Partnership for the Assessment of Risks from Chemicals

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

1st Report on national needs

The reports will describe the results of the first round of surveys launched among the NHs to identify the existing knowledge gaps, requests, suggestions and expertise. The reports will describe the suggestions formed and actions taken to promote the sustainable development of NHs.

1st PARC Extit Strategy Plan and sustainability report

1st PARC sustainability report - leader : INSERM (AE of ANSES)The sustainability report will describe the achievements of PARC and its legacy. It will describe strategic action plan for what will be done in the following period in addition to reporting on results of the different options for exit strategy and the initiatives that are taken to develop these options and eventually to implement them.

Report on the conceptual design and development guidelines of the PARC EWS

Report on the conceptual design and development guidelines of the PARC EWS - leader: SLU (AE of SEPA)This report will describe the conceptual design configuration of the early warning system envisaged in PARC coupling computational with analytical approaches to allow for integrative early warning regarding signals of the emergence of chemicals of concern in the environment and consumer and food products. The report will serve as the blueprint for the development of the system providing operational guidelines and user requirements translated into system requirements.

Report on the establishment of the interactions with SF and IB

The report will include the selection criteria and members of the SF and IB

PARC governance process timeline

Timeline providing the important input collection, meetings, reporting requirements

Report on the conceptual design of the integrative tools

Report on the conceptual design of the integrative toolsThis report will provide the description of the conceptual design configuration of the integrative modelling platform network to be developed by PARC in order to meet the research and regulatory questions expected in PARC linking to the data infrastructure developed in WP7 its software architecture, and a blueprint for software implementation.

1st Mapping of Needs report

This deliverables will describe the first exercise that will be perform to identify priorities for PARC from partners but also from third parties (as users of PARC results). These priorities will reflect the information needs of policy makers at both EU and national levels with regards to human and environmental exposure to chemicals and resulting health impacts. This will be done by engaging with the scientific community, regulatory entities and key stakeholders and harvesting their needs through surveys, workshops and documents that will specify regulatory needs and what activities and processes are necessary to achieve these objectives.

Report on the conceptual design of the SSbD toolbox

Report on the conceptual design of the SSbD toolbox This report will describe the conceptual design configuration of the SSbD toolbox, covering all aspects of the SSbD process and criteria for SSbD chemicals and materials. This document will be the blueprint for the further development of the SSbD toolbox. It will result from extended consultation with the relevant stakeholders and will ensure the full compliance with the SSbD criteria developed by the European Commission. The SSbD toolbox design will ensure that tools developed outside of PARC can be readily integrated into the toolbox.

Data Management Plan (DMP)

Data Management Plan (DMP) - Leader: TNO (AE of RIVM)

1st new AOPs report

1st new AOPs report - leader: INSERM (AE of ANSES)This report will summarize results from 5.3 on the AOPs. The report will give details on the developed AOPs and on the follow-up action to be taken to make the AOPs robust enough that regulators accept it. Additionally scientific achievements (publications, oral presentations etc.), presentations and discussion of the AOPs to 6.1 and to regulators (e.g. OECD).

Communication and Dissemination Strategy

Description of the Communication and Dissemination Strategy will be developed identifying target audiences and including a roadmap for the production of relevant communication materials and tools. 

1st Annual CL/ML reports' coordination and submission

First annual report on the activities developed by the CL/ML within PARC.

1st Report on citizen's perception and concern: results of the surveys and focus groups

1st Report on surveys and focus groups conducted to evaluate European citizens' perception and concerns on chemical exposure and risk assessment will be produced.

Rapid Response Report

In order to respond to new and urgent needs for information in the EU policy community and at national level, a rapid response mechanism will allow policy makers to submit requests for specific information. This deliverable will describe the process put in place in PARC to answer to these urgent needs and illustrate with first request if there is already one. These information requests may require new surveys on particular chemicals or in particular geographical regions (respecting the scope of countries included in PARC consortium).

Optimised list of indicators

Optimised list of indicators - leader: DOMG (AE of VITO)A monitoring and evaluation framework was already prepared, previous to PARC submission, including a long list of key performance indicators. It was used as basis for the PSIPS and KPI table (see First Biennial Monitoring Report for European Partnerships). This initial set of indicators will be further developed and optimised to prepare an optimised list of indicators for upcoming years. This will be done in collaboration with the MB, GSB and the GB, NHs and stakeholders, to ensure its relevance for evaluating the progress of the Partnership’s key, useful and impactful results. The list will include baselines and clear targets and will feed into the annual ASR reporting. A revised list will be produced on month 40 to be used within the mid-term review.

AWP Y3 including PARC Project Portfolio

Description of the activities to be implemented during year 3, including the updated PARC Project Portfolio with projects that are in the planning/executive phase

Ethics & Data Protection Policy

The PARC ethics and data protection framework will set out the collaborative processes to be implemented to ensure the monitoring of PARC’s actions concerning ethical considerations. It will provide the PARC ethical principles and procedures and will be developed in parallel and in coordination with the Data Management Plan under WP7.

1st Report on the testing and uptake of the SSbD toolbox through use cases

1st Report on the testing and uptake of the SSbD toolbox through use casesThe SSbD toolbox will be tested and validated in selected use cases that will be determined during year 1 of the project. This first report will give an account on the outcome of this selection process.

Description of a mechanism for selection of chemicals / matrices / endpoints for projects

Description of a mechanism for selection of chemicals / matrices / endpoints for projects - Leader: INERIS (AE of ANSES)Mechanism for identification of knowledge gaps concerning the presence of chemical contaminants in environmental matrices, food and consumer products, and identification of priority (groups of) substances deserving further monitoring actions. The process will build on existing successful frameworks and existing monitoring databases. The process will be aimed to provide monitoring project proposals.

PARC FAIR Data Policy (PFDP)

PARC FAIR Data Policy (PFDP) - Leader: TNO (AE of RIVM)This report will describe the PARC FAIR Data Policy, defining the (guiding) principles and conditions for management of data produced and/or used in PARC, in adherence with FAIR data principles and GDPR requirements, and specifying practices to take into account privacy, informed consent, security, transparency, sustainability and scalability, quality and reliability.

ASR Y3

Summary of the action, implemented activities and achievements during Y3

PARCopedia Scoping study

Report with the results from the scoping study for the implementation of a pilot of the Content Management System (CMS) for PARC (PARCopedia)

AWP Y2 including rolling SRIA

Description of the activities to be implemented during year 2, including the updated rolling SRIA with projects that are in the planning/executive phase

Report on Training events Y1
AWP Y1 including rolling SRIA

Description of the activities to be implemented during year 1 , including the updated rolling SRIA with projects that are in the planning/executive phase

Prioritisation criteria report

This deliverable will describe the criteria that will be used to rank the priorities (either for substances or groups of substances and methods) identified following the mapping of needs together with the targeted activities under the WPs. It will also document the process that has been used to agree on these criteria among PARC partners. The criteria might be related to hazardous properties of the substance/group and/or exposure and /or risk, either for human health or for the environment. For methods, the deliverable will develop criteria to identify the areas for which new methods and other innovative tools should be developed or standardised or pre-validated.

1st New approach methodologies report

1st New approach methodologies reportThis report will summarize results from 5.2 on the endpoints ED, (D)NT, NGtx-carc, immunotox, metabolic disruption. The report will give details on the developed NAMs and on the follow-up action to be taken to make the methods robust enough that regulators accept the results. Additionally scientific achievements (publications, oral presentations etc.), presentations of the NAMs to regulators.

ASR Y1

Summary of the action, implemented activities and achievements during Y1

PARCroute roadmap1

"Interim report on the work on the roadmap for the transition of the major European chemical regulation programs towards NGRA (""NGRAroute"")"

Database and roadmap for SYNnet

A database with partnerships, programmes, infrastructures, projects and other activities with which PARC can establish potential synergies and collaborations will be established and a roadmap developed for the establishment of these synergies.

