Cel A central goal in evolutionary biology is to understand the molecular changes responsible for phenotypic differences between species, in particular those that have arisen among mammals. Phenotypic evolution is thought to be largely founded on developmental gene regulatory changes, which determine species-specific tissue morphologies and thus lay the foundation for their typical physiological properties. We recently performed the first cross-mammalian transcriptome comparisons for adult organs, providing many insights into the molecular evolution of organ physiologies, but the evolution of developmental transcriptomes remains largely unstudied. I propose to generate comprehensive RNA sequencing data for a collection of adult tissues and developmental precursors from many mammals and tetrapod outgroup species (birds, reptiles, amphibians). The data will include dense ontogenetic time courses for key reference species, covering embryonic stages and, for mammals, placental tissues. We will identify coding and noncoding genes constituting core ancestral tissue transcriptomes and assess relative contributions of gene expression changes and the emergence of new genes to the evolution of phenotypically relevant expression patterns. We will also empirically evaluate global models of evolutionary conservation patterns during embryogenesis and placentation. To understand the dynamics of functional and regulatory interactions of different gene types and their evolutionary relevance, we will reconstruct evolutionary transcription networks and assess associated regulatory mechanisms. Overall, this inter-disciplinary “evo-devo” project will unveil ontogenetic and adult gene expression programs underlying shared (ancestral) and lineage-specific morphological and physiological phenotypes. It will thus substantially advance our understanding of the molecular basis of phenotypic evolution. Dziedzina nauki natural sciencesbiological sciencesevolutionary biologynatural sciencesbiological sciencesdevelopmental biologynatural sciencesbiological sciencesgeneticsRNAnatural sciencesbiological scienceszoologymammalogynatural sciencesbiological sciencesmolecular biologymolecular evolution Program(-y) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Temat(-y) ERC-CG-2013-LS8 - ERC Consolidator Grant - Evolutionary, Population and Environmental Biology Zaproszenie do składania wniosków ERC-2013-CoG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-CG - ERC Consolidator Grants Instytucja przyjmująca RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Wkład UE € 1 535 488,00 Adres SEMINARSTRASSE 2 69117 Heidelberg Niemcy Zobacz na mapie Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Henrik Kaessmann (Prof.) Kontakt administracyjny Norbert Huber (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych Beneficjenci (2) Sortuj alfabetycznie Sortuj według wkładu UE Rozwiń wszystko Zwiń wszystko RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG Niemcy Wkład UE € 1 535 488,00 Adres SEMINARSTRASSE 2 69117 Heidelberg Zobacz na mapie Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Rodzaj działalności Higher or Secondary Education Establishments Kierownik naukowy Henrik Kaessmann (Prof.) Kontakt administracyjny Norbert Huber (Dr.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych UNIVERSITE DE LAUSANNE Zakończenie uczestnictwa Szwajcaria Wkład UE € 463 144,00 Adres QUARTIER UNIL CENTRE - BATIMENT UNICENTRE 1015 LAUSANNE Zobacz na mapie Region Schweiz/Suisse/Svizzera Région lémanique Vaud Rodzaj działalności Higher or Secondary Education Establishments Kontakt administracyjny Nicole Vouilloz (Ms.) Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Koszt całkowity Brak danych
