Project description
Uncovering the role of neutrophils in neurodegeneration
Neutrophils are primarily responsible for combating infections and mediating inflammatory responses. To capture and kill microorganisms, neutrophils release web-like structures that consist of DNA and antimicrobial proteins called neutrophil extracellular traps (NETs). This same mechanism can also contribute to the development and progression of inflammatory diseases. However, the involvement of NETs in neurodegenerative disorders remains largely unexplored. With the support of the Marie Skłodowska-Curie Actions programme, the TNT project will investigate how NETs contribute to neurodegenerative conditions characterised by abnormal Tau protein accumulation in the brain. Researchers will use animal models and post-mortem human brain tissue to reveal new mechanisms of neuroinflammation and uncover potential therapeutic strategies targeting neutrophil-driven processes.
Objective
Tauopathies, including Alzheimer’s Disease (AD), characterized by the brain accumulation of abnormal Tau proteins, represent a significant unmet medical need. Neuroinflammation is a hallmark of these diseases. Although several neuroimmune regulations, notably involving microglia, have been largely studied recently, the role of neutrophils and the release of neutrophil extracellular traps (NETs) has been overlooked. The TNT project will fill the gap as aimed to (1) characterize the temporal dynamics of neutrophil and NETs involvement vs. Tauopathy progression and (2) evaluate the functional impact of NETs and type I interferon (IFN-I) on disease pathogenesis. Using a combination of approaches, including Tauopathy and Tau seeding models together with post-mortem tissue of patients with primary Tauopathy, the TNT project will advance our understanding of the complex interplay between NETs, glial and Tau pathology, potentially leading to novel therapeutic strategies. The project will study the influence of the biological sex on these mechanisms and assess their therapeutic potential.
The host institute provides a robust platform for bidirectional knowledge exchange, with expertise in Tau transgenic and seeding models, 3D glial cell reconstitution, and inflammasome-Tau pathology, significantly enhancing our research on glial cell changes. My expertise in neuroimmunology and neutrophil biology, will be instrumental in advancing ongoing projects at the host lab. The planned training will enhance my research skills while fostering independence, mentorship, and communication abilities, preparing me for leadership. Engaging in mentorship activities and workshops will equip me with skills to guide and inspire junior researchers, and enhance my ability to communicate complex concepts to diverse audiences. This development will position me as a young leader in neurodegenerative diseases, ready to make significant contributions to scientific advancement and knowledge transfer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pathology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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59000 Lille
France
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