Skip to main content
Aller à la page d’accueil de la Commission européenne (s’ouvre dans une nouvelle fenêtre)
français fr
CORDIS - Résultats de la recherche de l’UE
CORDIS

From cells to systems: Pioneering multi-level thrombosis risk prediction models - “ThromboRisk”

Description du projet

Approche multi-échelle de la thrombose et traitement personnalisé

Les caillots sanguins, ou thromboses, sont responsables d’un décès sur quatre dans le monde. Ils entraînent des accidents vasculaires cérébraux, des crises cardiaques et des blocages veineux. Comprendre comment les caillots se forment, grossissent ou se désagrègent est essentiel pour prédire les résultats et personnaliser les traitements. Soutenu par le programme Actions Marie Skłodowska-Curie, le projet ThromboRisk vise à former des doctorants à l’étude de la thrombose à différents niveaux. Concrètement, il combinera des modèles informatiques, des expériences en laboratoire et des données cliniques. Ce projet permettra de développer des outils pour améliorer les pronostics et les thérapies individualisés. Il préparera également les chercheurs à aborder des problèmes de santé complexes grâce à des solutions novatrices bénéfiques pour la société.

Objectif

"Thrombosis, an occlusive blood clot, underlies ischemic stroke, myocardial infarction, and venous thrombosis, causing 1 in 4 deaths globally. Its incidence is rising due to an increasingly aging population and increased cardiovascular diseases, along with more cardiovascular implants. Unfortunately, limited understanding of thrombus formation, growth, and rupture hampers patient-specific prognosis. Current treatment strategies include antithrombotic therapy and thrombectomy, but improvements are needed for patient-specific treatments due to common recurrence and unknown impacts on clot fragmentation and thromboembolism.
To effectively understand disease mechanisms and accurately predict treatment outcomes, it is crucial to integrate knowledge across multiple scales, harnessing a diverse range of cutting-edge in silico, in vitro, and in vivo technologies. This powerful fusion of emerging technologies holds the potential to revolutionize targeted and personalized medicine. However, there remains a significant shortage of trained professionals capable of co-creating such comprehensive and holistic disease models.
ThromboRisk will therefore train 18 exceptional doctoral candidates (DCs) in diverse scientific fields, including mechanobiology, biochemistry, pathophysiology, and modeling. These researchers will collaborate within an international and interdisciplinary consortium to develop a platform advancing our understanding of thrombosis across scales, hereby bridging the gap between micro-level thrombus processes and macro-level impacts on disease prognosis, enabling clinical application.
Unlike traditional engineering curricula, which address well-defined problems, ThromboRisk tackles complex, multifactorial ""wicked problems"" in fields of thrombosis by implementing a Challenge-Based Learning (CBL) doctoral training program to foster creativity, innovation, and societal impact. CBL is growing in undergraduate education but remains underdeveloped in doctoral training, where it has the potential to encourage DCs to step outside their comfort zones, think creatively, manage risks, and use technology responsibly in problem-solving. The DCs will work on real-world problems with peers, supervisors, consortium members, and external stakeholders, who act as ""real clients"" and co-creators."

Champ scientifique (EuroSciVoc)

Mots‑clés

Programme(s)

Thème(s)

Régime de financement

HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks

Voir tous les projets financés dans le cadre de ce programme de financement

Appel à propositions

(s’ouvre dans une nouvelle fenêtre) HORIZON-MSCA-2024-DN-01

Voir tous les projets financés au titre de cet appel

Coordinateur

TECHNISCHE UNIVERSITEIT EINDHOVEN
Contribution nette de l'UE
€ 610 571,52
Adresse
GROENE LOPER 3
5612 AE Eindhoven
Pays-Bas
Région
Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
Aucune donnée

Participants (8)

Partenaires (9)