Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus: a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche

Informations projet

ELASTISLET

N° de convention de subvention: 646075

DOI

10.3030/646075

Projet clôturé

Date de signature de la CE 28 Mai 2015

Date de début 1 Juin 2015

Date de fin 31 Mai 2019

Financé au titre de

• INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials

Coût total

€ 6 214 495,00

Contribution de l’UE

€ 6 214 495,00

Coordonné par

UNIVERSIDAD DE VALLADOLID
Spain

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (4)

Quality and contingency

A quality and contingency plan is ready to be distributed

Report and management activities

A report on data mangement activities will be published

Communication and dissemination plan

A well-defined Communication and Dissemination plan, including communication objectives, messages, target audience and the tools/methods to reach the widest audience, will be defined and published. The Project image will be presented by month 6 The communication and dissemination activities carried out along the Project life, including Scientific conferences and publications, will be published by month 48

Report on existing standards and standardization landscape

A report describing the existing standards and standardization landscape will be published

Websites, patent fillings, videos etc. (1)

Project website

The Project website will be designed and ready to work

Publications

Peer reviewed articles (41)

It Takes Two to Tango: Coupling of Angiogenesis and Osteogenesis for Bone Regeneration

Auteurs: Andrea Grosso, Maximilian G. Burger, Alexander Lunger, Dirk J. Schaefer, Andrea Banfi, Nunzia Di Maggio
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 5, 2017, Page(s) 68, ISSN 2296-4185
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fbioe.2017.00068

Biomimetic click assembled multilayer coatings exhibiting responsive properties

Auteurs: Maria P. Sousa, Israel Gonzalez de Torre, Mariana B. Oliveira, José C. Rodríguez-Cabello, João F. Mano
Publié dans: Materials Today Chemistry, Numéro 4, 2017, Page(s) 150-163, ISSN 2468-5194
Éditeur: Elsevier Ltd.
DOI: 10.1016/j.mtchem.2017.04.001

Control of angiogenesis and host response by modulating the cell adhesion properties of an Elastin-Like Recombinamer-based hydrogel

Auteurs: Sebastian Manuel Staubli, Giulia Cerino, Israel Gonzalez De Torre, Matilde Alonso, Daniel Oertli, Friedrich Eckstein, Katharina Glatz, José Carlos Rodríguez Cabello, Anna Marsano
Publié dans: Biomaterials, Numéro 135, 2017, Page(s) 30-41, ISSN 0142-9612
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.biomaterials.2017.04.047

Bioactive scaffolds based on elastin-like materials for wound healing

Auteurs: J. Carlos Rodríguez-Cabello, I. González de Torre, A. Ibañez-Fonseca, M. Alonso
Publié dans: Advanced Drug Delivery Reviews, Numéro 129, 2018, Page(s) 118-133, ISSN 0169-409X
Éditeur: Elsevier BV
DOI: 10.1016/j.addr.2018.03.003

Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation

Auteurs: Boris L. Gala-Lopez, Daniel Neiman, Tatsuya Kin, Doug O’Gorman, Andrew R. Pepper, Andrew J. Malcolm, Sheina Pianzin, Peter A. Senior, Patricia Campbell, Benjamin Glaser, Yuval Dor, Ruth Shemer, A.M. James Shapiro
Publié dans: Transplantation, Numéro 102/6, 2018, Page(s) 978-985, ISSN 0041-1337
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/TP.0000000000002083

Biocompatibility of two model elastin-like recombinamer-based hydrogels formed through physical or chemical cross-linking for various applications in tissue engineering and regenerative medicine

Auteurs: Arturo Ibáñez-Fonseca, Teresa L. Ramos, Israel González de Torre, Luis Ignacio Sánchez-Abarca, Sandra Muntión, Francisco Javier Arias, María Consuelo del Cañizo, Matilde Alonso, Fermín Sánchez-Guijo, José Carlos Rodríguez-Cabello
Publié dans: Journal of Tissue Engineering and Regenerative Medicine, Numéro 12/3, 2018, Page(s) e1450-e1460, ISSN 1932-6254
Éditeur: John Wiley & Sons Ltd.
DOI: 10.1002/term.2562

