Periodic Reporting for period 1 - Calypso (The next-generation heart pump to change patients’ lives and create a new standard of care)
Berichtszeitraum: 2020-10-01 bis 2021-09-30
To help HF patients return to a fully active life, CorWave develops an LVAD based on a proprietary breakthrough technology. CorWave LVAD is a biomimetic pump that uses a membrane mimicking the undulating motion of marine animals. With this unique technology, CorWave LVAD intends to fully respect the patient's physiology, reduce adverse events, and remove current daily limitations.
Through the EIC Accelerator project, CorWave’s objective is to complete the preclinical work and validate clinically CorWave LVAD.
- CorWave recently achieved a technical milestone in a chronic preclinical in vivo study, representing a world first in LVADs. CorWave LVAD operated for 90 days in pulsatile mode by synchronizing with the native heart. The study also confirmed the excellent hemocompatibility of the CorWave pump.
- Regarding fatigue performance, a key characteristic of LVADs, CorWave's studies on test benches have exceeded 12 months.
Besides, to support CorWave's structuration in its industrial production phase and upcoming clinical trials, the company has succeeded in attracting two international LVAD experts as VP, RAQACA, and VP, Manufacturing.
Based on a breakthrough proprietary technology, CorWave must go beyond the state of the art to deliver the safest, most beneficial LVAD to HF patients and clinicians. To predict the hemocompatibility and hemodynamic performance of different pump designs, CorWave has developed unique simulation tools. The synchronous pulsatility algorithm, which was successfully tested in the recent 90-day in vivo study, is also groundbreaking.
CorWave aims at making a major impact on the treatment of advanced HF patients by offering them excellent survival and improved quality of life. Decreasing rehospitalizations should also reduce the cost of LVAD therapy and improve its adoption, allowing more patients to benefit from this life-saving therapy.
CorWave will also have wider societal impacts, such as a socioeconomic one with job creations, and a scientific one with major progress on mechanical fluid simulations and hydraulic bench testing.