Aging Lungs in European Cohorts

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Study Website

ALEC website

Consortium Publication Policy

Publication policy

Data Managment Plan (early)

Data managment plan for the consortium

Directory of stakeholders

A list of stakeholders with an interest in ALEC work and output For inclusion in monthyly briefing see WP1

Pamphlet describing study aims and objectives available to partners for disemination

Pamphlet for dissemination describing study aims and objectives

Publications

Childhood Lung Function Predicts Adult Chronic Obstructive Pulmonary Disease and Asthma–Chronic Obstructive Pulmonary Disease Overlap Syndrome

Auteurs: Dinh S. Bui, John A. Burgess, Adrian J. Lowe, Jennifer L. Perret, Caroline J. Lodge, Minh Bui, Stephen Morrison, Bruce R. Thompson, Paul S. Thomas, Graham G. Giles, Judith Garcia-Aymerich, Debbie Jarvis, Michael J. Abramson, E. Haydn Walters, Melanie C. Matheson, Shyamali C. Dharmage
Publié dans: American Journal of Respiratory and Critical Care Medicine, Numéro 196/1, 2017, Page(s) 39-46, ISSN 1073-449X
Éditeur: American Thoracic Society
DOI: 10.1164/rccm.201606-1272oc

A three-generation study on the association of tobacco smoking with asthma

Auteurs: Simone Accordini, Lucia Calciano, Ane Johannessen, Laura Portas, Bryndis Benediktsdóttir, Randi Jacobsen Bertelsen, Lennart Bråbäck, Anne-Elie Carsin, Shyamali C Dharmage, Julia Dratva, Bertil Forsberg, Francisco Gomez Real, Joachim Heinrich, John W Holloway, Mathias Holm, Christer Janson, Rain Jögi, Bénédicte Leynaert, Andrei Malinovschi, Alessandro Marcon, Jesús Martínez-Moratalla Rovira
Publié dans: International Journal of Epidemiology, 2018, ISSN 0300-5771
Éditeur: Oxford University Press
DOI: 10.1093/ije/dyy031

Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study

Auteurs: Elaine Fuertes, Anne-Elie Carsin, Josep M Antó, Roberto Bono, Angelo Guido Corsico, Pascal Demoly, Thorarinn Gislason, José-Antonio Gullón, Christer Janson, Deborah Jarvis, Joachim Heinrich, Mathias Holm, Bénédicte Leynaert, Alessandro Marcon, Jesús Martinez-Moratalla, Dennis Nowak, Silvia Pascual Erquicia, Nicole M Probst-Hensch, Chantal Raherison, Wasif Raza, Francisco Gómez Real, Melissa
Publié dans: Thorax, Numéro 73/4, 2018, Page(s) 376-384, ISSN 0040-6376
Éditeur: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2017-210947

Dietary antioxidants and 10-year lung function decline in adults from the ECRHS survey

Auteurs: Vanessa Garcia-Larsen, James F. Potts, Ernst Omenaas, Joachim Heinrich, Cecilie Svanes, Judith Garcia-Aymerich, Peter G. Burney, Deborah L. Jarvis
Publié dans: European Respiratory Journal, Numéro 50/6, 2017, Page(s) 1602286, ISSN 0903-1936
Éditeur: European Respiratory Society
DOI: 10.1183/13993003.02286-2016

Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study

Auteurs: Alessandro Marcon, Francesca Locatelli, Dirk Keidel, Anna B Beckmeyer-Borowko, Isa Cerveri, Shyamali C Dharmage, Elaine Fuertes, Judith Garcia-Aymerich, Joachim Heinrich, Medea Imboden, Christer Janson, Ane Johannessen, Bénédicte Leynaert, Silvia Pascual Erquicia, Giancarlo Pesce, Emmanuel Schaffner, Cecilie Svanes, Isabel Urrutia, Deborah Jarvis, Nicole M Probst-Hensch, Simone Accordini
Publié dans: Thorax, 2018, Page(s) thoraxjnl-2017-211289, ISSN 0040-6376
Éditeur: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2017-211289