Catalogues on environmental and biomonitoring networks Y1

The catalogues will gather under a common umbrella information on (bio)monitoring networks existing in the various risk assessment domains at national and European levels, related (meta)data, and sample collections. Catalogues on air monitoring networks, HBM, and articles will be built first and it is expected that pilot catalogues on air monitoring networks and HBM will be available within the first year of PARC. The catalogues will be regularly updated, initially assumed on an annual basis.

Laboratory catalogue and network platform (dashboard) Y1

The catalogue and network platform will gather and provide information and contacts on the existing laboratory capacities and networks within HBM and environmental monitoring under a common architecture. They will serve as a roadmap for users and stakeholders searching resources and capacities needed for next generation risk assessment. The catalogues and information provided there will be gradually built to finally encompass all the relevant risk assessment domains and updated (initially assuming) on an biannual basis.

PARCopedia

PARC’s knowledge management platform to facilitate the (co-)creation, organisation, contextualisation, and sharing/dissemination of the knowledge acquired by the Partnership in the form of a Content Management System (CMS) and discussion forum to connect the data landscape created by the data-generating WPs 4-6 and 8-9 (overseen by WP7) with one or more portals, embedded in the PARC website (overseen by WP3).

PARC website

PARC's website will support the dissemination of the partnership and contribute to increase PARC's visibility. A landing page with general information will be launched early in the project.

Pubblicazioni

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project

Autori: Marc Audebert 1, Ann-Sophie Assmann 2, Amaya Azqueta 3, Pavel Babica 4, Emilio Benfenati 5, Sylvie Bortoli 6, Peter Bouwman 7, Albert Braeuning 2, Tanja Burgdorf 2, Xavier Coumoul 6, Kloé Debizet 6, Maria Dusinska 8, Norman Ertych 2, Jörg Fahrer 9, Verena Fetz 2, Ludovic Le Hégarat 10, Adela López de Cerain 3, Harm J Heusinkveld 11, Kevin Hogeveen 10, Miriam N Jacobs 12, Mirjam Luijten 11, Giuseppa Raitano 5, Cynthia Recoules 1, Elise Rundén-Pran 8, Mariam Saleh 10, Iva Sovadinová 4, Martina Stampar 13, Lea Thibol 9, Céline Tomkiewicz 6, Ariane Vettorazzi 3, Bob Van de Water 7, Naouale El Yamani 8, Bojana Zegura 13, Michael Oelgeschläger 2
Pubblicato in: 2023
Editore: MDPI
DOI: 10.3389/FTOX.2023.1220998

Advancing exposure data analytics and repositories as part of the European Exposure Science Strategy 2020–2030

Autori: Marissa B. Kosnik a, Stylianos Kephalopoulos b, Amalia Muñoz c, Nicolò Aurisano a, Alberto Cusinato b, Sani Dimitroulopoulou d, Jaroslav Slobodnik e, Jonathas De Mello f, Maryam Zare Jeddi g, Claudia Cascio h, Andreas Ahrens i, Yuri Bruinen de Bruin j, Lothar Lieck j, Peter Fantke
Pubblicato in: Environment International, Numero 170, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2022.107610

From principles to reality. FAIR implementation in the nanosafety community

Autori: Verónica I. Dumit, Ammar Ammar, Martine I. Bakker, Miguel A. Bañares, Cecilia Bossa, Anna Costa, Hilary Cowie, Damjana Drobne, Thomas E. Exner, Lucian Farcal, Steffi Friedrichs, Irini Furxhi, Roland Grafström, Andrea Haase, Martin Himly, Nina Jeliazkova, Iseult Lynch, Dieter Maier, Cornelle W. Noorlander, Hyun Kil Shin, Penny Nymark
Pubblicato in: NANOTODAY, 2023
Editore: ELSEVIER
DOI: 10.1016/J.NANTOD.2023.101923

The Role of "Physiologically Based Pharmacokinetic Model (PBPK)" New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment

Autori: Deepika Deepika, Vikas Kumar
Pubblicato in: Int J Environ Res Public Health, 2023
Editore: MDPI
DOI: 10.3390/IJERPH20043473

Combined chronic dietary exposure to four nephrotoxic metals exceeds tolerable intake levels in the adult population of 10 European countries

Autori: R. Corinne Sprong,Annick D. van den BrandORCID Icon,Gerda van Donkersgoed,Urska Blaznik,Despo Christodoulou,Amélie Crépet,Maria da Graça Dias,Bodil Hamborg Jensen,Angelo Morretto,Elke Rauscher-Gabernig, Darja Sokolić, Jacob D. van Klaveren,Mirjam Luijten ANDMarcel J. B. Mengelers
Pubblicato in: Food Additives AND Contaminants: Part A, Numero 40, 2023
Editore: TAYLOR AND FRANCIS
DOI: 10.1080/19440049.2023.2272716

"""Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks"""

Autori: """Libor ˇSulc a,1, Tom´aˇs Janoˇs a,1, Daniel Figueiredo b, Ilse Ottenbros b,c, Petr ˇSenk a, Ondˇrej Mikeˇs a, Anke Huss b, Pavel ˇCupr a,*"""
Pubblicato in: Environmental Research, Numero 214 (2022) 114002, 2022, ISSN 0013-9351
Editore: Elsevier
DOI: 10.1016/j.envres.2022.114002

The European exposure science strategy 2020–2030

Autori: """Peter Fantke a,*, Yuri Bruinen de Bruin b,f, Urs Schlüter c, Alison Connolly d, Jos Bessems e, Stylianos Kephalopoulos f, Maryam Zare Jeddi g, An van Nieuwenhuyse h,i, Tatsiana Dudzina j, Paul T.J. Scheepers k, Natalie von Goetz l,m,*"""
Pubblicato in: Environment International, Numero 170 (2022) 107555, 2022, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2022.107555

Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women

Autori: Lucie Bláhová, Tomáš Janoš, Vicente Mustieles, Andrea Rodríguez-Carrillo, Mariana F. Fernández, Luděk Bláha
Pubblicato in: International Journal of Hygiene and Environmental Health, Numero 250, 2023
Editore: elsevier
DOI: 10.1016/J.IJHEH.2023.114175

A benchmark dataset for machine learning in ecotoxicology

Autori: Christoph Schür, Lilian Gasser, Fernando Perez-Cruz, Kristin Schirmer and Marco Baity-Jesi
Pubblicato in: Numero 10, 718, 2023
Editore: NATURE
DOI: 10.1038/S41597-023-02612-2

Determination of glyphosate and its derivative, aminomethylphosphonic acid, in human urine by gas chromatography coupled to tandem mass spectrometry and isotope pattern deconvolution

Autori: Eva Junqué a, Pilar Fernández a, Iohanna Filippi b, Joan O. Grimalt
Pubblicato in: Journal of Chromatography Open, Numero 4, 2023
Editore: ELSEVIER
DOI: 10.1016/J.JCOA.2023.100087

Combined western diet and bisphenol A exposure induces an oxidative stress-based paraoxonase 1 response in larval zebrafish

Autori: Rik van den Boom, Lucia Vergauwen, Noortje Koedijk, Katyeny Manuela da Silva, Adrian Covaci, Dries Knapen
Pubblicato in: 2023
Editore: ELSEVIER
DOI: 10.1016/J.CBPC.2023.109758

Environmental concentrations of tire rubber-derived 6PPD-quinone alter CNS function in zebrafish larvae

Autori: Marina Ricarte, Eva Prats, Nicola Montemurro, Juliette Bedrossiantz, Marina Bellot, Cristian Gómez-Canela, Demetrio Raldúa
Pubblicato in: Science of The Total Environment, Numero 896, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SCITOTENV.2023.165240

Rapid extraction and analysis of oxidative stress and DNA damage biomarker 8-hydroxy-2′-deoxyguanosine (8-OHdG) in urine: Application to a study with pregnant women

Framework for defining pesticide maximum residue levels in feed: applications to cattle and sheep

Autori: Zijian Li, Peter Fantke
Pubblicato in: PEST MANAGEMENT SCIENCE, Numero 79, 2, 2022
Editore: WILEY
DOI: 10.1002/PS.7241

New approach methods to improve human health risk assessment of thyroid hormone system disruption-a PARC project

Autori: Louise Ramhøj, Marta Axelstad, Yoni Baert, Ana I Cañas-Portilla, Frédéric Chalmel, Lars Dahmen, Antonio De La Vieja, Bertrand Evrard, Ann-Cathrin Haigis, Timo Hamers, Kim Heikamp, Henrik Holbech, Patricia Iglesias-Hernandez, Dries Knapen, Lorna Marchandis, Jane E Morthorst, Nikolai Georgiev Nikolov, Ana C V E Nissen, Michael Oelgeschlaeger, Kostja Renko, Vera Rogiers, Gerrit Schüürmann, Evelyn Stinckens, Mette H Stub, Monica Torres-Ruiz, Majorie Van Duursen, Tamara Vanhaecke, Lucia Vergauwen, Eva Bay Wedebye, Terje Svingen
Pubblicato in: Numero 17,5, 2023
Editore: PUBMED
DOI: 10.3389/FTOX.2023.1189303

Pharmacophore Modeling Using Machine Learning for Screening the Blood–Brain Barrier Permeation of Xenobiotics

Autori: Saurav Kumar, Deepika Deepika and Vikas Kumar
Pubblicato in: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Numero 19 (20), 2022
Editore: MDPI
DOI: 10.3390/IJERPH192013471

"""Generating environmental sampling and testing data for micro- and nanoplastics for use in life cycle impact assessment"""

Autori: """Cecilia Askhama,⁎, Valentina H. Pauna a,b, Anne-Marie Boulay c, Peter Fantke d, Olivier Jolliet d, Jérôme Lavoie e, Andy M. Booth f, Claire Coutris g, Francesca Verones h, MiriamWeber i, Martina G. Vijver j, Amy Lusher k,l, Carla Hajjar c"""
Pubblicato in: Science of the Total Environment, Numero 859 (2023) 160038, 2023, ISSN 0048-9697
Editore: Elsevier
DOI: 10.1016/j.scitotenv.2022.160038

FAIR environmental and health registry (FAIREHR)- supporting the science to policy interface and life science research, development and innovation

Autori: Maryam Zare Jeddi1, Karen S. GaleaKaren S. Galea, Susana Viegas, Susana Viegas, Peter Fantke, Peter Fantke, Henriqueta Louro, Henriqueta Louro, Jan Theunis, Jan Theunis, Eva Govarts, Eva GovartS, Sébastien Denys, Fillo Clémence Fillol, Loïc RambaudLoïc Rambaud, Marike Kolossa-GehringMarike Kolossa-Gehring, Tiina Santonen, Tiina Santonen, Hilko van der Voet, Hilko van der Voet, Manosij Ghosh, Manosij Ghosh, Carla Costa, Carla Costa, Joo Paulo Teixeira, João Paulo Teixeira, Hans Verhagen,Hans Verhagen, Radu-Corneliu Duca, Radu-Corneliu Duca, An Van Nieuwenhuyse, An Van Nieuwenhuyse, Kate Jones, Kate Jones, Craig Sams, Craig Sams, Ovnair Sepai, Ovnair Sepai, Giovanna Tranfo, Giovanna Tranfo, Martine Bakker, Martine Bakker, Nicole Palmen, Jacob van Klaveren, Jacob van Klaveren, Paul T. J. Scheepers, Paul T. J. Scheepers, Alicia Paini, Alicia Paini, Cristina Canova, Cristina Canova, Natalie von Goetz, Natalie von Goetz, Andromachi Katsonouri, Andromachi Katsonouri, Spyros Karakitsios, Spyros Karakitsios, Dimosthenis A. Sarigiannis, Dimosthenis A. Sarigiannis, Jos Bessems, Jos Bessems, Kyriaki Machera, Kyriaki Machera, Stuart Harrad, Stuart Harrad, Nancy B. Hopf, Nancy B. Hopf
Pubblicato in: FRONTIERS IN TECHNOLOGY, Numero 5, 2023
Editore: FRONTIERS
DOI: 10.3389/FTOX.2023.1116707

"""Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations"""

Autori: """Lola Bajard a, Ondrej Adamovsky a, Karine Audouze b, Kirsten Baken c, Robert Barouki b, Joost B. Beltman d, Anna Beronius e, Eva Cecilie Bonefeld-Jørgensen f,g, German Cano-Sancho h, Milo L. de Baat i, Filippo Di Tillio d, Mariana F. Fern´andez j,k,l, Re"
Pubblicato in: Environmental Research, Numero 217 (2023) 114650, 2023, ISSN 0013-9351
Editore: Academic Press
DOI: 10.1016/j.envres.2022.114650

Non-disclosure of developmental neurotoxicity studies obstructs the safety assessment of pesticides in the European Union

Autori: Axel Mie and Christina Rudén
Pubblicato in: Numero 22,44, 2023
Editore: Biomed Central
DOI: 10.1186/S12940-023-00994-9

A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides

Autori: Kristina Bartmann , Farina Bendt, Arif Dönmez, Daniel Haag, H. Eike Keßel, Stefan Masjosthusmann, Christopher Noel, Ji Wu, Peng Zhou, Ellen Fritsche
Pubblicato in: 2023
Editore: ALTEX
DOI: 10.14573/ALTEX.2206031

Exposure and hazard of bisphenol A, S and F: a multi-biomarker approach in three-spined stickleback

Autori: Corentin Mit, Rémy Beaudouin, Olivier Palluel, Cyril Turiès, Gaëlle Daniele, Barbara Giroud, Anne Bado-Nilles
Pubblicato in: Environmental Science and Pollution Research, Numero 32, 2025
Editore: SPRINGER NATURE
DOI: 10.1007/S11356-023-28462-4

Molecular and Functional Characterization of Different BrainSphere Models for Use in Neurotoxicity Testing on Microelectrode Arrays

Autori: Julia Hartmann, Noah Henschel, Kristina Bartmann, Arif Dönmez, Gabriele Brockerhoff, Katharina Koch and Ellen Fritsche
Pubblicato in: CELLS, Numero 12, 2023
Editore: MDPI
DOI: 10.3390/CELLS12091270

Advancing exposure knowledge and its uptake into policy: The European exposure science strategy 2020-2030 (Special Issue)

Autori: Peter Fantke, Natalie von Goetz, Matti Jantune
Pubblicato in: ENVIRONMENT INTERNATIONAL, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2022.107692

Link prediction in complex network using information flow

Autori: Furqan Aziz, Luke T. Slater, Laura Bravo-Merodio, Animesh Acharjee and Georgios V. Gkoutos
Pubblicato in: Scientific Reports, Numero 13, 2023
Editore: NATURE
DOI: 10.1038/S41598-023-41476-9

"""The exposure of Czech firefighters to perfluoroalkyl substances and polycyclic aromatic hydrocarbons: CELSPAC – FIREexpo case-control human biomonitoring study"""

Autori: """Katarína Řiháčková a, Aleš Pindur a,b,c, Klára Komprdová a, Nina Pálešová a, Jiří Kohoutek a, Petr Šenk a, Jana Navrátilová a, Lenka Andrýsková a, Ludmila Šebejová a, Richard Hůlek a, Mazen Ismael a, Pavel Čupr a,⁎"""
Pubblicato in: Science of the Total Environment, Numero 881 (2023) 163298, 2023, ISSN 0048-9697
Editore: Elsevier
DOI: 10.1016/j.scitotenv.2023.163298

"""Occupational and residential exposures to organophosphate and pyrethroid pesticides in a rural setting"""

Autori: Natalia Bravo, Merc`e Garí *, Joan O. Grimalt
Pubblicato in: Environmental Research, Numero 214 (2022) 114186, 2022, ISSN 0013-9351
Editore: Elsevier
DOI: 10.1016/j.envres.2022.114186

