Objective The Chromosome 21 con sortium would like to increase the number of ressources available for mapping this chromosome and support the proposal of two groups from Russia: P 13 and P 14. The proposal of P 14 is to fill the gaps existing around the centromere and in the telometric region in the first generation map produced by P 5 in the preceding consortium (92-93) and by the CEPH-Genethon group: P 14 proposed to localize and characterize existing cosmid clones and produce new clones. Sequencing of these cosmids will also bring informations on the role of consensus centromeric or telemeric sequences. The proposal of P 13 is to participate to the construction of the transcriptional map: P13 has constructed a library of chromosome 21 heterogeneous nuclear c DNA (h nc DNA) and proposes to include this library in the list of libraries available to the consortium members. P 13 intends to produce new ETSs, to map mew genes and to isolate regulatory sequences located in gene introns. P 13 and P 14 would bring new ressources to the chromosome 21 consortium and would participate to the construction of an integrated genetic, physical and transcriptional map of chromosome 21. Programme(s) IC-PECO/COPERNICUS - Scientific and technological cooperation between the European Community and European non-member countries, 1992- Topic(s) 0202 - CEEC participation in BIOMEDICAL AND HEALTH RESEARCH programme (HUMAN GENOME) Call for proposal Data not available Funding Scheme CSC - Cost-sharing contracts Coordinator Centre National de la Recherche Scientifique EU contribution No data Address Rue de Sèvres 75743 Paris France See on map Total cost No data Participants (2) Sort alphabetically Sort by EU Contribution Expand all Collapse all NATIONAL RESEARCH CENTER OF MENTAL HEALTH - RUSSIAN ACADEMY OF MEDICAL SCIENCES Russia EU contribution No data Address 2,Zagorodnoe Sh 2 113152 MOSCOW See on map Total cost No data Shemyakin Institute of Bioorganic Chemistry Russia EU contribution No data Address 16/10,Miklukcho - Maklaya street 117871 Moskva See on map Total cost No data