Objectif The main objective of VIVOIMAG is to develop bone implants including a new contrast agent sensitive to enzymatic activity of metaloproteases, which will permit for the first time to follow the integration and cell differentiation activity in bone tissue bioreactors in vitro and in grafts in vivo using existing non invasive magnetic resonance imaging techniques. The proposal aims at integrating a magnetically functionalized extracellular matrix material into the bone scaffolds, seeding them with cells, implanting them in animal models and following the fate of the implants in vivo using MRI. The aim is to obtain similar results with the magnetically modified scaffolds as the ones obtained currently but having now endowed the grafts with enzymatic reporting activity that can be monitored noninvasively in the living animal. There are currently no methods to detect in situ and in vivo this enzymatic activity without previously sacrificing the transplanted animals, therefore the successful accomplishment of this project would have huge and prolonged impact in the medical field of tissue regeneration.The VIVOIMAG project brings together a multidisciplinary consortium of specialists in different areas of bone implant research, nanoparticles formulation and characterization, magnetic resonance and scintigraphic imaging, who will join forces in order to propose and assess a novel technique for the evaluation of the progress of bone implants in vivo, which can substitute existing invasive techniques based on biopsies.A well planned exchange program among academic and industrial partners will facilitate knowledge sharing, maximize collaborative work and finally achievement of project objectives. The consortium, being aware of the scientific and social importance of bone tissue engineering, has planned a series of dissemination and training activities, aiming at making project knowledge and outcomes available to the scientific community and society. Champ scientifique medical and health sciencesclinical medicinesurgerymedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesmedical biotechnologynanomedicineengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imagingmedical and health sciencesmedical biotechnologyimplantsartificial bone Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Thème(s) MSCA-RISE-2014 - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Appel à propositions H2020-MSCA-RISE-2014 Voir d’autres projets de cet appel Régime de financement MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinateur "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" Contribution nette de l'UE € 72 000,00 Adresse END OF PATRIARCHOU GRIGORIOU E AND 27 NEAPOLEOS STREET 15341 Agia Paraskevi Grèce Voir sur la carte Région Αττική Aττική Βόρειος Τομέας Αθηνών Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 72 000,00 Participants (7) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Espagne Contribution nette de l'UE € 18 000,00 Adresse CALLE SERRANO 117 28006 Madrid Voir sur la carte Région Comunidad de Madrid Comunidad de Madrid Madrid Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 18 000,00 UNIVERSITE DE MONS Belgique Contribution nette de l'UE € 18 000,00 Adresse PLACE DU PARC 20 7000 Mons Voir sur la carte Région Région wallonne Prov. Hainaut Arr. Mons Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 18 000,00 BONUS THERAPEUTIC LTD Israël Contribution nette de l'UE € 0,00 Adresse 8 A BLDG MATAM ADVANCED TECHNOLOGY PARK 3508408 HAIFA Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total Aucune donnée BIOIMAG SOLUCIONES DE CONTRASTE SL Espagne Contribution nette de l'UE € 103 500,00 Adresse CARRETERA N 521 KM 41,800 10071 CACERES Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Centro (ES) Extremadura Cáceres Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 103 500,00 BIOEMISSION TECHNOLOGY SOLUTIONS IKE Grèce Contribution nette de l'UE € 135 000,00 Adresse L. MESOGEION 387 153 43 AGIA PARASKEVI (ATHINA) Voir sur la carte PME L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention. Oui Région Αττική Aττική Βόρειος Τομέας Αθηνών Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Liens Contacter l’organisation Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 135 000,00 UNIVERSITY OF LEEDS Royaume-Uni Contribution nette de l'UE € 67 500,00 Adresse WOODHOUSE LANE LS2 9JT Leeds Voir sur la carte Région Yorkshire and the Humber West Yorkshire Leeds Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 67 500,00 CONSIGLIO NAZIONALE DELLE RICERCHE Italie Contribution nette de l'UE € 58 500,00 Adresse PIAZZALE ALDO MORO 7 00185 Roma Voir sur la carte Région Centro (IT) Lazio Roma Type d’activité Research Organisations Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 58 500,00