NOVARTIS PHARMA AG EU contribution No data Address LICHTSTRASSE 35 4056 Basel Switzerland See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Principal investigator Sebastian Spindeldreher (Dr.) Administrative Contact Barbara Stolz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (37) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 3 807 426,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Laurence PARMANTIER (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI FIRENZE Italy EU contribution € 610 139,00 Address Piazza San Marco 4 50121 Florence See on map Region Centro (IT) Toscana Firenze Activity type Higher or Secondary Education Establishments Administrative Contact CRISTINA DOLFI (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE PER L'ISTITUTO DI RICERCA IN BIOMEDICINA Switzerland EU contribution € 729 599,00 Address VIA FRANCESCO CHIESA 5 6500 Bellinzona See on map Region Schweiz/Suisse/Svizzera Ticino Ticino Activity type Research Organisations Administrative Contact Giorgio Noseda (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 739 970,00 Address RUE LEBLANC 25 75015 PARIS 15 See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact ELIANE DECK-CHAUMONT (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Biomonitor A/S Denmark EU contribution € 627 000,00 Address Fruebjergvej DK-2100 Copenhagen See on map Administrative Contact Marie Holde-Jensen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution € 1 683 976,00 Address GOWER STREET WC1E 6BT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACADEMISCH ZIEKENHUIS LEIDEN Netherlands EU contribution € 555 396,00 Address ALBINUSDREEF 2 2333 ZA Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact J. J. (John) Van Roozendaal (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 799 973,00 Address MEIBERGDREEF 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Erwin J. Van der Meijden (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO GIANNINA GASLINI Italy EU contribution € 422 175,00 Address VIA GEROLAMO GASLINI 5 16147 Genova See on map Region Nord-Ovest Liguria Genova Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Gabriella Marinari (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GROUPE D'ETUDES THERAPEUTIQUES DES AFFECTIONS INFLAMMATOIRES DIGESTIVES ASSOCIATION France EU contribution € 494 079,00 Address 2 RUE AMBROISE PARE 75010 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact JULIE DEMOLIN (Mme.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE HEALTH CORPORATION - RAMBAM Israel EU contribution € 151 883,00 Address HAALIYA 8 31096 Haifa See on map Activity type Research Organisations Administrative Contact Ronya Rubinstein (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM BONN Germany EU contribution € 536 309,00 Address VENUSBERG-CAMPUS 1 53127 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Becker (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL Germany EU contribution € 633 868,00 Address PAUL-EHRLICH-STRASSE 51-59 63225 Langen See on map Region Hessen Darmstadt Offenbach, Landkreis Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Stefanie Larisch (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN Germany EU contribution € 526 630,00 Address THEODOR W ADORNO PLATZ 1 60323 Frankfurt Am Main See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Christoph Königs (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Sweden EU contribution € 570 619,00 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Johan Forsslöf (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE UNIVERSITAT INNSBRUCK Austria EU contribution € 714 470,00 Address CHRISTOPH PROBST PLATZ 1 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Administrative Contact Florian Deisenhammer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HEINRICH-HEINE-UNIVERSITAET DUESSELDORF Germany EU contribution € 536 525,00 Address UNIVERSITAETSSTRASSE 1 40225 Dusseldorf See on map Region Nordrhein-Westfalen Düsseldorf Düsseldorf, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Thomas Dehmel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data REGION HOVEDSTADEN Denmark EU contribution € 306 812,00 Address KONGENS VAENGE 2 3400 Hillerod See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Per Soelberg Sorensen (PROF.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSSPITAL BASEL Switzerland EU contribution € 229 481,00 Address HEBELSTRASSE 32 4031 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Ludwig Kappos (MD) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA Spain EU contribution € 353 678,00 Address PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA 08035 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Lluis Masso (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data QUEEN MARY UNIVERSITY OF LONDON United Kingdom EU contribution € 261 905,00 Address 327 MILE END ROAD E1 4NS London See on map Region London Inner London — East Tower Hamlets Activity type Higher or Secondary Education Establishments Administrative Contact TANYA SZENDEFFY (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Germany EU contribution € 658 000,00 Address ISMANINGER STRASSE 22 81675 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Renate Rädlein (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 411 157,00 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Camille SEZE-GOIMIER (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ALTA RICERCA E SVILUPPO IN BIOTECNOLOGIE SRLU Italy EU contribution € 438 672,00 Address VIA FIORENTINA 151 53100 Siena See on map Region Centro (IT) Toscana Siena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Natascia Cannella (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data DRK-BLUTSPENDEDIENST BADEN-WURTTEMBERG-HESSEN GGMBH Germany EU contribution € 268 372,00 Address FRIEDRICH EBERT STRASSE 107 68167 Mannheim See on map Region Baden-Württemberg Karlsruhe Mannheim, Stadtkreis Activity type Research Organisations Administrative Contact Jörg Schüttrumpf (Dr.med.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERZITA KARLOVA Czechia EU contribution € 307 839,00 Address OVOCNY TRH 560/5 116 36 Praha 1 See on map Region Česko Praha Hlavní město Praha Activity type Higher or Secondary Education Establishments Administrative Contact Kristyna Matejkova (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PFIZER LIMITED United Kingdom EU contribution No data Address RAMSGATE ROAD CT13 9NJ Sandwich See on map Region South East (England) Kent East Kent Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Olga Krylova (Dr) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. United Kingdom EU contribution No data Address Great West Road 980 TW89GS Brentford See on map Region London Outer London — West and North West Hounslow and Richmond upon Thames Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Sally Miles (-) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UCB PHARMA SA Belgium EU contribution No data Address ALLEE DE LA RECHERCHE 60 1070 Bruxelles / Brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Simon Dresse (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France EU contribution No data Address 82 AVENUE RASPAIL 94250 GENTILLY See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nathalie PITON (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN Germany EU contribution No data Address FRANKFURTER STRASSE 250 64293 Darmstadt See on map Region Hessen Darmstadt Darmstadt, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ninog Péresse (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NOVO NORDISK A/S Denmark EU contribution No data Address NOVO ALLE 1 2880 Bagsvaerd See on map Region Danmark Hovedstaden Københavns omegn Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jørgen Dirach (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Bayer Pharma AG Germany EU contribution No data Address Muellerstrasse 178 13353 Berlin See on map Region Berlin Berlin Berlin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Petra Freitag (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IPSEN INNOVATION SAS France EU contribution No data Address AVENUE DU CANADA - ZONE INDUSTRIELLE DE COURTABOEUF 5 91940 Les Ulis See on map Region Ile-de-France Ile-de-France Essonne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Philippe Bardin (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDICAL RESEARCH INFRASTRUCTURE DEVELOPMENT AND HEALTH SERVICES FUND BY THE SHEBA MEDICAL CENTER Israel EU contribution € 12 680,00 Address TEL HASHOMER SHEBA MEDICAL CENTER 52621 Ramat Gan See on map Activity type Research Organisations Administrative Contact Eve Keret (Ms) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SciCross AB Sweden EU contribution € 345 958,00 Address GOTHIA SCIENCE PARK 54123 SKOVDE See on map Administrative Contact Pierre Dönnes (PhD) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 435 626,00 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Alix PILLOT (Mrs) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
