Objectif The ageing society and demographic change is one of the major challenges which Europe is facing now, and even more so in the future. Mastering this challenge requires radically new diagnostic and therapeutic treatments as key factors in achieving the healthy well-being of European citizens. Molecular imaging (MI) plays a pivotal role in diagnosis, understanding of disease and in the development of effective treatments. CONQUER will explore a fundamentally new contrast mechanism with the potential to push magnetic resonance imaging (MRI) far beyond its limits towards a powerful MI modality. This will be achieved by exploiting the cross relaxation between 1H and large quadrupolar nuclei (QN) for contrast agent (CA) design. The main objective is to synthesize bio-compatible QN compounds and nano-particles (NPs), high efficiency and manifold degrees of freedom in the design of smart properties, such as the ability to switch the contrast on and off by changing the magnetic field or chemical binding (e.g. targeting). The NPs will be tailored based on quantum-mechanical simulations. Sensitivity and contrast switching will be demonstrated with MRI in cell cultures. This highly interdisciplinary project combines expertise in quantum physics, chemical and biomedical engineering, material characterisation as well as nanotoxicology. Today, European scientists and companies are already leading global players in CA development. CONQUER will significantly fertilise this field and lay the scientific foundations for a new technology by providing theoretical groundwork, synthesis guidelines, imaging instrumentation and toxicological references. These results will be actively transferred to academia and industry as well in order to strengthen European competitiveness. The combination of a so far unexploited quantum-mechanical phenomenon and cutting-edge imaging technologies has the potential to create MI solutions with significant impact. Champ scientifique natural sciencesphysical sciencesquantum physicsnatural scienceschemical sciencesinorganic chemistrypost-transition metalsnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopynatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesnatural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Thème(s) FETOPEN-RIA-2014-2015 - FET-Open research projects Appel à propositions H2020-FETOPEN-2014-2015 Voir d’autres projets de cet appel Sous appel H2020-FETOPEN-2014-2015-RIA Régime de financement RIA - Research and Innovation action Coordinateur TECHNISCHE UNIVERSITAET GRAZ Contribution nette de l'UE € 1 231 250,00 Adresse RECHBAUERSTRASSE 12 8010 Graz Autriche Voir sur la carte Région Südösterreich Steiermark Graz Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 1 231 250,00 Participants (4) Trier par ordre alphabétique Trier par contribution nette de l'UE Tout développer Tout réduire UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE Pologne Contribution nette de l'UE € 472 500,00 Adresse UL. OCZAPOWSKIEGO 2 10-719 OLSZTYN Voir sur la carte Région Makroregion północny Warmińsko-mazurskie Olsztyński Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 472 500,00 UNIVERZA V MARIBORU Slovénie Contribution nette de l'UE € 584 125,00 Adresse SLOMSKOV TRG 15 2000 Maribor Voir sur la carte Région Slovenija Vzhodna Slovenija Podravska Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 584 125,00 UMEA UNIVERSITET Suède Contribution nette de l'UE € 83 750,00 Adresse UNIVERSITETOMRADET 901 87 Umea Voir sur la carte Région Norra Sverige Övre Norrland Västerbottens län Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 83 750,00 MEDIZINISCHE UNIVERSITAT GRAZ Autriche Contribution nette de l'UE € 92 350,00 Adresse NEUE STIFTINGTALSTRASSE 6 8010 Graz Voir sur la carte Région Südösterreich Steiermark Graz Type d’activité Higher or Secondary Education Establishments Liens Contacter l’organisation Opens in new window Site web Opens in new window Participation aux programmes de R&I de l'UE Opens in new window Réseau de collaboration HORIZON Opens in new window Coût total € 92 350,00