Random and oriented electrospun fibers based on a multicomponent, in situ clickable elastin-like recombinamer system for dermal tissue engineering

Auteurs: Israel González de Torre, Arturo Ibáñez-Fonseca, Luis Quintanilla, Matilde Alonso, José-Carlos Rodríguez-Cabello
Publié dans: Acta Biomaterialia, Numéro 72, 2018, Page(s) 137-149, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2018.03.027

Islet Encapsulation: Physiological Possibilities and Limitations

Auteurs: Olle Korsgren
Publié dans: Diabetes, Numéro 66/7, 2017, Page(s) 1748-1754, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db17-0065

Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus

Auteurs: Per-Ola Carlsson, Daniel Espes, Amir Sedigh, Avi Rotem, Baruch Zimerman, Helena Grinberg, Tali Goldman, Uriel Barkai, Yuval Avni, Gunilla T. Westermark, Lina Carlbom, Håkan Ahlström, Olof Eriksson, Johan Olerud, Olle Korsgren
Publié dans: American Journal of Transplantation, Numéro 18/7, 2018, Page(s) 1735-1744, ISSN 1600-6135
Éditeur: Blackwell Publishing Inc.
DOI: 10.1111/ajt.14642

Glucose Effectiveness

Auteurs: Erik Korsgren, Olle Korsgren
Publié dans: Transplantation, Numéro 100/1, 2016, Page(s) 111-115, ISSN 0041-1337
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/TP.0000000000000900

Chitosan-Recombinamer Layer-by-Layer Coatings for Multifunctional Implants

Auteurs: Jeevan Govindharajulu, Xi Chen, Yuping Li, Jose Rodriguez-Cabello, Mrinal Battacharya, Conrado Aparicio
Publié dans: International Journal of Molecular Sciences, Numéro 18/2, 2017, Page(s) 369, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms18020369

Förster Resonance Energy Transfer-Paired Hydrogel Forming Silk-Elastin-Like Recombinamers by Recombinant Conjugation of Fluorescent Proteins

Auteurs: Arturo Ibáñez-Fonseca, Matilde Alonso, Francisco Javier Arias, José Carlos Rodríguez-Cabello
Publié dans: Bioconjugate Chemistry, Numéro 28/3, 2017, Page(s) 828-835, ISSN 1043-1802
Éditeur: American Chemical Society
DOI: 10.1021/acs.bioconjchem.6b00738

Intrafibrillar Mineralization of Self-Assembled Elastin-Like Recombinamer Fibrils

Auteurs: Yuping Li, Jose Carlos Rodriguez-Cabello, Conrado Aparicio
Publié dans: ACS Applied Materials & Interfaces, Numéro 9/7, 2017, Page(s) 5838-5846, ISSN 1944-8244
Éditeur: American Chemical Society
DOI: 10.1021/acsami.6b15285

Cross-linking of a biopolymer-peptide co-assembling system

Auteurs: Karla E. Inostroza-Brito, Estelle C. Collin, Anna Majkowska, Sherif Elsharkawy, Alistair Rice, Armando E. del Río Hernández, Xin Xiao, José Rodríguez-Cabello, Alvaro Mata
Publié dans: Acta Biomaterialia, Numéro 58, 2017, Page(s) 80-89, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2017.05.043

Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend

Auteurs: Esen Sayin, Rosti Hama Rashid, José Carlos Rodríguez-Cabello, Ahmed Elsheikh, Erkan Türker Baran, Vasif Hasirci
Publié dans: Bioactive Materials, Numéro 2/2, 2017, Page(s) 71-81, ISSN 2452-199X
Éditeur: Royal Society of Chemistry
DOI: 10.1016/j.bioactmat.2017.04.001

Recombinant DNA technology and click chemistry: a powerful combination for generating a hybrid elastin-like-statherin hydrogel to control calcium phosphate mineralization

Auteurs: Mohamed Hamed Misbah, Mercedes Santos, Luis Quintanilla, Christina Günter, Matilde Alonso, Andreas Taubert, José Carlos Rodríguez-Cabello
Publié dans: Beilstein Journal of Nanotechnology, Numéro 8, 2017, Page(s) 772-783, ISSN 2190-4286
Éditeur: Beilstein-Institut Zur Forderung der Chemischen Wissenschaften
DOI: 10.3762/bjnano.8.80

