Objective Malaria is a major public health problem in the developing world and is endemic in many regions of India. The development of novel strategies for malaria control requires a better understanding of the biology of malaria parasites. Our project aims at bringing a significant contribution to this field, through dissecting the signalling pathways that regulate essential processes in the life cycle of malaria parasites. The proposed research will merge two lines of investigation that have thus far been conducted largely independently from each other, namely: (i) the characterisation of components of signal transduction pathways (protein kinases, nucleotide cyclases, calcium signalling mediators) in malaria parasites; (ii) the study of specific biological processes during the life cycle of malaria parasites. Merging these two fields of malaria research will ensure a high level of complementarity and synergy within the consortium. Specific workpackages will be centred on understanding signalling-dependent regulation in the following processes and stage transition within the life cycle of malaria parasites: • erythrocyte infection (invasion, parasite proliferation) • sexual development (gametocytogenesis, gametogenesis, transmission to the mosquito vector) • hepatocyte infection (invasion, parasite proliferation, egress) • membrane dynamics (trafficking, transporters) Approaches will include proteomics, reverse genetics, structural biology, and the use of animal models of malaria. The consortium is constituted of EU and Indian partners with a proven track record either in research into one of the developmental stages/processes described above, or in signal transduction in malaria parasites. The project will significantly strenghten EU-India cooperation in this highly relevant topic. Fields of science medical and health scienceshealth sciencesinfectious diseasesmalariamedical and health scienceshealth sciencespublic healthnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencesbiological sciencesmolecular biologystructural biologynatural sciencesbiological scienceszoologyinvertebrate zoology Keywords Malaria differentiation erythrocyte hepatocyte invasion phosphorylation proliferation schizogony signalling sporogony Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH-2007-2.3.2-12 - Highly innovative research in HIV/AIDS, malaria and tuberculosis between Indian and European partners Call for proposal FP7-HEALTH-2007-B See other projects for this call Funding Scheme CP-SICA - Collaborative project for specific cooperation actions dedicated to international cooperation partner countries (SICA) Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE EU contribution € 472 000,00 Address RUE DE TOLBIAC 101 75654 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Rofigua Hakem (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (16) Sort alphabetically Sort by EU Contribution Expand all Collapse all ISTITUTO SUPERIORE DI SANITA Italy EU contribution € 166 000,00 Address Viale Regina Elena 299 00161 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Rosa Maria Martoccia (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDICAL RESEARCH COUNCIL United Kingdom EU contribution € 332 000,00 Address 20 Park Crescent W1B 1AL LONDON See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Michele Marron (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Germany EU contribution € 166 000,00 Address BERNHARD NOCHT STRASSE 74 20359 Hamburg See on map Region Hamburg Hamburg Hamburg Activity type Research Organisations Administrative Contact Volker Theo Heussler (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER United Kingdom EU contribution € 166 000,00 Address KEPPEL STREET WC1E 7HT London See on map Region London Inner London — West Camden and City of London Activity type Higher or Secondary Education Establishments Administrative Contact Penny Ireland (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GENOME RESEARCH LIMITED United Kingdom EU contribution € 166 000,00 Address WELLCOME SANGER INSTITUTE WELLCOME GENOME CAMPUS HINXTON CB10 1SA SAFFRON WALDEN See on map Region East of England East Anglia Cambridgeshire CC Activity type Research Organisations Administrative Contact Elisabeth Muller (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ST GEORGE'S HOSPITAL MEDICAL SCHOOL United Kingdom EU contribution € 166 000,00 Address CRANMER TERRACE SW17 0RE London See on map Region London Inner London — West Wandsworth Activity type Higher or Secondary Education Establishments Administrative Contact Susan Mcpheat (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER Netherlands EU contribution € 166 000,00 Address LANGE KLEIWEG 161 2288 GJ Rijswijk Zh See on map Region West-Nederland Zuid-Holland Agglomeratie ’s-Gravenhage Activity type Research Organisations Administrative Contact Willem Slingerland (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITATSKLINIKUM HEIDELBERG Participation ended Germany EU contribution No data Address IM NEUENHEIMER FELD 672 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Thorsten Brietz (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT PASTEUR France EU contribution € 86 000,00 Address RUE DU DOCTEUR ROUX 25-28 75724 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nadia Khelef (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG Germany EU contribution € 166 000,00 Address SANDERRING 2 97070 Wuerzburg See on map Region Bayern Unterfranken Würzburg, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Christian Gloggengiesser Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF GLASGOW United Kingdom EU contribution € 332 000,00 Address UNIVERSITY AVENUE G12 8QQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Administrative Contact Joe Galloway (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data STICHTING RADBOUD UNIVERSITEIT Netherlands EU contribution € 166 000,00 Address HOUTLAAN 4 6525 XZ Nijmegen See on map Region Oost-Nederland Gelderland Arnhem/Nijmegen Activity type Higher or Secondary Education Establishments Administrative Contact Peter Van Woensel (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY Italy EU contribution € 180 000,00 Address PADRICIANO 99 34149 Trieste See on map Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Research Organisations Administrative Contact Chetan Chitnis (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data JAWAHARLAL NEHRU UNIVERSITY India EU contribution € 90 000,00 Address NEW MEHRAULI ROAD 110 067 New Delhi See on map Activity type Higher or Secondary Education Establishments Administrative Contact Suman Dhar (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data NATIONAL INSTITUTE OF IMMUNOLOGY SOCIETY India EU contribution € 90 000,00 Address ARUNA ASAF ALI MARG 110067 New Delhi See on map Activity type Research Organisations Administrative Contact Avadhesha Surolia (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INDIAN INSTITUTE OF SCIENCE India EU contribution € 90 000,00 Address CROSS MALLESHWARAM 18 560012 Bangalore See on map Activity type Higher or Secondary Education Establishments Administrative Contact Utpal Tatu (Prof.) Links Contact the organisation Opens in new window Total cost No data
