Direct cell reprogramming therapy in myocardial regeneration through an engineered multifunctional platform integrating biochemical instructive cues

Informations projet

BIORECAR

N° de convention de subvention: 772168

DOI

10.3030/772168

Projet clôturé

Date de signature de la CE 15 Juin 2018

Date de début 1 Juillet 2018

Date de fin 28 Février 2025

Financé au titre de

• EXCELLENT SCIENCE - European Research Council (ERC)

Coût total

€ 2 000 000,00

Contribution de l’UE

€ 2 000 000,00

Coordonné par

POLITECNICO DI TORINO
Italy

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Publications

Conference proceedings (20)

Design of bioartificial scaffolds as in vitro models of pathological human cardiac tissue

Auteurs: Irene Carmagnola, Alice Zoso, Mattia Spedicati, Gerardina Ruocco, Valeria Chiono
Publié dans: 5th Healthcare & Life Science & Entrepreneurship workshop, 2020, Page(s) 1
Éditeur: Vision Dynamics Science & Entrepreneurship

Novel lipoplexes for efficient microRNA delivery to human cardiac fibroblasts

Auteurs: Nicoletti, Letizia; Tarricone, Giulia; Paoletti, Camilla; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Mattu, Clara; Chiono, Valeria
Publié dans: Vancouver Nanomedicine Day, 17 Sept. 2020 - Abstract Booklet, 2020
Éditeur: Nanomedicine Innovation Network

In vitro models of human cardiac fibrotic tissue based on bioartificial scaffolds

Auteurs: Ireme Carmagnola; Alice ZOSO; Valeria Chiono
Publié dans: Linz 2019 22nd European Congress on Alternatives to Animal Testing - Eusaat 2019 - 19th Annual Congress of EUSAAT - ALTEX PROCEEDINGS, 2019
Éditeur: Springer Spektrum

MICRORNA-RELEASING LIPOPLEXES FOR DIRECT CARDIAC REPROGRAMMING IN PATHOLOGICAL CARDIAC TISSUE

Auteurs: Letizia Nicoletti; CAMILLA PAOLETTI; Tarricone, Giulia; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Clara Mattu; Valeria Chiono
Publié dans: "Abstract of the conference ""Nature Conferences - RNA at the Bench and Bedside II"", 11-13 November 2020", 2020
Éditeur: Politecnico di Torino - IRIS

Tissue-engineered models of human pathological cardiac tissue through bioartificial scaffolds

Auteurs: Ireme Carmagnola; Alice ZOSO; Spedicati, Mattia; Ruocco, Gerardina; Valeria Chiono
Publié dans: "Abstract of the ""11TH World Biomaterials Congress"", online, 11 - 15 Dec. 2020", 2020
Éditeur: Politecnico di Torino - IRIS

“Bioartificial” scaffolds for the development of in vitro models of human cardiac fibrotic tissue

Auteurs: Ireme Carmagnola; Alice ZOSO; Valeria Chiono
Publié dans: Abstract of the 30th Annual Conference of the European Society for Biomaterials (ESB), Dresden (Germany), Sept. 9-13, 2019; Dresden (DE)., 2019
Éditeur: PORTO-IRIS

Direct reprogramming of human cardiac fibroblasts into cardiomyocytes in 2D and 3D culture microenvironments

Auteurs: Paoletti Camilla, Divieto Carla, Chiono, Valeria
Publié dans: Joint Meeting of the ESC Working Groups on Myocardial Function and Cellular Biology of the Heart, 9-11 May 2019, Naples (Italy), 2019
Éditeur: PORTO-Iris

Biomimetic scaffolds and multifunctional materials in the regeneration of pathological cardiac tissue

Auteurs: Irene Carmagnola, Alice Zoso, Camilla Paoletti, Giulia Tarricone, Mattia Spedicati, Gerardina Ruocco, Franca di Meglio, Daria Nurzynska, Carla Divieto, Valeria Chiono
Publié dans: Abstract of NICE – 2020 International Conference, 2020
Éditeur: NICE – 2020 International Conference

MicroRNA releasing lipoplexes as potential nanosystems against COVID 19

Auteurs: Letizia Nicoletti; CAMILLA PAOLETTI; Tarricone, Giulia; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Clara Mattu; Valeria Chiono
Publié dans: Virtual FISV Symposium on SARS CoV 2 Biology and COVID 19: Current research and perspectives Programme and Abstracts September 16, 2020, 2020
Éditeur: Federazione Italiana Scienze della Vita

Direct reprogramming of human cardiac fibroblasts towards the cardiac phenotype through non-viral approaches.

Auteurs: Camilla Paoletti, Letizia Nicoletti, Giulia Tarricone, Carla Divieto3 Franca Di Meglio, Daria Nurzynska, Clara Mattu, Ilaria Andreana, Silvia Arpicco, Barbara Stella, Valeria Chiono
Publié dans: 5th Healthcare & Life Science & Entrepreneurship workshop, 2020, Page(s) 1
Éditeur: Vision Dynamics Science and Entrepreneurship

Direct reprogramming of human fibroblasts as a novel tool in cardiac tissue engineering

Auteurs: Valeria Chiono
Publié dans: TERMIS EU2019 Conference Book, 2019, Page(s) 813
Éditeur: Termis

Direct reprogramming of human cardiac fibroblasts to cardiomyocytes using microRNA mimics

Auteurs: Camilla Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Publié dans: Termis EU 2019 Conference Book, 2019, Page(s) 1442
Éditeur: Termis

Direct cell reprogramming as a new emerging strategy in cardiac regeneration

Auteurs: Chiono, Valeria; Paoletti, Camilla; Carla, Divieto; Franca Di Meglio,; Clotilde, Castaldo; Daria, Nurzynska
Publié dans: Termis WC 2018 programme, 2018, Page(s) 14
Éditeur: Termis

Lipoplexes for miRNA delivery in myocardial regeneration

Auteurs: Nicoletti, Letizia; Tarricone, Giulia; Paoletti, Camilla; Carla, Divieto; Ilaria, Andreana; Barbara, Stella; Silvia, Arpicco; Mattu, Clara; Chiono, Valeria
Publié dans: Nano Day IV Program and Book of Abstracts (Nano Day IV; Milan, 11-14 Dec. 2020), 2019, Page(s) 136
Éditeur: University of Parma and Cinsa

In vitro models of human cardiac fibrotic tissue based on bioartificial scaffolds

Auteurs: Carmagnola, Irene; Zoso, Alice; Chiono, Valeria
Publié dans: ALTEX Proceeding, 2019, Page(s) 29, ISSN 2194-0479
Éditeur: Spinger Spektrum

Thermosensitive bioartificial hydrogels as smart injectable and biocompatible systems allowing post-injection chemical crosslinking

Auteurs: Chiono, Valeria; Laurano, Rossella; Zoso, Alice; Boffito, Monica
Publié dans: European Society for Biomaterials (ESB) programme, 2019, Page(s) "#943"
Éditeur: ESB

Direct reprogramming of human cardiac fibroblasts to cardiomyocytes using microRNA mimics

Auteurs: Camilla, Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Publié dans: JRC Summer School 2019: Non-Animal Aprroaches in Science. Challenges & Future Directions; 21-24 May 2019, Ispra (IT), 2019, Page(s) 74
Éditeur: JRC

INFLUENCE OF 3D CULTURE MICROENVIRONMENT ON MICRORNA-MEDIATED DIRECT REPROGRAMMING OF HUMAN CARDIAC FIBROBLASTS INTO CARDIOMYOCYTES

Auteurs: Camilla Paoletti, Carla Divieto, Franca Di Meglio, Daria Nurzynska, Valeria Chiono
Publié dans: Advanced Cell Therapies and Tissue Engineering, 2019, Page(s) 32
Éditeur: Ospedale San Raffaele and Nature

IN VITRO MODELS OF HUMAN PATHOLOGICAL CARDIAC TISSUE VIA BIOARTIFICIAL SCAFFOLDS

Auteurs: Valeria Chiono, Alice Zoso, Mattia Spedicati, Gerardina Ruocco, Irene Carmagnola
Publié dans: Advanced Cell Therapies and Tissue Engineering, 2019, Page(s) 28
Éditeur: Ospedale San Raffaele and Nature

In vitro models of fibrotic cardiac tissue as a potential tool for testing cardioprotective therapies for cardiovascular diseases related to COVID-19

Auteurs: Mattia Spedicati, Gerardina Ruocco, Alice Zoso, Irene Carmagnola, Valeria Chiono
Publié dans: Virtual FISV Symposium on SARS-CoV-2 Biology and COVID-19: Current research and perspectives, 2020, ISBN 978-88-943891-2-8
Éditeur: FISV - Federazione Italiana Scienze della Vita

Peer reviewed articles (25)

Using Poloxamer® 407 as Building Block of Amphiphilic Poly(ether urethane)s: Effect of its Molecular Weight Distribution on Thermo-Sensitive Hydrogel Performances in the Perspective of Their Biomedical Application

Auteurs: Rossella Laurano, Michela Abrami, Mario Grassi, Gianluca Ciardelli, Monica Boffito, Valeria Chiono
Publié dans: Frontiers in Materials, Numéro 7, 2020, ISSN 2296-8016
Éditeur: Frontiers
DOI: 10.3389/fmats.2020.594515

Human Cardiac Progenitor Cell-Derived Extracellular Vesicles Exhibit Promising Potential for Supporting Cardiac Repair in Vitro

Auteurs: Veronica Romano; Immacolata Belviso; Anna Maria Sacco; Domenico Cozzolino; Daria Nurzynska; Cristiano Amarelli; Ciro Maiello; Felice Sirico; Franca Di Meglio; Clotilde Castaldo
Publié dans: Front Physiol, 2022, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.879046

The Broad Spectrum of LMNA Cardiac Diseases: From Molecular Mechanisms to Clinical Phenotype

Auteurs: Silvia Crasto, Ilaria My, Elisa Di Pasquale
Publié dans: Frontiers in Physiology, Numéro 11, 2020, ISSN 1664-042X
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fphys.2020.00761

MicroRNA-Mediated Direct Reprogramming of Human Adult Fibroblasts Toward Cardiac Phenotype

Auteurs: C. Paoletti, C. Divieto, G. Tarricone, F. Di Meglio, D. Nurzynska, V. Chiono
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 8, 2020, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2020.00529

In Vitro Mechanical Stimulation to Reproduce the Pathological Hallmarks of Human Cardiac Fibrosis on a Beating Chip and Predict The Efficacy of Drugs and Advanced Therapies

Auteurs: Roberta Visone; Camilla Paoletti; Alessandro Cordiale; Letizia Nicoletti; Carla Divieto; Marco Rasponi; Valeria Chiono; Paola Occhetta
Publié dans: Adv Healthc Mater, 2024, ISSN 2192-2659
Éditeur: World Scientific
DOI: 10.1002/adhm.202301481

Editorial: Advanced Therapies for Cardiac Regeneration

Auteurs: Monica Boffito, Susanna Sartori, Ipsita Roy, Irene Carmagnola, Valeria Chiono
Publié dans: Frontiers in Bioengineering and Biotechnology, 2021, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2021.644076

Internally-crosslinked alginate dialdehyde/alginate/gelatin-based hydrogels as bioprinting inks for prospective cardiac tissue engineering applications

Auteurs: Giovanni Paolo Stola, Camilla Paoletti, Letizia Nicoletti, Geo Paul, Claudio Cassino, Leonardo Marchese, Valeria Chiono, Elena Marcello
Publié dans: International Journal of Bioprinting, 2024, Page(s) 4014, ISSN 2424-7723
Éditeur: AccScience Publishing
DOI: 10.36922/ijb.4014

Design of Injectable Bioartificial Hydrogels by Green Chemistry for Mini-Invasive Applications in the Biomedical or Aesthetic Medicine Fields

Auteurs: Rossella Laurano; Monica Boffito; Claudio Cassino; Francesco Liberti; Gianluca Ciardelli; Valeria Chiono
Publié dans: Gels; Volume 9; Numéro 1; Pages: 59, 2023, ISSN 2310-2861
Éditeur: MDPI
DOI: 10.3390/gels9010059

Cardiac Tissue-like 3D Microenvironment Enhances Route towards Human Fibroblast Direct Reprogramming into Induced Cardiomyocytes by microRNAs

Auteurs: Camilla Paoletti; Elena Marcello; Maria Luna Melis; Carla Divieto; Daria Nurzynska; Valeria Chiono
Publié dans: Cells; Volume 11; Numéro 5; Pages: 800, Numéro 17, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11050800

Lipoplexes for effective in vitro delivery of microRNAs to adult human cardiac fibroblasts for perspective direct cardiac cell reprogramming

Auteurs: Letizia Nicoletti; Camilla Paoletti; Giulia Tarricone; Ilaria Andreana; Barbara Stella; Silvia Arpicco; Carla Divieto; Clara Mattu; Valeria Chiono
Publié dans: Nanomedicine . 2022 Sep;45:102589. doi: 10.1016/j.nano.2022.102589. Epub 2022 Jul 28, Numéro 20, 2022, ISSN 1549-9634
Éditeur: Elsevier BV
DOI: 10.1016/j.nano.2022.102589

Zein as a renewable material for the preparation of green nanoparticles for drug delivery

Auteurs: Tivano, Francesca; Chiono, Valeria
Publié dans: Frontiers in Biomaterials Science, 2023, ISSN 2813-3749
Éditeur: Frontiers
DOI: 10.3389/fbiom.2023.1156403

Impact of Biomaterials on Differentiation and Reprogramming Approaches for the Generation of Functional Cardiomyocytes

Auteurs: Camilla Paoletti, Carla Divieto, Valeria Chiono
Publié dans: Cells, Numéro 7/9, 2018, Page(s) 114, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells7090114

MicroRNA delivery through nanoparticles

Auteurs: Sharon Wei Ling Lee, Camilla Paoletti, Marco Campisi, Tatsuya Osaki, Giulia Adriani, Roger D. Kamm, Clara Mattu, Valeria Chiono
Publié dans: Journal of Controlled Release, Numéro 313, 2019, Page(s) 80-95, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2019.10.007

In vitro models of human cardiac fibrotic tissue on ‘bioartificial’ scaffolds

Auteurs: Alice Zoso, Irene Carmagnola, Gerardina Ruocco, Mattia Spedicati, Valeria Chiono
Publié dans: Biomedical Science and Engineering, 2020, Page(s) 1, ISSN 2531-9892
Éditeur: Page Press
DOI: 10.4081/bse.2019.122

iPS, organoids and 3D models as advanced tools for in vitro toxicology

Auteurs: Nathalie Steimberg
Publié dans: ALTEX, 2020, Page(s) 136-140, ISSN 1868-596X
Éditeur: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.14573/altex.1911071

Toward Cardiac Regeneration: Combination of Pluripotent Stem Cell-Based Therapies and Bioengineering Strategies

Auteurs: Marta Mazzola, Elisa Di Pasquale
Publié dans: Frontiers in Bioengineering and Biotechnology, Numéro 8, 2020, Page(s) 23, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2020.00455

Biomimetic design of bioartificial scaffolds for the in vitro modelling of human cardiac fibrosis

Auteurs: Mattia Spedicati, Gerardina Ruocco, Alice Zoso, Leonardo Mortati, Andrea Lapini, Andrea Delledonne, Carla Divieto, Veronica Romano, Clotilde Castaldo, Franca Di Meglio, Daria Nurzynska, Irene Carmagnola, Valeria Chiono
Publié dans: Front. Bioeng. Biotechnol., 2022, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2022.983872

Biomaterials-Enhanced Intranasal Delivery of Drugs as a Direct Route for Brain Targeting

Auteurs: Elena Marcello; Valeria Chiono
Publié dans: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043390

Electroconductive Photo-Curable PEGDA-Gelatin/PEDOT:PSS Hydrogels for Prospective Cardiac Tissue Engineering Application

Auteurs: Daniele Testore, Alice Zoso, Galder Kortaberria, Marco Sangermano, Valeria Chiono
Publié dans: Front. Bioeng. Biotechnol., 24 June 2022 Sec. Biomaterials, Volume 10 - 2022, Numéro 10, 2022, ISSN 2296-4185
Éditeur: Frontiers
DOI: 10.3389/fbioe.2022.897575

Alginate dialdehyde-gelatin bioinks exploiting internal gelation mechanism for cardiac tissue engineering

Auteurs: E. Marcello, G. P. Stola, C. Paoletti, L. Nicoletti, V. Chiono
Publié dans: Biomedical Science and Engineering, Numéro 4, 2023, ISSN 2531-9892
Éditeur: PAGEPress Publications
DOI: 10.4081/bse.212

3D bioartificial stretchable scaffolds mimicking the mechanical hallmarks of human cardiac fibrotic tissue

Auteurs: Mattia Spedicati, Francesca Tivano, Alice Zoso, Janira Bei, Mario Lavella, Irene Carmagnola, Valeria Chiono
Publié dans: International Journal of Bioprinting, 2024, Page(s) 2247, ISSN 2424-7723
Éditeur: AccScience Publishing
DOI: 10.36922/ijb.2247

Biomimetic Electrospun Scaffold-Based In Vitro Model Resembling the Hallmarks of Human Myocardial Fibrotic Tissue

Auteurs: Gerardina Ruocco; Alice Zoso; Leonardo Mortati; Irene Carmagnola; Valeria Chiono
Publié dans: ACS Biomater. Sci. Eng., 2023, ISSN 2373-9878
Éditeur: ACS
DOI: 10.1021/acsbiomaterials.3c00483

Design and Validation of Hybrid Polymer‐Lipid Nanoparticles as Novel Transfection Vectors for MicroRNA Delivery to Human Cardiac Fibroblasts

Auteurs: Letizia Nicoletti, Camilla Paoletti, Martina Coletto, Elena Marcello, Giovanni Paolo Stola, Francesca Cossetta, Francesco Schiavone, Ilaria Andreana, Barbara Stella, Silvia Arpicco, Clara Mattu, Valeria Chiono
Publié dans: Advanced Healthcare Materials, 2025, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.202500971

Bioengineering Methods in MicroRNA-Mediated Direct Reprogramming of Fibroblasts Into Cardiomyocytes.

Auteurs: Camilla Paoletti; Valeria Chiono
Publié dans: Frontiers in Cardiovascular Medicine, Numéro 9, 2021, ISSN 2297-055X
Éditeur: Frontiers
DOI: 10.3389/fcvm.2021.750438

Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature

Auteurs: Sharon Wei Ling Lee, Marco Campisi, Tatsuya Osaki, Luca Possenti, Clara Mattu, Giulia Adriani, Roger Dale Kamm, Valeria Chiono
Publié dans: Advanced Healthcare Materials, Numéro 9/7, 2020, Page(s) 1901486, ISSN 2192-2640
Éditeur: John Wiley and Sons Ltd
DOI: 10.1002/adhm.201901486

Book chapters (2)

Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo

Auteurs: Camilla Paoletti, Carla Divieto, Valeria Chiono
Publié dans: Cardiac Gene Therapy. Methods in Molecular Biology, Numéro 2573, 2022, ISBN 978-1-0716-2706-8
Éditeur: Springer Protocols
DOI: 10.1007/978-1-0716-2707-5_3

Cell–biomaterial interactions: the role of ligand functionalization

Auteurs: Alice Zoso, Monica Boffito, Rossella Laurano, Irene Carmagnola, Valeria Chiono
Publié dans: Handbook of Biomaterials Biocompatibility, 2020, Page(s) 139-173, ISBN 9780081029671
Éditeur: Woodhead Publishing Series in Biomaterials - Elsevier
DOI: 10.1016/b978-0-08-102967-1.00009-8

Droits de propriété intellectuelle

Patent (1)

METHOD FOR THE PREPARATION OF HYBRID POLYMERIC NANOPARTICLES FOR THE RELEASE OF OLIGONUCLEOTIDE DRUGS IN PHARMACOLOGICAL THERAPIES FOR REGENERATIVE, CURATIVE, AND PREVENTIVE PURPOSES

Numéro de demande/publication: 22 843885
Date: 2022-12-22
Demandeur(s): POLITECNICO DI TORINO