Objective Validated alternative test methods are urgently required for safety toxicology of drugs, chemicals and cosmetics. Both REACH and 7th amendment of Cosmetics Directive call for the broad replacement of animal experiments on a short-term. While some animal tests for topical toxicity have been successfully replaced one by one by alternative methods, systemic toxicities require new test strategies in order to achive an adequate safety level. The aim of A-Cute-Tox is to develop a simple and robust in vitro t esting strategy for prediction of human acute systemic toxicity, which could replace the animal acute toxicity tests used today. The involvement of ECVAM in the project management and that of regulators (such as ECB) guarantees of the follow-up. The Scie ntific objectives of the project are: 1. Compilation, critical evaluation and generation of high quality in vitro and in vivo data for comparative analysis. 2. Identifying factors (ADE, metabolism and organ specificity) that influence the correlation betwe en in vitro toxicity (concentration) and in vivo toxicity (dosage), and to define an algorithm that accounts for this. 3. Explore innovative tools and cellular systems to identify new end-points and strategies to better anticipate animal and human toxicit y. 4. To design a simple, robost and reliable in vitro test strategy amenable for robotic testing, associated with the prediction model for acute toxicity. The project will develop the concepts required to compose testing strategies via the continuous imp lementation of novel in vitro and in silico alternatives. The approach requires the dimensions of a transnational Integrated Project, involving prominent toxicity research groups in the EU, close monitoring by and input from the regulatory community and p rofessional managerial steering. In return, it offers the realistic opportunity to achive a substantial reduction of animal experiments in acute systemic toxicity assessments. Fields of science medical and health sciencesbasic medicinetoxicology Keywords Acute toxicity testing BBB models QSAR biokinetic modelling biotransformation distribution gut absorption hepatotoxicity human in silico models in vitro models nephrotoxicity neurotoxicity Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2003-1.2.3-1 - Optimisation of test batteries for human acute toxicity Call for proposal FP6-2003-LIFESCIHEALTH-I See other projects for this call Funding Scheme NoE - Network of Excellence Coordinator UNIVERSITY OF OULU EU contribution No data Address PENTTI KAITERAN KATU 1 8000 OULU Finland See on map Links Website Opens in new window Total cost No data Participants (35) Sort alphabetically Sort by EU Contribution Expand all Collapse all EXPERTRÅDET ECB MILJÖKOMPETENS AB Sweden EU contribution No data Address Rådan 3 SOLLENTUNA See on map Links Website Opens in new window Total cost No data FUNDACIÓN HOSPITAL UNIVERSITARIO LA FE Spain EU contribution No data Address AVDA CAMPANAR 21 VALENCIA See on map Links Website Opens in new window Total cost No data JOINT RESEARCH CENTRE (EUROPEAN COMMISSION DG JRC) Belgium EU contribution No data Address RUE DE LA LOI BRUXELLES See on map Links Website Opens in new window Total cost No data NEUROPHARMA S.A. Spain EU contribution No data Address CALLE JOSÉ ABASCAL, 2 MADRID See on map Links Website Opens in new window Total cost No data UTRECHT UNIVERSITY Netherlands EU contribution No data Address HEIDELBERGLAAN 8 80125 UTRECHT See on map Links Website Opens in new window Total cost No data BIOVITRUM AB Sweden EU contribution No data Address LINDHAGENSGATAN 133 STOCKHOLM See on map Links Website Opens in new window Total cost No data THE UNIVERSITY OF NOTTINGHAM United Kingdom EU contribution No data Address UNIVERSITY PARK NOTTINGHAM See on map Links Website Opens in new window Total cost No data UNIVERSITAT DE VALENCIA. ESTUDI GENERAL (THE UNIVERSITY OF VALENCIA) Spain EU contribution No data Address AVDA.BIASCO IBANEZ 13 VALENCIA See on map Links Website Opens in new window Total cost No data COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution No data Address 25 rue Leblanc PARIS See on map Links Website Opens in new window Total cost No data CENTRO DE INVESTIGACIONES ENERGETICAS, MEDIOAMBIENTALES Y TECNOLOGICAS