Diagnosis and Management of Febrile Illness using RNA Personalised Molecular Signature Diagnosis

Informations projet

DIAMONDS

N° de convention de subvention: 848196

DOI

10.3030/848196

Date de signature de la CE 6 Decembre 2019

Date de début 1 Janvier 2020

Date de fin 31 Mars 2026

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 23 816 918,75

Contribution de l’UE

€ 22 582 021,13

Coordonné par

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (6)

Mid-Term recruitment report

MidTerm Recruitment Report M30 Overview of recruitment by study site including numbers recruiting problems and any measures made to compensate if recruitment delays occurred

Recruitment completion review

D1.4 Recruitment Completion Review [M42]. Completion of recruitment and patient assignment for all prospective samples and patient data sent for analysis. Includes report on the status of the study registry.

Consortium Data management plan

Consortium Data Management Plan [M3]

Kick-Off meeting report

Kick-Off meeting report [M1]

Stakeholder engagement plan

Stakeholder Engagement Plan [M12] Regular plan to allow periodical discussion and assessment of DIAMONDS progress.

Annual meeting reports

Annual Meeting Reports [M13, M31, M43, M55] Reports prepared following on from each consortium meeting, focusing on progress on major deliverables and milestones.

Open Research Data Pilot (1)

EDTL

Establishing a European Diagnostic Transcriptomic Library [M36]. A European library of gene expression data will be created in order to provide data for the molecular taxonomy of infectious and inflammatory diseases, and subsequent generation of the PMSD.

Websites, patent fillings, videos etc. (1)

Project website

Project Website [M4] Website will be developed at the earliest stage possible, maintained throughout the duration of the project, in collaboration with WP2.

Publications

Peer reviewed articles (20)

Biobanking and consenting to research: a qualitative thematic analysis of young people’s perspectives in the North East of England

Auteurs: Fabian J. S. van der Velden, Emma Lim, Lily Gills, Jasmin Broadey, Louise Hayes, Eve Roberts, Jack Courtney, Joanne Ball, Jethro Herberg, Rachel Galassini, Marieke Emonts & DIAMONDS consortium
Publié dans: BMC Medical Ethics, 2023, ISSN 1472-6939
Éditeur: BioMed Central
DOI: 10.1186/s12910-023-00925-w

Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Auteurs: Harsita Patel, Michael J. Carter, Heather Jackson, Oliver Powell, Matthew Fish, Manuela Terranova-Barberio, Filomena Spada, Nedyalko Petrov, Paul Wellman, Sarah Darnell, Sobia Mustafa, Katrina Todd, Cynthia Bishop, Jonathan M. Cohen, Julia Kenny, Sarah van den Berg, Thomas Sun, Francesca Davis, Aislinn Jennings, Emma Timms, Jessica Thomas, Maggie Nyirendra, Samuel Nichols, Leire Estamiana Elorieta
Publié dans: Nature Communications, Numéro 15, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-52246-0

The value of white blood cell count in predicting serious bacterial infections in children presenting to the emergency department: a multicentre observational study

Auteurs: Naomi Kemps, Clementien Vermont, Chantal D Tan, Ulrich von Both, Enitan Carrol, Marieke Emonts, Michiel van der Flier, Jethro Adam Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian Maconochie, Federico Martinón-Torres, Ruud Gerard Nijman, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Maria Tsolia, Dace Zavadska, Werner Zenz, Henriette A Moll, Joany M Zachariasse
Publié dans: Archives of Disease in Childhood, Numéro 110, 2025, Page(s) 191-196, ISSN 0003-9888
Éditeur: BMJ Publishing Group
DOI: 10.1136/archdischild-2024-327493

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Auteurs: Antonia Ho, Richard Orton, Rachel Tayler, Patawee Asamaphan, Vanessa Herder, Chris Davis, Lily Tong, Katherine Smollett, Maria Manali, Jay Allan, Konrad Rawlik, Sarah E. McDonald, Elen Vink, Louisa Pollock, Louise Gannon, Clair Evans, Jim McMenamin, Kirsty Roy, Kimberly Marsh, Titus Divala, Matthew T. G. Holden, Michael Lockhart, David Yirrell, Sandra Currie, Maureen O’Leary, David Henderson, Sa
Publié dans: Nature, 2023, ISSN 0028-0836
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-023-05948-2

Genomic investigations of unexplained acute hepatitis in children

Auteurs: Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Laura Atkinson, José Afonso Guerra-Assunção, Mahdi Moradi Marjaneh, Riccardo Zennezini Chiozzi, Nathaniel Storey, Luis Campos, J. Ciaran Hutchinson, John R. Counsell, Gabriele Pollara, Sunando Roy, Cristina Venturini, Juan F. Antinao Diaz, Ala’a Siam, Luke J. Tappouni, Zeinab Asgarian, Joanne Ng, Killian S. Hanlon, Alexander Len
Publié dans: Nature, 2023, ISSN 1476-4687
Éditeur: Nature Publishing Group
DOI: 10.1038/s41586-023-06003-w

A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia

Auteurs: Sandra Viz-Lasheras, Alberto Gómez-Carballa, Jacobo Pardo-Seco, Xabier Bello, Irene Rivero-Calle, Ana Isabel Dacosta, Myrsini Kaforou, Dominic Habgood-Coote, Aubrey J. Cunnington, Marieke Emonts, Jethro A. Herberg, Victoria J. Wright, Enitan D. Carrol, Stephane C. Paulus, Werner Zenz, Daniela S. Kohlfürst, Michiel Van der Flier, Ronald de Groot, Luregn J. Schlapbach, Philipp Agyeman, Andrew J. P
Publié dans: iScience, Numéro 28, 2025, Page(s) 111747, ISSN 2589-0042
Éditeur: Elsevier BV
DOI: 10.1016/j.isci.2025.111747

Group A streptococcal disease in paediatric inpatients:a European perspective

Auteurs: Navin P. Boeddha, Lucy Atkins, Ronald de Groot, Gertjan Driessen, Jan Hazelzet, Werner Zenz, Enitan D. Carrol, Suzanne T. Anderson, Federico Martinon-Torres, Philipp K. A. Agyeman, Rachel Galassini, Jethro Herberg, Michael Levin, Luregn J. Schlapbach, Marieke Emonts & EUCLIDS consortium
Publié dans: European Journal of Pediatrics, 2023, ISSN 1432-1076
Éditeur: SpringerLink
DOI: 10.1007/s00431-022-04787-z

External validation of a multivariable prediction model for identification of pneumonia and other serious bacterial infections in febrile immunocompromised children

Auteurs: Martin AJ, van der Velden FJS, von Both U on behalf of the PERFORM consortium, et al
Publié dans: Archives of Disease in Childhood, 2023, ISSN 0003-9888
Éditeur: BMJ Publishing Group
DOI: 10.1136/archdischild2023-325869

Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe

Auteurs: Laura Kolberg, Aakash Khanijau, Fabian J S van der Velden, Jethro Herberg, Tisham De, Rachel Galassini, Aubrey J Cunnington, Victoria J Wright, Priyen Shah, Myrsini Kaforou, Clare Wilson, Taco Kuijpers, Federico Martinón-Torres, Irene Rivero-Calle, Henriette Moll, Clementien Vermont, Marko Pokorn, Mojca Kolnik, Andrew J Pollard, Philipp K A Agyeman, Luregn J Schlapbach, Maria N Tsolia, Shunmay Ye
Publié dans: Clinical Infectious Diseases, 2023, ISSN 1058-4838
Éditeur: University of Chicago Press
DOI: 10.1093/cid/ciad615

