Objective Lung transplantation (LT) is the standard of care for selected patients with chronic respiratory failure. Chronic lung allograft dysfunction (CLAD) (i.e. “Bronchiolitis obliterans syndrome” (BOS) and “Restrictive Allograft Syndrome” (RAS)) represents a major health risk for LT recipients, requiring the use of heavy treatments and possible retransplantation. Observed in almost 50% of patients after 5 years post LT, it is currently impossible to predict the appearance of CLAD before the onset of first symptoms. This project aims to develop the SysCLAD model which will allow to predict, within the 1st year post LT, the recipients at risk of developing CLAD by 3 years post LT. Building upon available data from the cohort of lung transplantation (COLT, recruited since mid-2009), this project will integrate new LT recipients to form the European cohort of lung transplantation (ECOLT). The SysCLAD prediction tool will be based on a mathematical model developed through a system biology approach integrating both clinical and biological data collected from a total of 400 LT recipients. The model will be validated on the first 200 LT recipients (3 years follow-up at project start) and refined using the new set of 200 LT data with 3 years follow-up by 2014. The aim is to identify and validate the signature of CLAD both at the clinical and molecular levels to allow for an early recognition and specific interventions in patients at risk of CLAD. The implementation of the model is expected to significantly improve the cost-effectiveness of post-LT treatments, limit the risk of graft rejection in LT recipients and, ultimately lead to an improved quality of life and a prolonged life expectancy of patients following LT. Finally, the SysCLAD model holds further great promises in the context of other chronic bronchial inflammatory diseases of major incidence such as severe asthma and Chronic Obstructive Pulmonary Disease (COPD) to predict decline in lung function. Fields of science medical and health sciencesclinical medicinepneumologyasthmamedical and health scienceshealth sciencesinflammatory diseasesmedical and health sciencesclinical medicinetransplantationnatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2012.2.1.2-1 - Systems medicine: SME-driven research applying systems biology approaches to address medical and clinical needs Call for proposal FP7-HEALTH-2012-INNOVATION-1 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS EU contribution € 454 400,50 Address RUE DU BUGNON 21 1011 Lausanne Switzerland See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Thuy Oetli (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE JOSEPH FOURIER GRENOBLE 1 France EU contribution € 522 200,00 Address Avenue Centrale, Domaine Universitaire 621 38041 GRENOBLE See on map Activity type Higher or Secondary Education Establishments Administrative Contact Yann Leroux (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES France EU contribution € 848 700,00 Address Allee de l'Ile Gloriette 5 44093 Nantes See on map Region Pays de la Loire Pays de la Loire Loire-Atlantique Activity type Higher or Secondary Education Establishments Administrative Contact Karine Botturi-Cavaillès (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NOVADISCOVERY France EU contribution € 346 970,00 Address 1 PLACE GIOVANNI DA VERRAZZANO 69009 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact François-Henri Boissel (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOMAX INFORMATICS AG Germany EU contribution € 243 765,75 Address ROBERT KOCH STRASSE 2 82152 STEINKIRCHEN See on map Region Bayern Oberbayern München, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Dieter Maier (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROFINS GENOMICS EUROPE PHARMA AND DIAGNOSTICS PRODUCTS & SERVICES SANGER PCR GMBH Germany EU contribution € 416 616,00 Address JAKOB STADLER PLATZ 7 78467 Konstanz See on map Region Baden-Württemberg Freiburg Konstanz Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Janet Kenklies (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FINOVATIS France EU contribution € 101 000,00 Address 62 RUE DE BONNEL 69003 Lyon See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Rhône Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact David Koubi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data University of Zurich Switzerland EU contribution € 37 500,00 Address RAMISTRASSE 71 8006 ZURICH See on map Activity type Higher or Secondary Education Establishments Administrative Contact Andreas Ledergerber (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HLA ET MEDECINE France EU contribution € 27 999,75 Address Avenue Claude Vellefaux 1 75010 Paris See on map Activity type Research Organisations Administrative Contact Charles Auffray (Dr.) Links Contact the organisation Opens in new window Total cost No data