Obiettivo Despite the advent of the antibiotic era, infectious diseases retain their pre-eminent position as major worldwide causes of morbidity and mortality. This problem has been worsen by the emergence of multi-antibiotic resistant bacteria and the failure of Pharmaceutical company drug discovery programmes to design antibiotics with truly novel modes of action. NABATIVI has put together a unique consortium made of six academic insitutions and three highly recognized SMEs with complementary expertise in the fields of molecular pathogenicity and broad expertise in drug discovery, optimisation, preclinical development. The consortium has been specifically designed to generate new strategies leading to the identification and validation of novel targets for antimicrobials using as model organisms the gram-negatives Pseudomonas aeruginosa and Burkholderia cenocepacia as they are key agents of morbidity and mortality worldwide in a wide range of diseases. The versatility of these model bacteria will enable the results obtained to be extrapolated to other bacterial pathogens. The extensive involvement of SMEs in this consortium will enable the selection of lead compounds against the identified targets from their large libraries of natural and synthetic chemicals which after validation will establish the basis for the development of new classes of antibacterial drugs. This will result in a reduction in the incidence and improvement of the treatment of infections caused by these organisms with a direct impact on the quality of life and the life expectancy of the affected risk patient populations. Campo scientifico medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverysocial sciencessociologydemographymortalitynatural sciencesbiological sciencesmicrobiologybacteriologymedical and health scienceshealth sciencesinfectious diseasesmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics Parole chiave Gram negative bacteria antibacterial antimicrobial resistance lead compound novel drug target Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases HEALTH-2007-2.3.1-1 - Novel targets for drugs against Gram negative bacteria Invito a presentare proposte FP7-HEALTH-2007-B Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore UNIVERSITA VITA-SALUTE SAN RAFFAELE Contributo UE € 610 529,00 Indirizzo VIA OLGETTINA 58 20132 Milano Italia Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Maria Rosa Pedrazzi (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (9) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto THE UNIVERSITY OF NOTTINGHAM Regno Unito Contributo UE € 681 600,00 Indirizzo University Park NG7 2RD Nottingham Mostra sulla mappa Regione East Midlands (England) Derbyshire and Nottinghamshire Nottingham Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Paul Cartledge (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato EBERHARD KARLS UNIVERSITAET TUEBINGEN Germania Contributo UE € 618 960,00 Indirizzo GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen Mostra sulla mappa Regione Baden-Württemberg Tübingen Tübingen, Landkreis Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Gerd Döring (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ACTAR AB Svezia Contributo UE € 524 860,00 Indirizzo NOBELS VAEG 3 171 77 STOCKHOLM Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Eva Montgomerie (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato University of Zurich Svizzera Contributo UE € 674 800,00 Indirizzo RAMISTRASSE 71 8006 ZURICH Mostra sulla mappa Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo John Robinson (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI MILANO Italia Contributo UE € 699 600,00 Indirizzo Via Festa Del Perdono 7 20122 Milano Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Stefania Varotto (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato GREENPHARMA S.A. Francia Contributo UE € 527 600,00 Indirizzo Allée du Titane 3 45100 Orléans Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Jean-Yves Berthon (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato KOBENHAVNS UNIVERSITET Danimarca Contributo UE € 522 880,00 Indirizzo NORREGADE 10 1165 Kobenhavn Mostra sulla mappa Regione Danmark Hovedstaden Byen København Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ivan Kristoffersen (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Polyphor AG Svizzera Contributo UE € 341 500,00 Indirizzo Hegenheimermattweg 4123 Allschwil Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Christian Ludin (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FONDAZIONE CENTRO SAN RAFFAELE Italia Contributo UE € 303 671,00 Indirizzo VIA OLGETTINA 60 20132 Milano Mostra sulla mappa Regione Nord-Ovest Lombardia Milano Tipo di attività Research Organisations Contatto amministrativo Maria Rosa Pedrazzi (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato