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Auteurs: Samuel Channon-Wells; Ortensia Vito, Andrew J McArdle, Eleanor G Seaby, Harsita Patel, Priyen Shah, Ekaterina Pazukhina, Clare Wilson, Claire Broderick, Giselle D'Souza, Ilana Keren, Ruud G Nijman, Adriana Tremoulet, Daniel Munblit, Rolando Ulloa-Gutierrez, Michael J Carter, Padmanabhan Ramnarayan, Tisham De, Clive Hoggart, Elizabeth Whittaker, Jethro A Herberg, Myrsini Kaforou, Aubrey J Cunningto
Publié dans: The Lancet Rheumatology, 2023, ISSN 2665-9913
Éditeur: Elsevier
DOI: 10.1016/s2665-9913(23)00029-2

Adoption of C-reactive protein rapid tests for the management of acute childhood infections in hospitals in the Netherlands and England: a comparative health systems analysis

Auteurs: Juan Emmanuel Dewez, Ruud G. Nijman, Elizabeth J. A. Fitchett, Edmond C. Li, Queena F. Luu, Rebecca Lynch, Marieke Emonts, Ronald de Groot, Michiel van der Flier, Ria Philipsen, Stefanie Ettelt, Shunmay Yeung
Publié dans: BMC Health Services Research, Numéro 24, 2024, ISSN 1472-6963
Éditeur: BioMed Central
DOI: 10.1186/s12913-024-10698-6

Quantifying the costs of hospital admission for families of children with a febrile illness in the North East of England

Auteurs: Fabian Johannes Stanislaus van der Velden, Emma Lim, Holly Smith, Rebecca Walsh, Marieke Emonts
Publié dans: BMJ Paediatrics Open, Numéro 8, 2025, Page(s) e002489, ISSN 2399-9772
Éditeur: BMJ
DOI: 10.1136/bmjpo-2023-002489

Diagnosis of Multisystem Inflammatory Syndrome in Children by a Whole-Blood Transcriptional Signature

Auteurs: Heather R Jackson, Luca Miglietta, Dominic Habgood-Coote, Giselle D’Souza, Priyen Shah, Samuel Nichols, Ortensia Vito, Oliver Powell, Maisey Salina Davidson, Chisato Shimizu, Philipp K A Agyeman, Coco R Beudeker, Karen Brengel-Pesce, Enitan D Carrol, Michael J Carter, Tisham De, Irini Eleftheriou, Marieke Emonts, Cristina Epalza, Pantelis Georgiou, Ronald De Groot, Katy Fidler, Colin Fink, Dani
Publié dans: Journal of the Pediatric Infectious Diseases Society, 2023, ISSN 2048-7207
Éditeur: University of Chicago Press
DOI: 10.1093/jpids/piad035

A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment

Auteurs: Sandra Viz-Lasheras, Alberto Gómez-Carballa, Xabier Bello, Irene Rivero-Calle, Ana Isabel Dacosta, Myrsini Kaforou, Dominic Habgood-Coote, Aubrey J. Cunnington, Marieke Emonts, Jethro A. Herberg, Victoria J. Wright, Enitan D. Carrol, Stephane C. Paulus, Werner Zenz, Daniela S. Kohlfürst, Nina Schweintzger, Michiel Van der Flier, Ronald de Groot, Luregn J. Schlapbach, Philipp Agyeman, Andrew J. P
Publié dans: Nature Communications, Numéro 16, 2025, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-025-55932-9

Plasma Protein Biomarkers Distinguish Multisystem Inflammatory Syndrome in Children From Other Pediatric Infectious and Inflammatory Diseases

Auteurs: Sophya Yeoh, Diego Estrada-Rivadeneyra, Heather Jackson, Ilana Keren, Rachel Galassini, Samantha Cooray, Priyen Shah, Philipp Agyeman, Romain Basmaci, Enitan Carrol, Marieke Emonts, Colin Fink, Taco Kuijpers, Federico Martinon-Torres, Marine Mommert-Tripon, Stephane Paulus, Marko Pokorn, Pablo Rojo, Lorenza Romani, Luregn Schlapbach, Nina Schweintzger, Ching-Fen Shen, Maria Tsolia, Effua Usuf, Mic
Publié dans: Pediatric Infectious Disease Journal, Numéro 43, 2025, Page(s) 444-453, ISSN 0891-3668
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1097/inf.0000000000004267

Which low urgent triaged febrile children are suitable for a fast track? An observational European study

Auteurs: Chantal D Tan, Clementien L Vermont, Joany M Zachariasse, Ulrich von Both, Enitan D Carrol, Irini Eleftheriou, Marieke Emonts, Michiel van der Flier, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian K Maconochie, Federico Martinon-Torres, Ruud G Nijman, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Maria Tsolia, Werner Zenz, Dace Zavadska, Henriette A Moll
Publié dans: Emergency Medicine Journal, Numéro 41, 2025, Page(s) 236-241, ISSN 1472-0205
Éditeur: BMJ Publishing Group
DOI: 10.1136/emermed-2023-213375

Molecular Pathogen Testing for Identifying the Etiology of Febrile Illness in Immunocompromised Children

Auteurs: Fabian JS van der Velden, Priyen Shah, Marie Voice, Emma Lim, Jethro Herberg, Victoria Wright3, Tisham De, Enitan D. Carrol, Aakash Khanijau, Andrew J Pollard, Stéphane Paulus, Ulrich von Both8, Laura Kolberg, Clementien L Vermont, Nienke N Hagedoorn, Federico Martinón-Torres, Irene Rivero Calle, Philipp KA Agyeman, Luregn J Schlapbach, Maria Tsolia, Irini Eleftheriou, Marko Pokorn, Mojca Kolnik
Publié dans: Journal of Biotechnology and Biomedicine, 2023, ISSN 2642-9128
Éditeur: Fortune Journals
DOI: 10.26502/jbb.2642-91280100

Enhancing sepsis biomarker development: key considerations from public and private perspectives

Auteurs: Jean-Francois Llitjos, Enitan D. Carrol, Marcin F. Osuchowski, Marc Bonneville, Brendon P. Scicluna, Didier Payen, Adrienne G. Randolph, Stephan Witte, Jesus Rodriguez-Manzano, Bruno François, null null
Publié dans: Critical Care, Numéro 28, 2024, ISSN 1364-8535
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s13054-024-05032-9

Procalcitonin use in febrile children attending European emergency departments: a prospective multicenter study

Auteurs: Dorine M. Borensztajn, Joany M. Zachariasse, Enitan D. Carrol, Ruud G. Nijman, Ulrich von Both, Marieke Emonts, Jethro Herberg, Benno Kohlmaier, Michael Levin, Emma Lim, Ian K. Maconochie, Federico Martinón-Torres, Marko Pokorn, Irene Rivero-Calle, Aleksandra Rudzāte, Chantal D. Tan, Maria Tsolia, Clementien Vermont, Dace Zavadska, Werner Zenz, Henriette A. Moll, null null, Nienke N. Hagedoorn,
Publié dans: BMC Pediatrics, Numéro 25, 2025, ISSN 1471-2431
Éditeur: BioMed Central
DOI: 10.1186/s12887-025-05483-1

Heterozygous <i>BTNL8</i> variants in individuals with multisystem inflammatory syndrome in children (MIS-C)

Auteurs: Evangelos Bellos, Dilys Santillo, Pierre Vantourout, Heather R. Jackson, Amedine Duret, Henry Hearn, Yoann Seeleuthner, Estelle Talouarn, Stephanie Hodeib, Harsita Patel, Oliver Powell, Sophya Yeoh, Sobia Mustafa, Dominic Habgood-Coote, Samuel Nichols, Leire Estramiana Elorrieta, Giselle D’Souza, Victoria J. Wright, Diego Estrada-Rivadeneyra, Adriana H. Tremoulet, Kirsten B. Dummer, Stejara A. N
Publié dans: Journal of Experimental Medicine, Numéro 221, 2024, ISSN 0022-1007
Éditeur: Rockefeller University Press
DOI: 10.1084/jem.20240699