Spain EU contribution No data Address AVENIDA COMPLUTENSE, N°22 MADRID See on map Links Website Opens in new window Total cost No data UNIVERSITÉ CATHOLIQUE DE LOUVAIN Belgium EU contribution No data Address PLACE DE L'UNIVERSITÉ, 1 LOUVAIN-LA-NEUVE See on map Links Website Opens in new window Total cost No data CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution No data Address Serrano 117 MADRID See on map Links Website Opens in new window Total cost No data SCIENTIFIC INSTITUTE OF PUBLIC HEALTH Belgium EU contribution No data Address WYTSMANSTRAAT 14 BRUSSEL See on map Links Website Opens in new window Total cost No data ADVANCELL ADVANCED IN VITRO CELL TECHNOLOGIES, S.A. Spain EU contribution No data Address C/BALDIRI / REIXAC 10 BARCELONA See on map Links Website Opens in new window Total cost No data STOCKHOLMS UNIVERSITET Sweden EU contribution No data Address UNIVERSITETSVÄGEN 10 STOCKHOLM See on map Links Website Opens in new window Total cost No data BAYER HEALTH CARE Germany EU contribution No data Address APRATHER WEG 18 WUPPERTAL See on map Links Website Opens in new window Total cost No data THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN United Kingdom EU contribution No data Address Kings College ABERDEEN See on map Links Website Opens in new window Total cost No data MEDICAL UNIVERSITY OF WARSAW Poland EU contribution No data Address Zwirki i Wigury 61 WARSAW See on map Links Website Opens in new window Total cost No data UNIVERSITÉ DE LAUSANNE Switzerland EU contribution No data Address BÂTIMENT DU RECTORAT ET DE L' ADMINISTRATION (BRA) LAUSANNE See on map Links Website Opens in new window Total cost No data VRIJE UNIVERSITEIT BRUSSEL Belgium EU contribution No data Address PLEINLAAN 2 BRUSSELS See on map Links Website Opens in new window Total cost No data FUNDACIÓN GAIKER Spain EU contribution No data Address PARQUE TECNOLÓGICO DE ZAMUDIO, EDIFICIO 202 ZAMUDIO (BIZKAIA) See on map Links Website Opens in new window Total cost No data KUNGLIGA TEKNISKA HÖGSKOLAN Sweden EU contribution No data Address VALHALLAVÄGEN 79 STOCKHOLM See on map Links Website Opens in new window Total cost No data NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland EU contribution No data Address BELFIELD DUBLIN 4 See on map Links Website Opens in new window Total cost No data UMEÅ UNIVERSITY Sweden EU contribution No data Address UMEÅ UNIVERSITY UMEÅ See on map Links Website Opens in new window Total cost No data ISTITUTO SUPERIORE DI SANITA ' Italy EU contribution No data Address VIALE REGINA ELENA 299 ROMA See on map Links Website Opens in new window Total cost No data UNIVERSITÄT ZÜRICH Switzerland EU contribution No data Address RAEMISTRASSE 71 ZURICH See on map Links Website Opens in new window Total cost No data FRAUNHOFER GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V Germany EU contribution No data Address HANSASTRASSE 27 C MÜNCHEN See on map Links Website Opens in new window Total cost No data PALACKY UNIVERSITY, OLOMOUC Czechia EU contribution No data Address KRIZKOVSKEHO 8 OLOMOUC See on map Links Website Opens in new window Total cost No data IN VITRO TESTING INDUSTRIAL PLATFORM Netherlands EU contribution No data Address 9143 ROTTERDAM See on map Total cost No data UNIVERSITY OF KONSTANZ, CENTRE FOR HEALTH AND CONSUMER PROTECTION Germany EU contribution No data Address UNIVERSITAETSSTR. 10 M 655 KONSTANZ See on map Links Website Opens in new window Total cost No data UPPSALA UNIVERSITY Sweden EU contribution No data Address SANKT OLOFSGATAN 10 B 256 UPPSALA See on map Links Website Opens in new window Total cost No data UNIVERSITE D'ARTOIS France EU contribution No data Address FACULTE DES SCIENCES - RUE JEAN SOUVRAS SP18 LENS See on map Links Website Opens in new window Total cost No data SWEDISH FUND FOR RESEARCH WITHOUT ANIMAL EXPERIMENTS Sweden EU contribution No data Address GAMLA HUDDINGEVÄGEN 437 ÄLVSJÖ See on map Links Website Opens in new window Total cost No data UNIVERSITAT DE BARCELONA Spain EU contribution No data Address GRAN VIA DE LES CORTS CATALANES 585 (VICERECTORAT DE RECERCA; OPER) BARCELONA See on map Links Website Opens in new window Total cost No data FUTURE PARTICIPANT 1 Afghanistan EU contribution No data Address See on map Total cost No data