Obiettivo The heritability of coronary artery disease (CAD) and myocardial infarction (MI) has been unequivocally demonstrated. However, traditional technology, for example based on investigation of candidate genes, or linkage analysis, has failed to elucidate the genetic roots of the Number One killer in society. Cardiogenics will exploit the major advances in genomics to identify risk genes for CAD/MI. The investigators have established large collections of affected individuals with an exceptionally strong genetic signal and subjected these to high-density genome-wide association analyses. These and other components of a multi-step genome-wide based strategy will uncover strong candidate genes (SCG). The implications of SCGs will be tested by the integrated functional genomics programme. Specifically, we will relate variants of SCG to the transcriptomes of monocytes and coronary plaques as well as more complex human phenotypes. Moreover, SCG variants will be further characterised, by small interfering RNA technology in stem cells, at the protein level, and functionally investigated. Ultimately, our globally competitive, integrated programmes spanning from genome-wide mapping to cell biology will determine the physiological roles of genes and proteins implicated in CAD/MI genetics and thus lead to the identification of novel drugable targets.The likelihood that we will achieve our ambitious goals is greatly increased by the fact that we have brought together leading European academic groups, and received substantial financial and logistic support from major national initiatives (WTCCC in the UK and NGFN in Germany), large pan-European projects (MORGAM, BLOODOMICS, EUMORPHIA), and from Europe's premier genome centre, the WTSI. The seamless transfer of inventions to the small-and-medium-sized enterprises (EUROIMMUN and TRIUM) and the pharmaceutical sector will provide the basis of a return on the initial investment'. Campo scientifico medical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosismedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesmedical biotechnologycells technologiesstem cellsnatural sciencesbiological sciencesgeneticschromosomesnatural sciencesbiological sciencesgeneticsgenomes Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2005-2.1.1-1 - Genome-wide mapping and functional genomics of susceptibility to coronary artery disease Invito a presentare proposte FP6-2005-LIFESCIHEALTH-6 Vedi altri progetti per questo bando Meccanismo di finanziamento IP - Integrated Project Coordinatore UNIVERSITÄT ZU LÜBECK Contributo UE Nessun dato Indirizzo Ratzeburger Allee 160 23538 LUEBECK Germania Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (18) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF LEICESTER Regno Unito Contributo UE Nessun dato Indirizzo University Road LEICESTER Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE Nessun dato Indirizzo Rue de Tolbiac 101 PARIS CEDEX 13 Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Regno Unito Contributo UE Nessun dato Indirizzo The Old Schools, Trinity Lane CAMBRIDGE Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF REGENSBURG Germania Contributo UE Nessun dato Indirizzo Franz-Josef-Strauss-Allee 11 93042 REGENSBURG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato GENOME RESEARCH LIMITED Regno Unito Contributo UE Nessun dato Indirizzo 215 Euston Road LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato SANQUIN BLOOD SUPPLY FOUNDATION Paesi Bassi Contributo UE Nessun dato Indirizzo Plesmanlaan 125 9892 AMSTERDAM Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato GSF-FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT, GMBH Germania Contributo UE Nessun dato Indirizzo Ingolstadter Landstrasse 1 MUENCHEN-NEUHERBERG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato JOHANNES GUTENBERG-UNIVERSITÄT MAINZ Germania Contributo UE Nessun dato Indirizzo Saarstr. 21 MAINZ Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UPPSALA UNIVERSITET Svezia Contributo UE Nessun dato Indirizzo St Olofsgatan 10B 256 UPPSALA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato THE QUEEN'S UNIVERSITY OF BELFAST Regno Unito Contributo UE Nessun dato Indirizzo University Road BELFAST Mostra sulla mappa Costo totale Nessun dato UNIVERSITY OF LEEDS Regno Unito Contributo UE Nessun dato Indirizzo Woodhouse Lane LEEDS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ASSOCIAZIONE PER LO STUDIO DELLA TROMBOSI IN CARDIOLOGIA Italia Contributo UE Nessun dato Indirizzo Piazza Golgi 1 PAVIA Mostra sulla mappa Costo totale Nessun dato EUROIMMUN MEDIZINISCHE LABORDIAGNOSTICA AG Germania Contributo UE Nessun dato Indirizzo Seekamp 31 LUBECK Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato TRIUM ANALYSIS ONLINE GMBH Germania Contributo UE Nessun dato Indirizzo Hohenlindenerstr 1 MUNICH Mostra sulla mappa Costo totale Nessun dato TECHNISCHE UNIVERSITÄT MÜNCHEN Germania Contributo UE Nessun dato Indirizzo Arcisstrasse 21 MÜNCHEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITY HOSPITAL REGENSBURG Germania Contributo UE Nessun dato Indirizzo Franz-Josef-Strauss-Allee 11 93042 REGENSBURG Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato UNIVERSITÄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITÄT MAINZ Germania Contributo UE Nessun dato Indirizzo Langenbeckstr. 1 MAINZ Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato NATIONAL INSTITUTE OF HEALTH AND WELFARE Finlandia Contributo UE Nessun dato Indirizzo Mannerheimintie 166 HELSINKI Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato