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PARVOVIRUS BASED LINEAR ANIMAL VECTORS FOR PRODUCTION OF VACCINES AND OTHER USEFUL PROTEINS

Exploitable results

Modification of the genomes of parvoviruses H-1 and MVM, attempting to make them suitable linear vectors, has resulted in: production of recombinant parvoviruses showing transduction specificity for oncogene-transformed cells and having potential for cancer gene therapy; programmed cell killing by means of inducible clones of parvoviral genes encoding nonstructural proteins; demonstration and unravelling of the oncolytic activity of parvoviruses, raising prospects of anticancer applications.

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