Age at menarche and lung function: a Mendelian randomization study

Auteurs: Dipender Gill, Nuala A. Sheehan, Matthias Wielscher, Nick Shrine, Andre F. S. Amaral, John R. Thompson, Raquel Granell, Bénédicte Leynaert, Francisco Gómez Real, Ian P. Hall, Martin D. Tobin, Juha Auvinen, Susan M. Ring, Marjo-Riitta Jarvelin, Louise V. Wain, John Henderson, Deborah Jarvis, Cosetta Minelli
Publié dans: European Journal of Epidemiology, Numéro 32/8, 2017, Page(s) 701-710, ISSN 0393-2990
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10654-017-0272-9

Clinical markers of asthma and IgE assessed in parents before conception predict asthma and hayfever in the offspring

Auteurs: R. J. Bertelsen, M. Rava, A. E. Carsin, S. Accordini, B. Benediktsdóttir, J. Dratva, K. A. Franklin, J. Heinrich, M. Holm, C. Janson, A. Johannessen, D. L. Jarvis, R. Jogi, B. Leynaert, D. Norback, E. R. Omenaas, C. Raherison, J. L. Sánchez-Ramos, V. Schlünssen, T. Sigsgaard, S. C. Dharmage, C. Svanes
Publié dans: Clinical & Experimental Allergy, Numéro 47/5, 2017, Page(s) 627-638, ISSN 0954-7894
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cea.12906

Respiratory symptoms are more common among short sleepers independent of obesity

Auteurs: Erla Björnsdóttir, Christer Janson, Eva Lindberg, Erna Sif Arnardottir, Bryndís Benediktsdóttir, Judith Garcia-Aymerich, Anne Elie Carsin, Francisco Gómez Real, Kjell Torén, Joachim Heinrich, Dennis Nowak, José Luis Sánchez-Ramos, Pascal Demoly, Sandra Dorado Arenas, Ramon Coloma Navarro, Vivi Schlünssen, Chantal Raherison, Debbie L Jarvis, Thorarinn Gislason
Publié dans: BMJ Open Respiratory Research, Numéro 4/1, 2017, Page(s) e000206, ISSN 2052-4439
Éditeur: BMJ
DOI: 10.1136/bmjresp-2017-000206

Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies

Auteurs: Matthew Machin, André F. S. Amaral, Matthias Wielscher, Faisal I. Rezwan, Medea Imboden, Marjo-Riitta Jarvelin, Ian M. Adcock, Nicole Probst-Hensch, John W. Holloway, Deborah L. Jarvis
Publié dans: BMC Pulmonary Medicine, Numéro 17/1, 2017, ISSN 1471-2466
Éditeur: BioMed Central
DOI: 10.1186/s12890-017-0397-3

Zoonotic helminth exposure and risk of allergic diseases: A study of two generations in Norway

Auteurs: N. O. Jõgi, C. Svanes, S. P. Siiak, E. Logan, J. W. Holloway, J. Igland, A. Johannessen, M. Levin, F. G. Real, V. Schlunssen, W. G. C. Horsnell, R. J. Bertelsen
Publié dans: Clinical & Experimental Allergy, Numéro 48/1, 2018, Page(s) 66-77, ISSN 0954-7894
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/cea.13055

Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life

Auteurs: Dinh S Bui, Caroline J Lodge, John A Burgess, Adrian J Lowe, Jennifer Perret, Minh Q Bui, Gayan Bowatte, Lyle Gurrin, David P Johns, Bruce R Thompson, Garun S Hamilton, Peter A Frith, Alan L James, Paul S Thomas, Deborah Jarvis, Cecilie Svanes, Melissa Russell, Stephen C Morrison, Iain Feather, Katrina J Allen, Richard Wood-Baker, John Hopper, Graham G Giles, Michael J Abramson, Eugene H Walters,
Publié dans: The Lancet Respiratory Medicine, 2018, ISSN 2213-2600
Éditeur: Elsevier Limited
DOI: 10.1016/S2213-2600(18)30100-0

Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey

Auteurs: Theodore Lytras, Manolis Kogevinas, Hans Kromhout, Anne-Elie Carsin, Josep M Antó, Hayat Bentouhami, Joost Weyler, Joachim Heinrich, Dennis Nowak, Isabel Urrutia, Jesús Martinez-Moratalla, José Antonio Gullón, Antonio Pereira-Vega, Chantal Raherison-Semjen, Isabelle Pin, Pascal Demoly, Bénédicte Leynaert, Simona Villani, Thorarinn Gislason, Cecilie Svanes, Mathias Holm, Bertil Forsberg, Dan
Publié dans: Thorax, 2018, Page(s) thoraxjnl-2017-211158, ISSN 0040-6376
Éditeur: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2017-211158

Body silhouettes as a tool to reflect obesity in the past

Auteurs: Marianne Lønnebotn, Cecilie Svanes, Jannicke Igland, Karl A. Franklin, Simone Accordini, Bryndís Benediktsdóttir, Hayat Bentouhami, José A. G. Blanco, Roberto Bono, Angelo Corsico, Pascal Demoly, Shyamali Dharmage, Sandra Dorado Arenas, Judith Garcia, Joachim Heinrich, Mathias Holm, Christer Janson, Debbie Jarvis, Bénédicte Leynaert, Jesús Martinez-Moratalla, Dennis Nowak, Isabelle Pin, Cha
Publié dans: PLOS ONE, Numéro 13/4, 2018, Page(s) e0195697, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0195697

Prediction models for the development of COPD: a systematic review

Auteurs: Melanie Matheson, Gayan Bowatte, Jennifer Perret, Adrian Lowe, Chamara Senaratna, Graham Hall, Nick de Klerk, Louise Keogh, Christine McDonald, Nilakshi T Waidyatillake, Peter Sly, Deborah Jarvis, Michael Abramson, Caroline Lodge, Shyamali Dharmage
Publié dans: International Journal of Chronic Obstructive Pulmonary Disease, Numéro Volume 13, 2018, Page(s) 1927-1935, ISSN 1178-2005
Éditeur: DovePress
DOI: 10.2147/COPD.S155675

Age at puberty and risk of asthma: A Mendelian randomisation study

Auteurs: Cosetta Minelli, Diana A. van der Plaat, Bénédicte Leynaert, Raquel Granell, Andre F. S. Amaral, Miguel Pereira, Osama Mahmoud, James Potts, Nuala A. Sheehan, Jack Bowden, John Thompson, Debbie Jarvis, George Davey Smith, John Henderson
Publié dans: PLOS Medicine, Numéro 15/8, 2018, Page(s) e1002634, ISSN 1549-1676
Éditeur: PloS Medicine
DOI: 10.1371/journal.pmed.1002634

Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study

Auteurs: Elaine Fuertes, Iana Markevych, Deborah Jarvis, Danielle Vienneau, Kees de Hoogh, Josep Maria Antó, Gayan Bowatte, Roberto Bono, Angelo G. Corsico, Margareta Emtner, Thorarinn Gislason, José Antonio Gullón, Joachim Heinrich, John Henderson, Mathias Holm, Ane Johannessen, Bénédicte Leynaert, Alessandro Marcon, Pierpaolo Marchetti, Jesús Martínez Moratalla, Silvia Pascual, Nicole Probst-Hensc
Publié dans: Environment International, Numéro 120, 2018, Page(s) 364-372, ISSN 0160-4120
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/J.ENVINT.2018.07.032

Occupational exposure to solvents and lung function decline: A population based study

Auteurs: Sheikh M Alif, Shyamali Dharmage, Geza Benke, Martine Dennekamp, John Burgess, Jennifer L Perret, Caroline Lodge, Stephen Morrison, David Peter Johns, Graham Giles, Lyle Gurrin, Paul S Thomas, John Llewelyn Hopper, Richard Wood-Baker, Bruce Thompson, Iain Feather, Roel Vermeulen, Hans Kromhout, Debbie Jarvis, Judith Garcia Aymerich, E Haydn Walters, Michael J Abramson, Melanie Claire Matheson
Publié dans: Thorax, 2019, Page(s) thoraxjnl-2018-212267, ISSN 0040-6376
Éditeur: BMJ Publishing Group
DOI: 10.1136/thoraxjnl-2018-212267

DNA Methylation in Inflammatory Pathways Modifies the Association between BMI and Adult-Onset Non-Atopic Asthma

Auteurs: Ayoung Jeong, Medea Imboden, Akram Ghantous, Alexei Novoloaca, Anne-Elie Carsin, Manolis Kogevinas, Christian Schindler, Gianfranco Lovison, Zdenko Herceg, Cyrille Cuenin, Roel Vermeulen, Deborah Jarvis, André Amaral, Florian Kronenberg, Paolo Vineis, Nicole Probst-Hensch
Publié dans: International Journal of Environmental Research and Public Health, Numéro 16/4, 2019, Page(s) 600, ISSN 1660-4601
Éditeur: MDPI
DOI: 10.3390/ijerph16040600

Exogenous female sex steroids may reduce lung ageing after menopause: A 20-year follow-up study of a general population sample (ECRHS)

Auteurs: Kai Triebner, Simone Accordini, Lucia Calciano, Ane Johannessen, Bryndís Benediktsdóttir, Ersilia Bifulco, Pascal Demoly, Shyamali C. Dharmage, Karl A. Franklin, Judith Garcia-Aymerich, José Antonio Gullón Blanco, Joachim Heinrich, Mathias Holm, Debbie Jarvis, Rain Jõgi, Eva Lindberg, Jesús Martínez-Moratalla, Nerea Muniozguren Agirre, Isabelle Pin, Nicole Probst-Hensch, Chantal Raherison,
Publié dans: Maturitas, Numéro 120, 2019, Page(s) 29-34, ISSN 0378-5122
Éditeur: Elsevier BV
DOI: 10.1016/j.maturitas.2018.11.007

Time and age trends in smoking cessation in Europe

Auteurs: Giancarlo Pesce, Alessandro Marcon, Lucia Calciano, Jennifer L. Perret, Michael J. Abramson, Roberto Bono, Jean Bousquet, Alessandro G. Fois, Christer Janson, Deborah Jarvis, Rain Jõgi, Bénédicte Leynaert, Dennis Nowak, Vivi Schlünssen, Isabel Urrutia-Landa, Giuseppe Verlato, Simona Villani, Torsten Zuberbier, Cosetta Minelli, Simone Accordini
Publié dans: PLOS ONE, Numéro 14/2, 2019, Page(s) e0211976, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0211976

Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

Auteurs: Anne-Elie Carsin, Elaine Fuertes, Emmanuel Schaffner, Debbie Jarvis, Josep M. Antó, Joachim Heinrich, Valeria Bellisario, Cecilie Svanes, Dirk Keidel, Medea Imboden, Joost Weyler, Dennis Nowak, Jesus Martinez-Moratalla, José-Antonio Gullón, José Luis Sanchez Ramos, Seraina Caviezel, Anna Beckmeyer-Borowko, Chantal Raherison, Isabelle Pin, Pascal Demoly, Isa Cerveri, Simone Accordini, Thorarinn
Publié dans: Respiratory Medicine, Numéro 146, 2019, Page(s) 116-123, ISSN 0954-6111
Éditeur: W. B. Saunders Co., Ltd.
DOI: 10.1016/j.rmed.2018.11.017

Trends in smoking initiation in Europe over 40 years: A retrospective cohort study

Auteurs: Alessandro Marcon, Giancarlo Pesce, Lucia Calciano, Valeria Bellisario, Shyamali C. Dharmage, Judith Garcia-Aymerich, Thorarinn Gislasson, Joachim Heinrich, Mathias Holm, Christer Janson, Deborah Jarvis, Bénédicte Leynaert, Melanie C. Matheson, Pietro Pirina, Cecilie Svanes, Simona Villani, Torsten Zuberbier, Cosetta Minelli, Simone Accordini
Publié dans: PLOS ONE, Numéro 13/8, 2018, Page(s) e0201881, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0201881

Association of Height Growth in Puberty with Lung Function. A Longitudinal Study

Auteurs: Osama Mahmoud, Raquel Granell, Kate Tilling, Cosetta Minelli, Judith Garcia-Aymerich, John W. Holloway, Adnan Custovic, Deborah Jarvis, Jonathan Sterne, John Henderson
Publié dans: American Journal of Respiratory and Critical Care Medicine, Numéro 198/12, 2018, Page(s) 1539-1548, ISSN 1073-449X
Éditeur: American Thoracic Society
DOI: 10.1164/rccm.201802-0274oc

Childhood Respiratory Risk Factor Profiles and Middle-Age Lung Function: A Prospective Cohort Study from the First to Sixth Decade

Auteurs: Dinh S. Bui, Haydn E. Walters, John A. Burgess, Jennifer L. Perret, Minh Q. Bui, Gayan Bowatte, Adrian J. Lowe, Melissa A. Russell, Bruce R. Thompson, Garun S. Hamilton, Alan L. James, Graham G. Giles, Paul S. Thomas, Debbie Jarvis, Cecilie Svanes, Judith Garcia-Aymerich, Bircan Erbas, Peter A. Frith, Katrina J. Allen, Michael J. Abramson, Caroline J. Lodge, Shyamali C. Dharmage
Publié dans: Annals of the American Thoracic Society, Numéro 15/9, 2018, Page(s) 1057-1066, ISSN 2325-6621
Éditeur: American Thoracic Society
DOI: 10.1513/annalsats.201806-374oc

Childhood Body Composition Trajectories and Adolescent Lung Function: Findings from the ALSPAC Study

Auteurs: Gabriela P Peralta, Elaine Fuertes, Raquel Granell, Osama Mahmoud, Célina Roda, Ignasi Serra, Deborah Jarvis, John Henderson, Judith Garcia-Aymerich
Publié dans: American Journal of Respiratory and Critical Care Medicine, 2019, ISSN 1073-449X
Éditeur: American Thoracic Society
DOI: 10.1164/rccm.201806-1168oc

SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts

Auteurs: Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, Andre F. S. Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos, Gemma C. Sharp, Caroline Relton, Alexander J. Henderson, Marjo-Riitta Jarvelin, Deborah Jarvis, John W. Holloway, Nicole M. Pr
Publié dans: Respiratory Research, Numéro 19/1, 2018, ISSN 1465-993X
Éditeur: BioMed Central
DOI: 10.1186/s12931-018-0850-8

Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms

Auteurs: Össur Ingi Emilsson, Shadi Amid Hägg, Eva Lindberg, Karl A. Franklin, Kjell Toren, Bryndis Benediktsdottir, Thor Aspelund, Francisco Gómez Real, Bénédicte Leynaert, Pascal Demoly, Torben Sigsgaard, Jennifer Perret, Andrei Malinovschi, Deborah Jarvis, Judith Garcia-Aymerich, Thorarinn Gislason, Christer Janson
Publié dans: ERJ Open Research, Numéro 5/2, 2019, Page(s) 00010-2019, ISSN 2312-0541
Éditeur: ERS
DOI: 10.1183/23120541.00010-2019

Epigenome-wide association study of lung function level and its change

Auteurs: Imboden, M
Publié dans: European Respiratory Journal, 2019, ISSN 0903-1936
Éditeur: European Respiratory Society

Transgenerational and intergenerational epigenetic inheritance in allergic diseases

Auteurs: Toril Mørkve Knudsen, Faisal I. Rezwan, Yu Jiang, Wilfried Karmaus, Cecilie Svanes, John W. Holloway
Publié dans: Journal of Allergy and Clinical Immunology, Numéro 142/3, 2018, Page(s) 765-772, ISSN 0091-6749
Éditeur: Mosby Inc.
DOI: 10.1016/j.jaci.2018.07.007

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