Study of the role of m6A RNA methylation in the nervous system of Drosophila melanogaster: an in-vivo model to dissect the impact of epitranscriptome reprogramming in physiology and cancer

Informations projet

EpiMethFly

N° de convention de subvention: 752621

DOI 10.3030/752621

Projet clôturé

Date de signature de la CE 22 Février 2017

Date de début 19 Septembre 2017

Date de fin 18 Avril 2020

Financé au titre de

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coût total € 180 277,20

Contribution de l’UE € 180 277,20

Coordonné par

UNIVERSITA DEGLI STUDI DI TRENTO
Italie

Objectif

The identification of reversible m6A RNA modification strongly points towards the existence of a novel level of complexity of gene expression regulation. Recent studies have suggested that m6A might be involved in several biological processes and that dysregulation of this modification may contributes to neuro-developmental abnormalities and cancer. The aim of the described research is to clarify the role of m6A RNA modification in the nervous system in physiological conditions -during brain development - and to discover its contribution to pathological conditions - Glioblastoma. To achieve this goal I propose to use Drosophila melanogaster to study : Aim 1 the impact of perturbing different members of the m6A machinery on brain morphology, progenitors differentiation and neuronal axon growth and guidance; Aim2 the impact of modulating the levels of m6A RNA modification in a Glioblastoma model and study the effect of this perturbation on tumor growth and progression. The results obtained will be of fundamental importance for the development of the field of epitranscriptomics by shedding light on the biological outcome of m6A modification in-vivo. In particular, Drosophila might become an efficient model to screen for novel members of the m6A machinery and to clarify how m6A is read and translated into a biological response. Finally, the data obtained by the analysis of the Glioblastoma model, will strongly contribute to the understanding of the link between RNA methylation and tumor development and aggressiveness.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.

• sciences naturelles › sciences biologiques › neurobiologie
• sciences médicales et de la santé › médecine clinique › oncologie
• sciences médicales et de la santé › médecine fondamentale › physiologie
• sciences naturelles › sciences biologiques › génétique › ARN

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Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Thème(s)

• MSCA-IF-2016 - Individual Fellowships

Appel à propositions

H2020-MSCA-IF-2016

Régime de financement

MSCA-IF-EF-ST -

Coordinateur

UNIVERSITA DEGLI STUDI DI TRENTO

• Contribution nette de l'UE: € 180 277,20
• Adresse: VIA CALEPINA 14 ; 38122 Trento ; Italie
• Région: Nord-Est › Provincia Autonoma di Trento › Trento
• Type d’activité: Établissements d’enseignement supérieur ou secondaire
• Coût total: € 180 277,20