Obiettivo The ageing society and demographic change is one of the major challenges which Europe is facing now, and even more so in the future. Mastering this challenge requires radically new diagnostic and therapeutic treatments as key factors in achieving the healthy well-being of European citizens. Molecular imaging (MI) plays a pivotal role in diagnosis, understanding of disease and in the development of effective treatments. CONQUER will explore a fundamentally new contrast mechanism with the potential to push magnetic resonance imaging (MRI) far beyond its limits towards a powerful MI modality. This will be achieved by exploiting the cross relaxation between 1H and large quadrupolar nuclei (QN) for contrast agent (CA) design. The main objective is to synthesize bio-compatible QN compounds and nano-particles (NPs), high efficiency and manifold degrees of freedom in the design of smart properties, such as the ability to switch the contrast on and off by changing the magnetic field or chemical binding (e.g. targeting). The NPs will be tailored based on quantum-mechanical simulations. Sensitivity and contrast switching will be demonstrated with MRI in cell cultures. This highly interdisciplinary project combines expertise in quantum physics, chemical and biomedical engineering, material characterisation as well as nanotoxicology. Today, European scientists and companies are already leading global players in CA development. CONQUER will significantly fertilise this field and lay the scientific foundations for a new technology by providing theoretical groundwork, synthesis guidelines, imaging instrumentation and toxicological references. These results will be actively transferred to academia and industry as well in order to strengthen European competitiveness. The combination of a so far unexploited quantum-mechanical phenomenon and cutting-edge imaging technologies has the potential to create MI solutions with significant impact. Campo scientifico natural sciencesphysical sciencesquantum physicsnatural scienceschemical sciencesinorganic chemistrypost-transition metalsnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopynatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesnatural sciencescomputer and information sciencessoftwaresoftware applicationssimulation software Programma(i) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Argomento(i) FETOPEN-RIA-2014-2015 - FET-Open research projects Invito a presentare proposte H2020-FETOPEN-2014-2015 Vedi altri progetti per questo bando Bando secondario H2020-FETOPEN-2014-2015-RIA Meccanismo di finanziamento RIA - Research and Innovation action Coordinatore TECHNISCHE UNIVERSITAET GRAZ Contribution nette de l'UE € 1 231 250,00 Indirizzo RECHBAUERSTRASSE 12 8010 Graz Austria Mostra sulla mappa Regione Südösterreich Steiermark Graz Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 1 231 250,00 Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo netto dell'UE Espandi tutto Riduci tutto UNIWERSYTET WARMINSKO MAZURSKI W OLSZTYNIE Polonia Contribution nette de l'UE € 472 500,00 Indirizzo UL. OCZAPOWSKIEGO 2 10-719 OLSZTYN Mostra sulla mappa Regione Makroregion północny Warmińsko-mazurskie Olsztyński Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 472 500,00 UNIVERZA V MARIBORU Slovenia Contribution nette de l'UE € 584 125,00 Indirizzo SLOMSKOV TRG 15 2000 Maribor Mostra sulla mappa Regione Slovenija Vzhodna Slovenija Podravska Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 584 125,00 UMEA UNIVERSITET Svezia Contribution nette de l'UE € 83 750,00 Indirizzo UNIVERSITETOMRADET 901 87 Umea Mostra sulla mappa Regione Norra Sverige Övre Norrland Västerbottens län Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 83 750,00 MEDIZINISCHE UNIVERSITAT GRAZ Austria Contribution nette de l'UE € 92 350,00 Indirizzo NEUE STIFTINGTALSTRASSE 6 8010 Graz Mostra sulla mappa Regione Südösterreich Steiermark Graz Tipo di attività Higher or Secondary Education Establishments Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Partecipazione a programmi di R&I dell'UE Opens in new window Rete di collaborazione HORIZON Opens in new window Costo totale € 92 350,00