Objective Recent evidence shows that a large share of proteins gain functional advantages by remaining natively unstructured, either completely or partially, thus challenging well-established concepts in structural biology. In order to characterize the highly dynamical nature of such “intrinsically disordered proteins”, and follow their (possible) reorganization by interacting with partners, new integrated multidisciplinary approaches combining a variety of experimental and computational techniques are needed. Our proposal is focused on NMR spectroscopy, since this technique offers an arsenal of effective tools for the study of the structural and dynamical properties of disordered states of proteins at atomic resolution in systems as complex as whole cells. In order to achieve the full potential of this approach, however, current methods should be further developed and properly interfaced with other complementary techniques. The purpose of our network is thus to establish a framework to train a new generation of young researchers and help them develop the necessary skills to successfully respond to the challenges associated with the elucidation of the functional role of intrinsically disordered protein states. If achieved, this goal will provide us with a more quantitative understanding of the biochemical processes at the basis of life and have a significant impact in biomedical research and in the design of new drugs. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopynatural sciencesbiological sciencesmolecular biologystructural biology Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2010-ITN - Marie-Curie Action: "Initial Training Networks" Call for proposal FP7-PEOPLE-2010-ITN See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE EU contribution € 580 132,93 Address PIAZZA DI SAN MARCO 4 50121 FIRENZE Italy See on map Region Centro (IT) Toscana Firenze Activity type Higher or Secondary Education Establishments Administrative Contact Isabella Caterina Felli (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution € 529 875,92 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Jean-Xavier Boucherle (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany EU contribution € 477 452,04 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Phil Irving (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data VIB VZW Belgium EU contribution € 469 476,33 Address SUZANNE TASSIERSTRAAT 1 9052 ZWIJNAARDE - GENT See on map Region Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent Activity type Research Organisations Administrative Contact Rik Audenaert (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 561 771,18 Address TRINITY LANE THE OLD SCHOOLS CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Keith Cann (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data BIOTALENTUM TUDASFEJLESZTO KFT Hungary EU contribution € 331 464,31 Address AULICH LAJOS UTCA 26 2100 Goedoello See on map Region Közép-Magyarország Pest Pest Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andras Dinnyes (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GIOTTO BIOTECH SRL Italy EU contribution € 258 621,83 Address VIA FRANCESCO CRISPI 6 50129 FIRENZE See on map Region Centro (IT) Toscana Firenze Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Simona Fedi (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Bruker Biospin AG Switzerland EU contribution € 223 037,41 Address Industriestrasse 26 8117 Faellanden See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rainer Kuemmerle (Dr.) Links Contact the organisation Opens in new window Total cost No data MAGYAR TUDOMANYOS AKADEMIA SZEGEDI BIOLOGIAI KOZPONT ENZIMOLOGIAI INTEZET Participation ended Hungary EU contribution No data Address Karolina ut 29-31 1113 BUDAPEST See on map Activity type Higher or Secondary Education Establishments Administrative Contact Peter Tompa (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data PROTERA SRL Participation ended Italy EU contribution No data Address Viale delle Idee 22 50019 Sesto Fiorentino (FI) See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mario Lorenzoni (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