Regeneration of hyaline cartilage promoted by xenogeneic mesenchymal stromal cells embedded within elastin-like recombinamer-based bioactive hydrogels

Auteurs: David Pescador, Arturo Ibáñez-Fonseca, Fermín Sánchez-Guijo, Jesús G. Briñón, Francisco Javier Arias, Sandra Muntión, Cristina Hernández, Alessandra Girotti, Matilde Alonso, María Consuelo del Cañizo, José Carlos Rodríguez-Cabello, Juan Francisco Blanco
Publié dans: Journal of Materials Science: Materials in Medicine, Numéro 28/8, 2017, Page(s) 115, ISSN 0957-4530
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10856-017-5928-1

PHBV wet spun scaffold coated with ELR-REDV improves vascularization for bone tissue engineering

Auteurs: Ayse Selcen Alagoz, Jose Carlos Rodriguez-Cabello, Vasif Hasirci
Publié dans: Biomedical Materials, 2018, ISSN 1748-6041
Éditeur: Institute of Physics Publishing
DOI: 10.1088/1748-605X/aad139

Protein disorder–order interplay to guide the growth of hierarchical mineralized structures

Auteurs: Sherif Elsharkawy, Maisoon Al-Jawad, Maria F. Pantano, Esther Tejeda-Montes, Khushbu Mehta, Hasan Jamal, Shweta Agarwal, Kseniya Shuturminska, Alistair Rice, Nadezda V. Tarakina, Rory M. Wilson, Andy J. Bushby, Matilde Alonso, Jose C. Rodriguez-Cabello, Ettore Barbieri, Armando del Río Hernández, Molly M. Stevens, Nicola M. Pugno, Paul Anderson, Alvaro Mata
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-04319-0

Tuning the stiffness of surfaces by assembling genetically engineered polypeptides with tailored amino acid sequence

Auteurs: Rui R. Costa, Miguel González-Pérez, Marcos Herrero-Gutiérrez, Ricardo A. Pires, Matilde Alonso, J. Carlos Rodriguez-Cabello, Rui L. Reis, Iva Pashkuleva
Publié dans: Biomacromolecules, 2018, Page(s) 3401-3411, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.8b00723

Macroporous click-elastin-like hydrogels for tissue engineering applications

Auteurs: Alicia Fernández-Colino, Frederic Wolf, Hans Keijdener, Stephan Rütten, Thomas Schmitz-Rode, Stefan Jockenhoevel, J. Carlos Rodríguez-Cabello, Petra Mela
Publié dans: Materials Science and Engineering: C, Numéro 88, 2018, Page(s) 140-147, ISSN 0928-4931
Éditeur: Elsevier BV
DOI: 10.1016/j.msec.2018.03.013

Cartilage Regeneration in Preannealed Silk Elastin-Like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform

Auteurs: Filippo Cipriani, Melanie Krüger, Israel Gonzalez de Torre, Luis Quintanilla Sierra, Matilde Alonso Rodrigo, Linda Kock, José Carlos Rodriguez-Cabello
Publié dans: Biomacromolecules, Numéro 19/11, 2018, Page(s) 4333-4347, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.8b01211

A transferrin receptor-binding mucoadhesive elastin-like recombinamer: In vitro and in vivo characterization

Auteurs: Constancio Gonzalez-Obeso, Alessandra Girotti, J. Carlos Rodriguez-Cabello
Publié dans: Acta Biomaterialia, Numéro 88, 2019, Page(s) 241-250, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2019.02.027

Bicyclic RGD peptides with high integrin α v β 3 and α 5 β 1 affinity promote cell adhesion on elastin-like recombinamers

Auteurs: Filippo Cipriani, Dominik Bernhagen, Carmen García-Arévalo, Israel González de Torre, Peter Timmerman, José Carlos Rodríguez-Cabello
Publié dans: Biomedical Materials, Numéro 14/3, 2019, Page(s) 035009, ISSN 1748-605X
Éditeur: IOP Publishing
DOI: 10.1088/1748-605x/aafd83

Bioinspired baroplastic glycosaminoglycan sealants for soft tissues

Auteurs: Rui R. Costa, Diana Soares da Costa, Rui L. Reis, Iva Pashkuleva
Publié dans: Acta Biomaterialia, Numéro 87, 2019, Page(s) 108-117, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2019.01.040

Spatial control and cell adhesion selectivity on model gold surfaces grafted with elastin-like recombinamers

Auteurs: Tatjana Flora, I. González de Torre, Luis Quintanilla, M. Alonso, J. Carlos Rodríguez-Cabello
Publié dans: European Polymer Journal, Numéro 106, 2018, Page(s) 19-29, ISSN 0014-3057
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.eurpolymj.2018.06.026

A novel lipase-catalyzed method for preparing ELR-based bioconjugates

Auteurs: Ana M. Testera, Mercedes Santos, Alessandra Girotti, F. Javier Arias, J. Manuel Báñez, Matilde Alonso, J. Carlos Rodríguez-Cabello
Publié dans: International Journal of Biological Macromolecules, Numéro 121, 2019, Page(s) 752-759, ISSN 0141-8130
Éditeur: Elsevier BV
DOI: 10.1016/j.ijbiomac.2018.10.028

Tethering QK peptide to enhance angiogenesis in elastin-like recombinamer (ELR) hydrogels

Auteurs: Tatjana Flora, I. González de Torre, M. Alonso, J. Carlos Rodríguez-Cabello
Publié dans: Journal of Materials Science: Materials in Medicine, Numéro 30/2, 2019, ISSN 0957-4530
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10856-019-6232-z

Coating Strategies Using Layer-by-layer Deposition for Cell Encapsulation

Auteurs: Mariana B. Oliveira, Javad Hatami, João F. Mano
Publié dans: Chemistry - An Asian Journal, Numéro 11/12, 2016, Page(s) 1753-1764, ISSN 1861-4728
Éditeur: Wiley - V C H Verlag GmbbH & Co.
DOI: 10.1002/asia.201600145

Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein–peptide system

Auteurs: Karla E. Inostroza-Brito, Estelle Collin, Orit Siton-Mendelson, Katherine H. Smith, Amàlia Monge-Marcet, Daniela S. Ferreira, Raúl Pérez Rodríguez, Matilde Alonso, José Carlos Rodríguez-Cabello, Rui L. Reis, Francesc Sagués, Lorenzo Botto, Ronit Bitton, Helena S. Azevedo, Alvaro Mata
Publié dans: Nature Chemistry, Numéro 7/11, 2015, Page(s) 897-904, ISSN 1755-4330
Éditeur: Nature Publishing Group
DOI: 10.1038/nchem.2349

Multilayered Films Produced by Layer-by-Layer Assembly of Chitosan and Alginate as a Potential Platform for the Formation of Human Adipose-Derived Stem Cell aggregates

Auteurs: Javad Hatami, Sandra Silva, Mariana Oliveira, Rui Costa, Rui Reis, João Mano
Publié dans: Polymers, Numéro 9/12, 2017, Page(s) 440, ISSN 2073-4360
Éditeur: MPDI Open Access Publishing
DOI: 10.3390/polym9090440

3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine

Auteurs: Mercedes Vila, Ana García, Alessandra Girotti, Matilde Alonso, Jose Carlos Rodríguez-Cabello, Arlyng González-Vázquez, Josep A. Planell, Elisabeth Engel, Julia Buján, Natalio García-Honduvilla, María Vallet-Regí
Publié dans: Acta Biomaterialia, Numéro 45, 2016, Page(s) 349-356, ISSN 1742-7061
Éditeur: Elsevier BV
DOI: 10.1016/j.actbio.2016.09.016

Genetically Engineered Elastin-based Biomaterials for Biomedical Applications

Auteurs: Mercedes Santos, Sofia Serrano-Ducar, Juan Gonzalez-Valdivieso, Reinaldo Vallejo, Alessandra Girotti, Purificacion Cuadrado, Francisco Javier Arias
Publié dans: Current Medicinal Chemistry, Numéro 25, 2018, Page(s) 1-28, ISSN 0929-8673
Éditeur: Bentham Science Publishers
DOI: 10.2174/0929867325666180508094637

