Obiettivo The goal of the CANCERSYS project is to establish a multi-scale model for two major signalling pathways involved in the formation of hepatocellular carcinoma, the beta-catenin and ras signalling pathways. Integrative studies linking measurements in primary heptocytes with effects at the organ level will address the impact of these signalling networks on proliferation, tissue organization and formation of hepatocellular carcinoma. In a close collaboration of scientists from theoretical fields and life sciences, our approach will combine dynamic modelling of signalling networks with spatial-temporal modelling of the liver microarchitecture. For this purpose dynamic models of the beta-catenin and ras core modules and their interactions will be integrated into a single-cell based three-dimensional model of the liver lobule. This model will be used to predict the impact of beta-catenin and ras activation on tissue organization starting with the early events, such as enhanced proliferation as well as micromotility of single cells, followed by formation of nodules and finally of dedifferentiated hepatocarcinomas. Predictions obtained by the model will be validated by inducible Apclox/lox and Ha-rasQ61R mouse strains, which have already been established by members of our consortium and allow induction of hepatocellular carcinoma. In addition the model predictions of the combined influence of active beta-catenin and ras signalling will be validated using a mouse strain that allows induction of both pathways in hepatocytes. In an iterative process, the model will be validated and adjusted to the in vivo situation. The model aims at the identification of systems properties of beta-catenin and ras signalling exploited during carcinogenesis and will foster the prediction of strategies for effective intervention, thereby facilitating the design of novel therapeutic strategies to combat hepatocellular carcinoma. Campo scientifico natural sciencesmathematicsapplied mathematicsmathematical model Parole chiave beta-catenin hepatocellular cancer liver microarchitecture multi-scale model primary hepatocytes signal transduction networks spatial-temporal modelling Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH-2007-2.1.2-5 - Multidisciplinary fundamental genomics and molecular biology approaches to study basic biological processes relevant to health and diseases Invito a presentare proposte FP7-HEALTH-2007-B Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ EV Contributo UE € 854 850,00 Indirizzo ARDEYSTRASSE 67 44139 Dortmund Germania Mostra sulla mappa Regione Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Michael Paul (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (8) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Germania Contributo UE € 250 800,00 Indirizzo FAHNENBERGPLATZ 79098 Freiburg Mostra sulla mappa Regione Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Jens Timmer (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET AUTOMATIQUE Francia Contributo UE € 273 300,00 Indirizzo DOMAINE DE VOLUCEAU ROCQUENCOURT 78153 Le Chesnay Cedex Mostra sulla mappa Regione Ile-de-France Ile-de-France Yvelines Tipo di attività Research Organisations Contatto amministrativo Sandrine Lassout (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germania Contributo UE € 280 800,00 Indirizzo IM NEUENHEIMER FELD 280 69120 Heidelberg Mostra sulla mappa Regione Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Tipo di attività Research Organisations Contatto amministrativo Bettina Crispin (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Francia Contributo UE € 280 800,00 Indirizzo RUE DE TOLBIAC 101 75654 Paris Mostra sulla mappa Regione Ile-de-France Ile-de-France Paris Tipo di attività Research Organisations Contatto amministrativo Annick Bertault (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato EBERHARD KARLS UNIVERSITAET TUEBINGEN Germania Contributo UE € 280 800,00 Indirizzo GESCHWISTER-SCHOLL-PLATZ 72074 Tuebingen Mostra sulla mappa Regione Baden-Württemberg Tübingen Tübingen, Landkreis Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Michael Schwarz (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAET LEIPZIG Germania Contributo UE € 280 800,00 Indirizzo RITTERSTRASSE 26 04109 Leipzig Mostra sulla mappa Regione Sachsen Leipzig Leipzig Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Rolf Gebhardt (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato STIFTELSEN FRAUNHOFER-CHALMERS CENTRUM FOR INDUSTRIMATEMATIK Svezia Contributo UE € 250 800,00 Indirizzo CHALMERS TEKNIKPARK 41288 GOETEBORG Mostra sulla mappa Regione Södra Sverige Västsverige Västra Götalands län Tipo di attività Research Organisations Contatto amministrativo Mats Jirstrand (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germania Contributo UE € 239 074,00 Indirizzo Chariteplatz 1 10117 Berlin Mostra sulla mappa Regione Berlin Berlin Berlin Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Eveline Fraessdorf (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato