Livrables Documents, reports (3) Outline of the information recorded in a “PDX Passport” This Deliverable relates to Task 2.2.1. All PDX models biobanked for the performance of WP3 and WP4 will be accompanied by a PDX Passport. This information sheet will summarise all relevant information on health status (WP2), as well as ethics (WP5) and minimal information on the model defined under WP1. An outline of the Passport will be drafted at the consensus meeting in M1-M2 and further optimised along the first 6 months of the project. This report will therefore outline the information agreed to be recorded in the PDX Passport. Summary of the outcome of the two ethics workshops This deliverable is related to Task 52 and will describe the discussions and outcome of the two ethics workshops organised at M18 and M36 of the project on the side of our GA meetings Flyer describing the EurOPDX Infrastructure and available resources and services This deliverable relates to Task 7.1.4. A flyer will be designed to include crucial information about the project, the partners involved, the services provided. Its content will remain general, in order to remain valid during the whole project duration, and provide all useful links to allow users to follow our activities through the website, Data Portal, and our Twitter account and LinkedIn group. The flyer will be available at M20, and its design and content described in this deliverable. Publications Peer reviewed articles (13) The EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization Auteurs: Zdenka Dudová; Nathalie Conte; Jeremy Mason; Dalibor Stuchlík; Radim Peša; Csaba Halmagyi; Zinaida Perova; Abayomi Mosaku; Ross Thorne; Alex Follette; Ľuboslav Pivarč; Radim Šašinka; Muhammad Usman; Steven Neuhauser; Dale A. Begley; Debra M. Krupke; Massimiliano Frassà; Alessandro Fiori; Riccardo Corsi; Luca Vezzadini; Claudio Isella; Andrea Bertotti; Carol Bult; Helen Parkinson; Enzo Medi Publié dans: BMC Genomics, Numéro 14712164, 2022, ISSN 1471-2164 Éditeur: BioMed Central DOI: 10.1186/s12864-022-08367-1 Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models Auteurs: Alice C O'Farrell 1 , Monika A Jarzabek 1 , Andreas U Lindner 2 , Steven Carberry 2 , Emer Conroy 3 , Ian S Miller 1 , Kate Connor 1 , Liam Shiels 1 , Eugenia R Zanella 4 5 , Federico Lucantoni 2 , Adam Lafferty 1 , Kieron White 1 , Mariangela Meyer Meyer Villamandos 2 , Patrick Dicker 6 , William M Gallagher 3 , Simon A Keek 7 , Sebastian Sanduleanu 7 , Philippe Lambin 7 8 , Publié dans: Cancers, Numéro 2020, 2020, ISSN 2072-6694 Éditeur: Multidisciplinary Digital Publishing Institute (MDPI) DOI: 10.3390/cancers12102978 Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects. Auteurs: Ian S. Miller; Sonja Khan; Liam P. Shiels; Sudipto Das; Alice C. O' Farrell; Kate Connor; Adam Lafferty; Bruce Moran; Claudio Isella; Paul Loadman; Emer Conroy; Susan Cohrs; Roger Schibli; Robert S. Kerbel; William M. Gallagher; Elisabetta Marangoni; Kathleen Bennett; Darran P. O' Connor; Róisín M. Dwyer; Annette T. Byrne Publié dans: Cancer Medicine, 2022, ISSN 2045-7634 Éditeur: John Wiley and Sons Ltd DOI: 10.1002/cam4.4756 Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts Auteurs: Xing Yi Woo, Jessica Giordano, Anuj Srivastava, Zi-Ming Zhao, Michael W. Lloyd, Roebi de Bruijn, Yun-Suhk Suh, Rajesh Patidar, Li Chen, Sandra Scherer, Matthew H. Bailey, Chieh-Hsiang Yang, Emilio Cortes-Sanchez, Yuanxin Xi, Jing Wang, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Vito W. Rebecca, Hua Sun, R. Jay Mashl, Sherri R. Davies, Ryan Jeon, Christian Frech, Jelena Randjelovic, Jacqueline Publié dans: Nature Genetics, Numéro 53/1, 2021, Page(s) 86-99, ISSN 1061-4036 Éditeur: Nature Publishing Group DOI: 10.1038/s41588-020-00750-6 EGFR Blockade Reverts Resistance to KRAS G12C Inhibition in Colorectal Cancer Auteurs: Vito Amodio, Rona Yaeger, Pamela Arcella, Carlotta Cancelliere, Simona Lamba, Annalisa Lorenzato, Sabrina Arena, Monica Montone, Benedetta Mussolin, Yu Bian, Adele Whaley, Marika Pinnelli, Yonina R. Murciano-Goroff, Efsevia Vakiani, Nicola Valeri, Wei-Li Liao, Anuja Bhalkikar, Sheeno Thyparambil, Hui-Yong Zhao, Elisa de Stanchina, Silvia Marsoni, Salvatore Siena, Andrea Bertotti, Livio Trusolino, Publié dans: Cancer Discovery, Numéro 10/8, 2020, Page(s) 1129-1139, ISSN 2159-8274 Éditeur: American Association for Cancer Research Inc. DOI: 10.1158/2159-8290.cd-20-0187 Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research Auteurs: Andrea Mignone, Alberto Grand, Alessandro Fiori, Enzo Medico, Andrea Bertotti Publié dans: Database, Numéro 2019, 2019, ISSN 1758-0463 Éditeur: Oxford University Press DOI: 10.1093/database/baz080 A comprehensive PDX gastric cancer collection captures cancer cell intrinsic transcriptional MSI traits. Auteurs: Simona Corso, Claudio Isella, Sara E Bellomo, Maria Apicella, Stefania Durando, Cristina Migliore, Stefano Ughetto, Laura D'Errico, Silvia Menegon, Daniel Moya-Rull, Marilisa Cargnelutti, Tania Capeloa, Daniela Conticelli, Jessica Giordano, Tiziana Venesio, Antonella Balsamo, Caterina Marchiò, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli Romario, Stefano de Pascale, Giovanni Sgroi, Emanu Publié dans: Cancer Research, 2019, Page(s) canres.1166.2019, ISSN 0008-5472 Éditeur: American Association for Cancer Research DOI: 10.1158/0008-5472.can-19-1166 Patient-derived xenografts (PDXs) as model systems for human cancer Auteurs: Federica Invrea, Roberta Rovito, Erica Torchiaro, Consalvo Petti, Claudio Isella, Enzo Medico Publié dans: Current Opinion in Biotechnology, Numéro 63, 2020, Page(s) 151-156, ISSN 0958-1669 Éditeur: Elsevier BV DOI: 10.1016/j.copbio.2020.01.003 Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling Auteurs: Rachel Eyre, Denis G. Alférez, Angélica Santiago-Gómez, Kath Spence, James C. McConnell, Claire Hart, Bruno M. Simões, Diane Lefley, Claudia Tulotta, Joanna Storer, Austin Gurney, Noel Clarke, Mick Brown, Sacha J. Howell, Andrew H. Sims, Gillian Farnie, Penelope D. Ottewell, Robert B. Clarke Publié dans: Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723 Éditeur: Nature Publishing Group DOI: 10.1038/s41467-019-12807-0 Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype Auteurs: Barbara Lupo, Francesco Sassi, Marika Pinnelli, Francesco Galimi, Eugenia R. Zanella, Valentina Vurchio, Giorgia Migliardi, Paolo Armando Gagliardi, Alberto Puliafito, Daria Manganaro, Paolo Luraghi, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Carla Boccaccio, Enzo Medico, Luca Primo, Daniel Nichol, Inmaculada Spiteri, Timon Heide, Alexandra Vatsiou, Trevor A. Graham, Elena Élez, Guillem Ar Publié dans: Science Translational Medicine, Numéro 12/555, 2020, Page(s) eaax8313, ISSN 1946-6234 Éditeur: American Association for the Advancement of Science DOI: 10.1126/scitranslmed.aax8313 One tool to find them all: a case of data integration and querying in a distributed LIMS platform Auteurs: Alberto Grand, Emanuele Geda, Andrea Mignone, Andrea Bertotti, Alessandro Fiori Publié dans: Database, Numéro 2019, 2019, ISSN 1758-0463 Éditeur: Oxford University Press DOI: 10.1093/database/baz004 Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts Auteurs: Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alférez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell Publié dans: Breast Cancer Research, Numéro 21/1, 2019, ISSN 1465-542X Éditeur: Springer Nature DOI: 10.1186/s13058-019-1220-2 Melanoma models for the next generation of therapies Auteurs: E. Elizabeth Patton, Kristen L. Mueller, David J. Adams, Niroshana Anandasabapathy, Andrew E. Aplin, Corine Bertolotto, Marcus Bosenberg, Craig J. Ceol, Ping Chi, Meenhard Herlyn, Sheri L. Holmen, Florian A. Karreth, Charles K. Kaufman, Shaheen Khan, Sebastian Kobold, Eleonora Leucci, Carmit Levy, David B. Lombard, Amanda W. Lund, Kerrie L. Marie, Jean-Christophe Marine, Richard Marais, Martin McM Publié dans: Cancer Cell, 2021, ISSN 1535-6108 Éditeur: Cell Press DOI: 10.1016/j.ccell.2021.01.011 Other (2) EurOPDX IT tools to support cancer research with patient-derived xenograft models Auteurs: Enzo Medico, Emilie Vinolo Publié dans: Webinar, 2020 Éditeur: EMBL-EBI DOI: 10.6019/tol.europdxtools-w.2020.00001.1 EurOPDX Data Portal: a repository of patient-derived xenograft models Auteurs: Enzo Medico, Emilie Vinolo Publié dans: Webinar, 2019 Éditeur: EMBL-EBI DOI: 10.6019/tol.europdx-w.2019.00001.1 Conference proceedings (3) The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models Auteurs: E. Medico, M.Bentires-Alj, A. V. Biankin, A. Bruna, A. T. Byrne, C. Caldas, R. B. Clarke, G. Coukos, O. Elemento, M. Hidalgo, G. Inghirami, S. de Jong, J. Jonkers, A. Krenek, E. Leucci, G. M. Maelandsmo, M. Th. Mayrhofer, T. F. Meehan, S. P. Niclou, P. G. Pelicci, A. Piris-Gimenez, L. Price, S. Roman-Roman, L. Trusolino, L. Vezzadini, A. Villanueva, E. Vinolo. Publié dans: AACR Annual Meeting 2018 Online Proceedings, 2018 Éditeur: American Association for Cancer Research The EurOPDX EDIReX project: towards a European Research Infrastructure on patient-derived cancer models Auteurs: E. Vinolo1, J.P. Morris1, A. Bruna2, A.T. Byrne3, R.B. Clarke4, S. de Jong5, J. Jonkers6, A. Krenek7, G.M. Maelandsmo8, M.T. Mayrhofer9, T.F. Meehan10, P.G. Pelicci11, A. Piris-Gimenez12, L. Price13, L. Rizzotto14, S. Roman-Roman15, F. Sarno16, L. Vezzadini17, A. Villanueva18, E. Medico19. 1Seeding Science SPRL, Limelette, Belgium; 2Cancer Research UK Cambridge Institute, Cambridge Cancer Centre Publié dans: European Journal of Cancer, Numéro Volume 103S1, November 2018, 2018, Page(s) 118, ISSN 0959-8049 Éditeur: Elsevier Patient-derived 3D tumor cultures for compound screening and pre-clinical drug development Auteurs: Sander Basten, Bram Herpers, Kuan Yan, Julia Schueler, Leo S. Price Publié dans: AACR Annual Meeting 2019 Online Proceedings, 2019 Éditeur: American Association for Cancer Research Recherche de données OpenAIRE... Une erreur s’est produite lors de la recherche de données OpenAIRE Aucun résultat disponible
