The continuum between healthy ageing and idiopathic Parkinson Disease within a propagation perspective of inflammation and damage: the search for new diagnostic, prognostic and therapeutic targets

Informations projet

PROPAG-AGEING

N° de convention de subvention: 634821

DOI

10.3030/634821

Projet clôturé

Date de signature de la CE 7 Avril 2015

Date de début 1 Septembre 2015

Date de fin 31 Août 2019

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 5 993 376,00

Contribution de l’UE

€ 5 993 376,00

Coordonné par

AZIENDA UNITA' SANITARIA LOCALE DI BOLOGNA
Italy

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (1)

Plan for Using and Disseminating Foreground

A final Plan for Disseminating and Using of Foreground will be produced at the end of the project (M48).

Websites, patent fillings, videos etc. (1)

Project website

The structure of the PROPAG-AGEING website will have to be developed in consultation with all Participants: anyway, top-level areas are likely to providing general information, announcements, bulletin boards, and discussion forums, etc.; they will include sub-domains for each WP, with access control options. Once the site has been created, the ongoing work will mainly require maintenance and update of the website server and of its contents, on the one hand, and security operations (protection against attack from hackers and spammers), on the other hand. The website will include a reserved area for the Participants’ access only that will be used to exchange information and documents among the Participants.

Publications

Peer reviewed articles (37)

A frailty index for UK Biobank participants

Auteurs: Hagg, Sara; Pedersen, Nancy; Jylhava, Juulia; Williams, Dylan
Publié dans: The journals of gerontology. Series A, Biological sciences and medical sciences., Numéro 2, 2018, ISSN 1758-535X
Éditeur: Oxford University Press
DOI: 10.1101/233692

Circulating insulin-like growth factors and Alzheimer disease

Auteurs: Dylan M. Williams, Ida K. Karlsson, Nancy L. Pedersen, Sara Hägg
Publié dans: Neurology, Numéro 90/4, 2018, Page(s) e291-e297, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/WNL.0000000000004854

Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity

Auteurs: Claudio Franceschi, Stefano Salvioli, Paolo Garagnani, Magda de Eguileor, Daniela Monti, Miriam Capri
Publié dans: Frontiers in Immunology, Numéro 8, 2017, ISSN 1664-3224
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fimmu.2017.00982

"Acceleration of leukocytes’ epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer"

Auteurs: Danielle Fernandes Durso, Maria Giulia Bacalini, Claudia Sala, Chiara Pirazzini, Elena Marasco, Massimiliano Bonafé, Ítalo Faria do Valle, Davide Gentilini, Gastone Castellani, Ana Maria Caetano Faria, Claudio Franceschi, Paolo Garagnani, Christine Nardini
Publié dans: Oncotarget, Numéro 8/14, 2017, ISSN 1949-2553
Éditeur: Impact Journals
DOI: 10.18632/oncotarget.15573

Gelified Biofluids for High-Resolution Magic Angle Spinning 1 H NMR Analysis: The Case of Urine

Auteurs: Panteleimon G. Takis, Leonardo Tenori, Enrico Ravera, Claudio Luchinat
Publié dans: Analytical Chemistry, Numéro 89/2, 2016, Page(s) 1054-1058, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.6b04318

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

Auteurs: Maria Giulia Bacalini, Joris Deelen, Chiara Pirazzini, Marco De Cecco, Cristina Giuliani, Catia Lanzarini, Francesco Ravaioli, Elena Marasco, Diana van Heemst, H. Eka D. Suchiman, Roderick Slieker, Enrico Giampieri, Rina Recchioni, Fiorella Mercheselli, Stefano Salvioli, Giovanni Vitale, Fabiola Olivieri, Annemieke M. W. Spijkerman, Martijn E. T. Dollé, John M. Sedivy, Gastone Castellani, Claudio
Publié dans: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2017, Page(s) glw185, ISSN 1079-5006
Éditeur: Gerontological Society of America
DOI: 10.1093/gerona/glw185

Deconvoluting interrelationships between concentrations and chemical shifts in urine provides a powerful analysis tool

Auteurs: Panteleimon G. Takis, Hartmut Schäfer, Manfred Spraul, Claudio Luchinat
Publié dans: Nature Communications, Numéro 8/1, 2017, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-017-01587-0

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Auteurs: Aurelia Santoro, Rita Ostan, Marco Candela, Elena Biagi, Patrizia Brigidi, Miriam Capri, Claudio Franceschi
Publié dans: Cellular and Molecular Life Sciences, Numéro 75/1, 2018, Page(s) 129-148, ISSN 1420-682X
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00018-017-2674-y

Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly

Auteurs: Francesco Ravaioli, Maria Bacalini, Claudio Franceschi, Paolo Garagnani
Publié dans: Genes, Numéro 9/1, 2018, Page(s) 39, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes9010039

Implementing a method for studying longitudinal DNA methylation variability in association with age

Auteurs: Yunzhang Wang, Nancy L. Pedersen, Sara Hägg
Publié dans: Epigenetics, Numéro 13/8, 2018, Page(s) 866-874, ISSN 1559-2294
Éditeur: Landes Bioscience
DOI: 10.1080/15592294.2018.1521222

The epigenetic landscape of age-related diseases: the geroscience perspective

Auteurs: Noémie Gensous, Maria Giulia Bacalini, Chiara Pirazzini, Elena Marasco, Cristina Giuliani, Francesco Ravaioli, Giacomo Mengozzi, Claudia Bertarelli, Maria Giustina Palmas, Claudio Franceschi, Paolo Garagnani
Publié dans: Biogerontology, Numéro 18/4, 2017, Page(s) 549-559, ISSN 1389-5729
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10522-017-9695-7

Impact of demography and population dynamics on the genetic architecture of human longevity

Auteurs: Cristina Giuliani, Marco Sazzini, Chiara Pirazzini, Maria Giulia Bacalini, Elena Marasco, Guido Alberto Gnecchi Ruscone, Fang Fang, Stefania Sarno, Davide Gentilini, Anna Maria Di Blasio, Paolina Crocco, Giuseppe Passarino, Daniela Mari, Daniela Monti, Benedetta Nacmias, Sandro Sorbi, Carlo Salvarani, Mariagrazia Catanoso, Davide Pettener, Donata Luiselli, Svetlana Ukraintseva, Anatoliy Yashin, Cl
Publié dans: Aging, 2018, ISSN 1945-4589
Éditeur: Impact Journals, LLC
DOI: 10.18632/aging.101515

The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson's Disease

Auteurs: Claire Halsband, Antonia Zapf, Friederike Sixel-Döring, Claudia Trenkwalder, Brit Mollenhauer
Publié dans: Movement Disorders Clinical Practice, Numéro 5/2, 2018, Page(s) 171-176, ISSN 2330-1619
Éditeur: Wiley
DOI: 10.1002/mdc3.12591

Genome-wide DNA methylation analysis in blood cells from patients with Werner syndrome

Auteurs: T. Guastafierro, M. G. Bacalini, A. Marcoccia, D. Gentilini, S. Pisoni, A. M. Di Blasio, A. Corsi, C. Franceschi, D. Raimondo, A. Spanò, P. Garagnani, F. Bondanini
Publié dans: Clinical Epigenetics, Numéro 9/1, 2017, ISSN 1868-7075
Éditeur: Springer Verlag
DOI: 10.1186/s13148-017-0389-4

The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates

Auteurs: Claudio Franceschi, Paolo Garagnani, Cristina Morsiani, Maria Conte, Aurelia Santoro, Andrea Grignolio, Daniela Monti, Miriam Capri, Stefano Salvioli
Publié dans: Frontiers in Medicine, Numéro 5, 2018, ISSN 2296-858X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fmed.2018.00061

Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring

Auteurs: Steve Horvath, Chiara Pirazzini, Maria Giulia Bacalini, Davide Gentilini, Anna Maria Di Blasio, Massimo Delledonne, Daniela Mari, Beatrice Arosio, Daniela Monti, Giuseppe Passarino, Francesco De Rango, Patrizia D'Aquila, Cristina Giuliani, Elena Marasco, Sebastiano Collino, Patrick Descombes, Paolo Garagnani, Claudio Franceschi
Publié dans: Aging, Numéro 7/12, 2015, Page(s) 1159-1170, ISSN 1945-4589
Éditeur: Impact Journals, LLC
DOI: 10.18632/aging.100861

Antemortem Prediction of Braak Stage

Auteurs: Jesper O.E. Carlson, Margaret Gatz, Nancy L. Pedersen, Caroline Graff, Inger Nennesmo, Anna-Karin Lindström, Lotte Gerritsen
Publié dans: Journal of Neuropathology & Experimental Neurology, Numéro 74/11, 2015, Page(s) 1061-1070, ISSN 0022-3069
Éditeur: American Association of Neuropathologists, Inc.
DOI: 10.1097/NEN.0000000000000251

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

Auteurs: Vittorio Calabrese, Aurelia Santoro, Daniela Monti, Rosalia Crupi, Rosanna Di Paola, Saverio Latteri, Salvatore Cuzzocrea, Mario Zappia, James Giordano, Edward J. Calabrese, Claudio Franceschi
Publié dans: Free Radical Biology and Medicine, Numéro 115, 2018, Page(s) 80-91, ISSN 0891-5849
Éditeur: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2017.10.379

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature

Auteurs: Maria Giulia Bacalini, Claudio Franceschi, Davide Gentilini, Francesco Ravaioli, Xiaoyuan Zhou, Daniel Remondini, Chiara Pirazzini, Cristina Giuliani, Elena Marasco, Noémie Gensous, Anna Maria Di Blasio, Ewa Ellis, Roberto Gramignoli, Gastone Castellani, Miriam Capri, Stephen Strom, Christine Nardini, Matteo Cescon, Gian Luca Grazi, Paolo Garagnani
Publié dans: The Journals of Gerontology: Series A, 2018, ISSN 1079-5006
Éditeur: Gerontological Society of America
DOI: 10.1093/gerona/gly048

Nutrition and Inflammation: Are Centenarians Similar to Individuals on Calorie-Restricted Diets?

Auteurs: Claudio Franceschi, Rita Ostan, Aurelia Santoro
Publié dans: Annual Review of Nutrition, Numéro 38/1, 2018, Page(s) 329-356, ISSN 0199-9885
Éditeur: Annual Reviews, Inc.
DOI: 10.1146/annurev-nutr-082117-051637

The peculiar aging of human liver: A geroscience perspective within transplant context

Auteurs: Cristina Morsiani, Maria Giulia Bacalini, Aurelia Santoro, Paolo Garagnani, Salvatore Collura, Antonia D’Errico, Magda de Eguileor, Gian Luca Grazi, Matteo Cescon, Claudio Franceschi, Miriam Capri
Publié dans: Ageing Research Reviews, Numéro 51, 2019, Page(s) 24-34, ISSN 1568-1637
Éditeur: Elsevier BV
DOI: 10.1016/j.arr.2019.02.002

Human Aging and Longevity Are Characterized by High Levels of Mitokines

Auteurs: Maria Conte, Rita Ostan, Cristina Fabbri, Aurelia Santoro, Giulia Guidarelli, Giovanni Vitale, Daniela Mari, Federica Sevini, Miriam Capri, Marco Sandri, Daniela Monti, Claudio Franceschi, Stefano Salvioli
Publié dans: The Journals of Gerontology: Series A, Numéro 74/5, 2018, Page(s) 600-607, ISSN 1079-5006
Éditeur: Gerontological Society of America
DOI: 10.1093/gerona/gly153

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Auteurs: Claudio Franceschi, Paolo Garagnani, Paolo Parini, Cristina Giuliani, Aurelia Santoro
Publié dans: Nature Reviews Endocrinology, Numéro 14/10, 2018, Page(s) 576-590, ISSN 1759-5029
Éditeur: Nature Publishing Group
DOI: 10.1038/s41574-018-0059-4

Hormetic approaches to the treatment of Parkinson's disease: Perspectives and possibilities

Auteurs: Vittorio Calabrese, Aurelia Santoro, Angela Trovato Salinaro, Sergio Modafferi, Maria Scuto, Ferdaous Albouchi, Daniela Monti, James Giordano, Mario Zappia, Claudio Franceschi, Edward J Calabrese
Publié dans: Journal of Neuroscience Research, Numéro 96/10, 2018, Page(s) 1641-1662, ISSN 0360-4012
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/jnr.24244

Association of pre-pregnancy body mass index with offspring metabolic profile: Analyses of 3 European prospective birth cohorts

Auteurs: Diana L. Santos Ferreira, Dylan M. Williams, Antti J. Kangas, Pasi Soininen, Mika Ala-Korpela, George Davey Smith, Marjo-Riitta Jarvelin, Debbie A. Lawlor
Publié dans: PLOS Medicine, Numéro 14/8, 2017, Page(s) e1002376, ISSN 1549-1676
Éditeur: Public Library of Science
DOI: 10.1371/journal.pmed.1002376

The Dual Role of the Pervasive “Fattish” Tissue Remodeling With Age

Auteurs: Maria Conte, Morena Martucci, Marco Sandri, Claudio Franceschi, Stefano Salvioli
Publié dans: Frontiers in Endocrinology, Numéro 10, 2019, ISSN 1664-2392
Éditeur: Frontiers
DOI: 10.3389/fendo.2019.00114

Accelerated bio‐cognitive aging in Down syndrome: State of the art and possible deceleration strategies

Auteurs: Claudio Franceschi, Paolo Garagnani, Noémie Gensous, Maria Giulia Bacalini, Maria Conte, Stefano Salvioli
Publié dans: Aging Cell, Numéro 18/3, 2019, Page(s) e12903, ISSN 1474-9718
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/acel.12903

The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity

Auteurs: Paolo Abondio, Marco Sazzini, Paolo Garagnani, Alessio Boattini, Daniela Monti, Claudio Franceschi, Donata Luiselli, Cristina Giuliani
Publié dans: Genes, Numéro 10/3, 2019, Page(s) 222, ISSN 2073-4425
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes10030222

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians

Auteurs: Gianluca Storci, Sabrina De Carolis, Alessio Papi, Maria Giulia Bacalini, Noémie Gensous, Elena Marasco, Anna Tesei, Francesco Fabbri, Chiara Arienti, Michele Zanoni, Anna Sarnelli, Spartaco Santi, Fabiola Olivieri, Emanuela Mensà, Silvia Latini, Manuela Ferracin, Stefano Salvioli, Paolo Garagnani, Claudio Franceschi, Massimiliano Bonafè
Publié dans: Cell Death & Differentiation, Numéro 26/9, 2019, Page(s) 1845-1858, ISSN 1350-9047
Éditeur: Nature Publishing Group
DOI: 10.1038/s41418-018-0255-8

Plasma and urinary metabolomic profiles of Down syndrome correlate with alteration of mitochondrial metabolism

Auteurs: Maria Caracausi, Veronica Ghini, Chiara Locatelli, Martina Mericio, Allison Piovesan, Francesca Antonaros, Maria Chiara Pelleri, Lorenza Vitale, Rosa Anna Vacca, Federica Bedetti, Maria Chiara Mimmi, Claudio Luchinat, Paola Turano, Pierluigi Strippoli, Guido Cocchi
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-20834-y

NMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort

Auteurs: Alessia Vignoli, Leonardo Tenori, Betti Giusti, Panteleimon G. Takis, Serafina Valente, Nazario Carrabba, Daniela Balzi, Alessandro Barchielli, Niccolò Marchionni, Gian Franco Gensini, Rossella Marcucci, Claudio Luchinat, Anna Maria Gori
Publié dans: BMC Medicine, Numéro 17/1, 2019, ISSN 1741-7015
Éditeur: BioMed Central
DOI: 10.1186/s12916-018-1240-2

Uniqueness of the NMR approach to metabolomics

Auteurs: Panteleimon G. Takis, Veronica Ghini, Leonardo Tenori, Paola Turano, Claudio Luchinat
Publié dans: TrAC Trends in Analytical Chemistry, 2018, Page(s) 115300, ISSN 0165-9936
Éditeur: Elsevier BV
DOI: 10.1016/j.trac.2018.10.036

High-Throughput Metabolomics by 1D NMR

Auteurs: Alessia Vignoli, Veronica Ghini, Gaia Meoni, Cristina Licari, Panteleimon G. Takis, Leonardo Tenori, Paola Turano, Claudio Luchinat
Publié dans: Angewandte Chemie International Edition, Numéro 58/4, 2019, Page(s) 968-994, ISSN 1433-7851
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201804736

Heterogeneity of Thyroid Function and Impact of Peripheral Thyroxine Deiodination in Centenarians and Semi-Supercentenarians: Association With Functional Status and Mortality

Auteurs: Rita Ostan, Daniela Monti, Daniela Mari, Beatrice Arosio, Davide Gentilini, Evelyn Ferri, Giuseppe Passarino, Francesco De Rango, Patrizia D’Aquila, Stefano Mariotti, Renato Pasquali, Flaminia Fanelli, Laura Bucci, Claudio Franceschi, Giovanni Vitale
Publié dans: The Journals of Gerontology: Series A, Numéro 74/6, 2018, Page(s) 802-810, ISSN 1079-5006
Éditeur: Gerontological Society of America
DOI: 10.1093/gerona/gly194

First evidence of association between past environmental exposure to dioxin and DNA methylation of CYP1A1 and IGF2 genes in present day Vietnamese population

Auteurs: Cristina Giuliani, David Biggs, Thanh Tin Nguyen, Elena Marasco, Sara De Fanti, Paolo Garagnani, Minh Triet Le Phan, Viet Nhan Nguyen, Donata Luiselli, Giovanni Romeo
Publié dans: Environmental Pollution, Numéro 242, 2018, Page(s) 976-985, ISSN 0269-7491
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.envpol.2018.07.015

The epigenetics of inflammaging: The contribution of age-related heterochromatin loss and locus-specific remodelling and the modulation by environmental stimuli

Auteurs: Christine Nardini, Jean-Francois Moreau, Noémie Gensous, Francesco Ravaioli, Paolo Garagnani, Maria Giulia Bacalini
Publié dans: Seminars in Immunology, Numéro 40, 2018, Page(s) 49-60, ISSN 1044-5323
Éditeur: Academic Press
DOI: 10.1016/j.smim.2018.10.009

Genetics of Human Longevity Within an Eco-Evolutionary Nature-Nurture Framework

Auteurs: Cristina Giuliani, Paolo Garagnani, Claudio Franceschi
Publié dans: Circulation Research, Numéro 123/7, 2018, Page(s) 745-772, ISSN 0009-7330
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circresaha.118.312562

Conference proceedings (1)

Deep Graph Infomax

Auteurs: Veličković, Petar; Fedus, William; Hamilton, William L; Liò, Pietro; Bengio, Yoshua; Hjelm, R Devon
Publié dans: Numéro 2, 2019
Éditeur: University of Cambridge
DOI: 10.17863/CAM.40744