Obiettivo This project aims to unite global efforts to target the highly druggable class of enzymes called cyclic nucleotide phosphodiesterases (PDEs) in the fight for neglected parasitic diseases (NPD). It will establish a drug discovery platform, PDE4NPD, that combines phenotypic screening with efficient target-centric drug discovery, including target validation, various strategies for compound screening, PDE hit and lead optimization, safety and toxicology assessments and evaluation of anti-parasitic activity. The platform will make use of the target class expertise that the participating SMEs have gained when developing drugs for human and parasite PDEs, while all public partners offer proven experience in the field of NPD. The SMEs will adopt and progress existing PDE inhibitors that are in different stages of the drug discovery pipeline (i.e. target validation, hit and lead optimization). The current portfolio of inhibitors have clinical potential for treating sleeping sickness, Chagas' disease and leishmaniasis. Finding novel hits and leads for the PDEs that are associated with helminth diseases is also foreseen. The platform is open for targeting other NPD, and a broad panel of phenotypic screens (including malaria) is available to test PDE inhibitors. The phenotypic screening is performed by world-renowned groups, including two institutes in endemic countries. By capturing human and parasite PDE-related data in annotated chemogenomics databases, PDE-4-NPD will achieve the knowledge accumulation that is typical for target-centric approaches, thereby making the NPD drug development more efficient and enabling the SMEs to take advantage of the molecular understanding that is key for developing new medicines. The PDE4NPD platform constitutes an ideal basis for creating fruitful collaborations with both public and private partners word-wide. Campo scientifico medical and health sciencesclinical medicinepsychiatrysleep disordersmedical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health scienceshealth sciencesinfectious diseasesmalarianatural sciencesbiological sciencesgeneticsnucleotidesnatural sciencesmathematicspure mathematicsmathematical analysisdifferential equationspartial differential equations Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2013.2.3.4-2 - Drug development for neglected parasitic diseases Invito a presentare proposte FP7-HEALTH-2013-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore STICHTING VU Contributo UE € 1 215 666,00 Indirizzo DE BOELELAAN 1105 1081 HV Amsterdam Paesi Bassi Mostra sulla mappa Regione West-Nederland Noord-Holland Groot-Amsterdam Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Rob Leurs (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (10) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto UNIVERSITY OF GLASGOW Regno Unito Contributo UE € 786 759,00 Indirizzo UNIVERSITY AVENUE G12 8QQ Glasgow Mostra sulla mappa Regione Scotland West Central Scotland Glasgow City Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Joe Galloway (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato IOTA Pharmaceuticals Ltd Regno Unito Contributo UE € 545 156,00 Indirizzo COWLEY ROAD ST JOHNS INNOVATION CENTRE CB4 0WS Cambridge Mostra sulla mappa Regione East of England East Anglia Cambridgeshire CC Contatto amministrativo Paul England (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITY OF KENT Regno Unito Contributo UE € 787 968,00 Indirizzo THE REGISTRY CANTERBURY CT2 7NZ Canterbury, Kent Mostra sulla mappa Regione South East (England) Kent East Kent Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Andrew Massoura (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato European ScreeningPort GmbH Partecipazione conclusa Germania Contributo UE € 31 654,72 Indirizzo Schnackenburgallee 22525 Hamburg Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Sheraz Gul (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spagna Contributo UE € 398 664,00 Indirizzo CALLE SERRANO 117 28006 Madrid Mostra sulla mappa Regione Comunidad de Madrid Comunidad de Madrid Madrid Tipo di attività Research Organisations Contatto amministrativo Ana Maria De La Fuente (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Theodor Bilharz Research Institute Egitto Contributo UE € 299 938,00 Indirizzo El Nil street 12411 Giza Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Amr Radwan (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITEIT ANTWERPEN Belgio Contributo UE € 778 548,00 Indirizzo PRINSSTRAAT 13 2000 Antwerpen Mostra sulla mappa Regione Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Anne Adams (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FUNDACAO OSWALDO CRUZ Brasile Contributo UE € 199 419,00 Indirizzo AVENIDA BRASIL 4365 21040 900 Rio De Janeiro Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Maria De Nazaré Correia Soeiro (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato STICHTING LYGATURE Paesi Bassi Contributo UE € 300 000,00 Indirizzo JAARBEURSPLEIN 6 3521 AL Utrecht Mostra sulla mappa Regione West-Nederland Utrecht Utrecht Tipo di attività Other Contatto amministrativo Herman Verheij (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germania Contributo UE € 656 227,28 Indirizzo HANSASTRASSE 27C 80686 Munchen Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Research Organisations Contatto amministrativo Michael Prestele (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato