Objective Future breakthroughs in the understanding of fundamental biological processes causing major diseases are expected from the development of miniaturized probes or microscopes able to detect and identify a single or a small number of molecules. The SingleMoleculeDetection (SMD) proposal will develop a unique device able to perform simultaneously and in a dynamic way force and spectroscopic measurements. We will design and fabricate novel devices for the generation of plasmon polaritons as well as combine photonic crystals and plasmonic nanolenses. These new devices will be able to detect few/single molecules through Raman, InfraRed and Terahertz (THz) signals and in combination with Atomic Force Microscopy and Optical Tweezer force spectroscopy with a spatial resolution in the sub-10 nm for Raman and IR and sub-100 nm for the THz region. The complete characterization of single unknown molecule will be demonstrated through: i- investigations on the chemical and physical properties of membrane receptors, such as rhodopsin, odorant receptors and ionic channels; ii- identification of new molecules involved in cancer development and metastasis. The new devices will allow the acquisition of THz images and we will explore the possibilities of this new spectral region for biomedical scanning. The SMD proposal is based on an original idea of the coordinator, prof. E. di Fabrizio and will be exploited thanks to the complementary expertise present in the different sites and to a tight coordination between the various groups. The design, fabrication and testing will be performed at UMG, TASC and CBM Integration in a single instrument will be carried out at TASC, CBM, IIT Nanotec, RUB. Validation activities will be performed by all the partners taking advantage of the world leading expertise of the TUDO and the STRATH- AC in spectroscopy of natural and artificial biological systems. The SME NANOTEC and CBM will provide the commercial exploitation of the obtained results. Fields of science natural sciencesphysical sciencesopticsmicroscopymedical and health sciencesclinical medicineoncologynatural sciencesphysical sciencesopticsspectroscopy Keywords Atomic Force Microscope Molecule Manipulation Optical Tweezer Photonic Crystal Plasmonics Raman Spectroscopy Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP-2008-1.1-1 - Converging sciences and technologies (nano, bio, info and/or cogni) Call for proposal FP7-NMP-2008-SMALL-2 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator CONSORZIO PER IL CENTRO DI BIOMEDICINA MOLECOLARE SCARL EU contribution € 896 136,40 Address STRADA STATALE 14 KM 163 5 BASOVIZZA 34149 Trieste Italy See on map Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Research Organisations Administrative Contact Anna Lucia Bellina (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITA DEGLI STUDI MAGNA GRAECIA DI CATANZARO Italy EU contribution € 271 466,00 Address VIALE EUROPA LOCALITA GERMANETO 88100 Catanzaro See on map Region Sud Calabria Catanzaro Activity type Higher or Secondary Education Establishments Administrative Contact Roberto Sigilli (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data RUHR-UNIVERSITAET BOCHUM Germany EU contribution € 475 978,00 Address UNIVERSITAETSSTRASSE 150 44801 Bochum See on map Region Nordrhein-Westfalen Arnsberg Bochum, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Martina Havenith (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data TECHNISCHE UNIVERSITAT DORTMUND Germany EU contribution € 429 850,00 Address AUGUST SCHMIDT STRASSE 4 44227 Dortmund See on map Region Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Daniel Schneider (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF STRATHCLYDE United Kingdom EU contribution € 499 232,00 Address Richmond Street 16 G1 1XQ Glasgow See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Administrative Contact Martin Gregory (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CONSIGLIO NAZIONALE DELLE RICERCHE Italy EU contribution € 267 448,00 Address PIAZZALE ALDO MORO 7 00185 Roma See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Martina Centazzo (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Nanotec Electronica SL Spain EU contribution € 315 500,00 Address RONDA DE PONIENTE 12 2 C 28760 TRES CANTOS MADRID See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Leonor Badorrey (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Italy EU contribution € 265 889,60 Address VIA MOREGO 30 16163 Genova See on map Region Nord-Ovest Liguria Genova Activity type Research Organisations Administrative Contact Gabriele Ballero (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