Non-invasive detection of human cardiomyocyte death using methylation patterns of circulating DNA

Auteurs: Hai Zemmour, David Planer, Judith Magenheim, Joshua Moss, Daniel Neiman, Dan Gilon, Amit Korach, Benjamin Glaser, Ruth Shemer, Giora Landesberg, Yuval Dor
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-03961-y

Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease

Auteurs: Joshua Moss, Judith Magenheim, Daniel Neiman, Hai Zemmour, Netanel Loyfer, Amit Korach, Yaacov Samet, Myriam Maoz, Henrik Druid, Peter Arner, Keng-Yeh Fu, Endre Kiss, Kirsty L. Spalding, Giora Landesberg, Aviad Zick, Albert Grinshpun, A. M. James Shapiro, Markus Grompe, Avigail Dreazan Wittenberg, Benjamin Glaser, Ruth Shemer, Tommy Kaplan, Yuval Dor
Publié dans: Nature Communications, Numéro 9/1, 2018, Page(s) 1-12, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-07466-6

Self-assembly in Elastin-Like Recombinamers: a Mechanism to Mimic Natural Complexity

Auteurs: Luis Quintanilla-Sierra, Carmen García-Arévalo, J.C. Rodriguez-Cabello
Publié dans: Materials Today Bio, 2019, Page(s) 100007, ISSN 2590-0064
Éditeur: Elsevier
DOI: 10.1016/j.mtbio.2019.100007

Monitoring liver damage using hepatocyte-specific methylation markers in cell-free circulating DNA

Auteurs: Roni Lehmann-Werman, Judith Magenheim, Joshua Moss, Daniel Neiman, Ofri Abraham, Sheina Piyanzin, Hai Zemmour, Ilana Fox, Talya Dor, Markus Grompe, Giora Landesberg, Bao-Li Loza, Abraham Shaked, Kim Olthoff, Benjamin Glaser, Ruth Shemer, Yuval Dor
Publié dans: JCI Insight, Numéro 3/12, 2018, ISSN 2379-3708
Éditeur: JCI Insight
DOI: 10.1172/jci.insight.120687

Hydrophobic Cholesteryl Moieties Trigger Substrate Cell–Membrane Interaction of Elastin–Mimetic Protein Coatings in Vitro

Auteurs: Leander Poocza, Filippo Cipriani, Matilde Alonso, José Carlos Rodríguez-Cabello
Publié dans: ACS Omega, Numéro 4/6, 2019, Page(s) 10818-10827, ISSN 2470-1343
Éditeur: ACS Publications
DOI: 10.1021/acsomega.9b00548

Use of proteolytic sequences with different cleavage kinetics as a way to generate hydrogels with preprogrammed cell-infiltration patterns imparted over their given 3D spatial structure

Auteurs: Tatjana Flora, I González de Torre, M Alonso, J Carlos Rodríguez-Cabello
Publié dans: Biofabrication, Numéro 11/3, 2019, Page(s) 035008, ISSN 1758-5090
Éditeur: IOP Publishing
DOI: 10.1088/1758-5090/ab10a5

Self-Assembling ELR-Based Nanoparticles as Smart Drug-Delivery Systems Modulating Cellular Growth via Akt

Auteurs: Juan Gonzalez-Valdivieso, Alessandra Girotti, Raquel Muñoz, J. Carlos Rodriguez-Cabello, F. Javier Arias
Publié dans: Biomacromolecules, Numéro 20/5, 2019, Page(s) 1996-2007, ISSN 1525-7797
Éditeur: American Chemical Society
DOI: 10.1021/acs.biomac.9b00206

Silk-ELR co-recombinamer covered stents obtained by electrospinning

Auteurs: M Putzu, F Causa, Manuel Parente, Israel González de Torre, J C Rodriguez-Cabello, P A Netti
Publié dans: Regenerative Biomaterials, Numéro 6/1, 2018, Page(s) 21-28, ISSN 2056-3418
Éditeur: ACS Publications
DOI: 10.1093/rb/rby022