Project description
Breast cancer treatment with cutting-edge technology
Breast cancer continues to be a leading cause of death among women globally, with the disease’s complex, ever-changing nature posing significant challenges. A key factor in its progression is the tumour microenvironment (TME), particularly the inflammatory components such as cytokines. While targeted therapies have improved outcomes for some, treating aggressive subtypes like triple-negative breast cancer (TNBC) remains a struggle. Supported by the Marie Skłodowska-Curie Actions programme, the CoSMOS-BC project is developing a microfluidic co-culture system that provides real-time cytokine detection within the TME. This advanced technology aims to simulate human biology more effectively, accelerating drug development, reducing animal testing, and paving the way for personalised, more effective breast cancer therapies.
Objective
Breast cancer (BC) remains one of the leading causes of cancer-related deaths among women worldwide, with incidence rates rising and a significant economic burden. The disease is characterized by its dynamic and heterogeneous nature, involving complex molecular, genetic, and cellular changes.
The tumor microenvironment (TME), particularly its inflammatory components such as cytokines, plays a crucial role in BC progression and treatment response. While targeted therapies have improved outcomes for some BC subtypes, significant challenges persist especially in treating triple-negative breast cancer (TNBC), which lacks specific molecular targets. The development of microfluidics devices that enable precise spatiotemporal control in cell culture offers new opportunities to simulate and study the TME more effectively than conventional methods. Such devices are crucial for modeling cancer progression and deepening our understanding of its biology. By mimicking human physiology, they provide a controlled platform for testing new therapies, reducing animal testing, and accelerating drug development. Additionally, they facilitate personalized medicine by recreating patient-specific tumor microenvironments and supporting tailored treatments. These advancements also bridge the gap between in vitro studies and clinical applications, driving oncology research forward and offering hope to millions of people. Aiming this, CoSMOS-BC proposes a microfluidic co-culture system with integrated sensors for real-time cytokine detection at the cellular level, designed to provide insights into intercellular communication and understand cellular dynamics within the TME. CoSMOS-BC has the potential to make significant strides in both the diagnosis and personalized treatment of breast cancer, paving the way for more effective and targeted therapeutic strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
48940 LEIOA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.