Objective Degenerative disorders of the nervous system including Alzheimer's, Parkinson's, Huntington's, motor neuron and prion diseases are among the most debilitating illnesses, putting an enormous strain on both social and health care budgets in Europe. As these diseases progress, all but the most primitive functions of the nervous system are lost due to the degeneration and subsequent death of nerve cells. Eventually patients die in a state of incapacitation. Only a small fraction of cases can be accounted for by gene mutations. Altogether, the underlying aetiologies are poorly understood. A hallmark common to these neurodegenerative disorders is the deposition of abnormal protein aggregates. There is currently no treatment available that can halt or prevent, let alone reverse nerve cell degeneration. The APOPIS project is designed to apply the unique information provided by sequencing of the human genome to further the understanding of and to develop treatments for these deva¬ stating diseases. By integrating Europe's leading research centres in clinical research, human genetics, cell biology, genomics, proteomics and bioinformatics, the VERUM Foundation has devised a consortium to identify genes involved, determine their biological functions, establish their role in the patho-physiological processes and identify novel avenues for early diagnosis, treatment and prevention. The chosen approach is based on human population genetics complemented by the identification of modifier genes in model organisms that express both wildtype and mutant variants of known disease-related genes. The consortium meets the prerequisites for such a project: ground breaking research in functional genomics related to human health, creating synergies with and between national research efforts, teaming up with both small biotechnology and pharmaceutical companies for the development of diagnostic tools and new drugs, and providing training and mobility to improve the skills of... Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologydementiaalzheimermedical and health sciencesbasic medicineneurologyparkinsonmedical and health sciencesbasic medicinemedical geneticsmedical and health sciencesbasic medicineneurologyamyotrophic lateral sclerosis Keywords early diagnosis genetics neurodegenerative disorder pathophysiology protein aggregation therapy Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2002-2.1.3-3 - Role and mechanisms of protein aggregation in neurodegenerative diseases Call for proposal FP6-2002-LIFESCIHEALTH See other projects for this call Funding Scheme IP - Integrated Project Coordinator VERUM - FOUNDATION FOR BEHAVIOUR AND ENVIRONMENT EU contribution No data Address Pettenkoferstr. 33 MUENCHEN Germany See on map Total cost No data Participants (33) Sort alphabetically Sort by EU Contribution Expand all Collapse all FLANDERS INTERUNIVERSITY INSTITUTE FOR BIOTECHNOLOGY VZW Belgium EU contribution No data Address Rijvisschestraat 120 ZWIJNAARDE See on map Total cost No data UNIVERSITAET ZUERICH Switzerland EU contribution No data Address Raemistrasse 71 ZURICH See on map Total cost No data UNIVERSITAET BASEL Switzerland EU contribution No data Address Petersplatz 1 BASEL See on map Total cost No data ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland EU contribution No data Address Ecublens LAUSANNE See on map Total cost No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution No data Address Raemistrasse 101 ZURICH See on map Total cost No data ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Germany EU contribution No data Address Fahnenbergplatz FREIBURG See on map Total cost No data LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany EU contribution No data Address Geschwister-Scholl-Platz 1 MUENCHEN See on map Total cost No data MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. Germany EU contribution No data Address Hofgartenstrasse 8 101062 MUENCHEN See on map Total cost No data TECHNISCHE UNIVERSITAET DARMSTADT Germany EU contribution No data Address Karolinenplatz 5 DARMSTADT See on map Total cost No data BAYERISCHE JULIUS-MAXIMILIANS UNIVERSITY OF WUERZBURG Germany EU contribution No data Address Sanderring 2 WUERZBURG See on map Total cost No data MAX DELBRUCK CENTER FOR MOLECULAR MEDICINE Germany EU contribution No data Address Robert-Roessle-Strasse 10 BERLIN See on map Total cost No data PARC CIENTIFIC DE BARCELONA Spain EU contribution No data Address Baldiri i Reixac, 10-12 BARCELONA See on map Total cost No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution No data Address Meyerhofstrasse 1 HEIDELBERG See on map Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution No data Address 101 Rue de Tolbiac PARIS See on map Total cost No data UNIVERSITE DE LILLE II France EU contribution No data Address Rue Paul Duez 42 LILLE See on map Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE France EU contribution No data Address Rue Michel Ange 3 287 PARIS See on map Total cost No data NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS Greece EU contribution No data Address Christou Lada Street 6 ATHENS See on map Total cost No data THE HEBREW UNIVERSITY OF JERUSALEM - THE AUTHORYTY FOR RD Israel EU contribution No data Address Givat Ram Campus, Edmond Safra JERUSALEM See on map Total cost No data FONDAZIONE CAVALIERI OTTOLENGHI Italy EU contribution No data Address Via Verdi 8 TORINO (TURIN) See on map Total cost No data UNIVERSITA VITA-SALUTE SAN RAFFAELE Italy EU contribution No data Address Via Olgettina 58 MILANO See on map Total cost No data CEINGE BIOTECNOLOGIE AVANZATE SCARL Italy EU contribution No data Address Via S.Pansini, 5 NAPLES See on map Total cost No data UNIVERSITA DEGLI STUDI DI GENOVA Italy EU contribution No data Address Via Balbi 5 GENOVA See on map Total cost No data INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY Poland EU contribution No data Address ks. Trojdena 4 WARSZAWA See on map Total cost No data UNIVERSIDADE DE AVEIRO Portugal EU contribution No data Address Campo Universitario AVEIRO See on map Total cost No data UPPSALA UNIVERSITET Sweden EU contribution No data Address St Olofsgatan, 10B 256 UPPSALA See on map Total cost No data LUNDS UNIVERSITET Sweden EU contribution No data Address Paradisgatan 5c 117 LUND See on map Total cost No data UNIVERSITY COLLEGE LONDON United Kingdom EU contribution No data Address Gower Street LONDON See on map Total cost No data UNIVERSITY OF KENT United Kingdom EU contribution No data Address The University of Kent at Canterbury CANTERBURY See on map Total cost No data KING'S COLLEGE LONDON United Kingdom EU contribution No data Address Strand LONDON See on map Total cost No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution No data Address The Old Schools, Trinity Lane CAMBRIDGE See on map Total cost No data EVOTEC NEUROSCIENCES GMBH Germany EU contribution No data Address Schnackenburgallee 114 HAMBURG See on map Total cost No data CELLZOME AG Germany EU contribution No data Address Meyerhofstrasse 1 HEIDELBERG See on map Total cost No data PHILIPPS UNIVERSITY MARBURG Germany EU contribution No data Address Biegenstrasse 12 MARBURG See on map Total cost No data