REACH out-numbered! The future of REACH and animal numbers

Autori: Costanza Rovida, Francois Busquet, Marcel Leist, Thomas Hartung
Pubblicato in: 2023
Editore: ALTEX
DOI: 10.14573/ALTEX.2307121

Learning from Safe-by-Design for Safe-and-Sustainable-by-Design: Mapping the current landscape of Safe-by-Design reviews, case studies, and frameworks

Autori: Akshat Sudheshwar, Christina Apel, Klaus Kümmerer, Zhanyun Wang, Lya G Soeteman-Hernández, Eugenia Valsami-Jones, Claudia Som, Bernd Nowack
Pubblicato in: ENVIRON INT, Numero 183, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2023.108305

CLUSplus: A decision tree-based framework for predicting structured outputs

Autori: Matej Petković, Jurica Levatić, Dragi Kocev, Martin Breskva, Sašo Džeroski
Pubblicato in: SoftwareX, Numero 24, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SOFTX.2023.101526

Further development of CometChip technology to measure DNA damage in vitro and in vivo: Comparison with the 2 gels/slide format of the standard and enzyme-modified comet assay

Autori: Miguel Collia, Peter Møller, Sabine A.S. Langie, Ariane Vettorazzi, Amaya Azqueta
Pubblicato in: TOXICOLOGY, Numero 501, 2023
Editore: ELSEVIER
DOI: 10.1016/J.TOX.2023.153690

Linking chemicals, genes and morphological perturbations to diseases

Autori: Natacha Cerisier, Bryan Dafniet, Anne Badel, Olivier Taboureau
Pubblicato in: Toxicol Appl Pharmacol, Numero 15, 2023
Editore: ELSEVIER
DOI: 10.1016/J.TAAP.2023.116407

Development of a rat physiologically based kinetic model (PBK) for three organophosphate flame retardants (TDCIPP, TCIPP, TCEP)

Autori: Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar
Pubblicato in: Toxicology Letters, Numero 383, 2023
Editore: ELSEVIER
DOI: 10.1016/J.TOXLET.2023.06.006

"""Development of a physiologically based toxicokinetic model for lead in pregnant women: The role of bone tissue in the maternal and fetal internal exposure"""

Autori: Yourdasmine Ali Daoud, Cleo Tebby, Remy Beaudouin, Celine Brochot
Pubblicato in: Toxicology and Applied Pharmacology, Numero 476 (2023) 116651, 2023, ISSN 0041-008X
Editore: Elsevier
DOI: 10.1016/j.taap.2023.116651

The environmental occurrence, fate, and risks of 25 endocrine disruptors in Slovenian waters

Autori: Andrej Grobin, Robert Roškar, Jurij Trontelj
Pubblicato in: Science of The Total Environment, Numero 906, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SCITOTENV.2023.167245

Metabolism-Disrupting Chemicals Affecting the Liver: Screening, Testing, and Molecular Pathway Identification

Autori: Kristin Fritsche, Andrea Ziková-Kloas, Philip Marx-Stoelting, Philip Marx-Stoelting and Albert Braeuning
Pubblicato in: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Numero 24 (3), 2023
Editore: MDPI
DOI: 10.3390/IJMS24032686

Toxicological effects of selenium nanoparticles in laboratory animals: A review

Autori: Yuliya V. Ryabova, Marina P. Sutunkova, Ilzira A. Minigalieva, Lada V. Shabardina, Tommaso Filippini, Aristides Tsatsakis
Pubblicato in: JOURNAL OF APPLIED TOXICOLOGY, Numero 44, 2023
Editore: WILEY
DOI: 10.1002/JAT.4499

Development of new approach methods for the identification and characterization of endocrine metabolic disruptors—a PARC project

Autori: Albert Braeuning, Albert Braeuning, Patrick Balaguer, Patrick Balaguer, William Bourguet, William Bourguet, Jordi Carreras-Puigvert, Jordi Carreras-Puigvert, Katreece Feiertag, Katreece Feiertag, Jorke H. Kamstra, Jorke H. Kamstra, Dries Knapen, Dries Knapen, Dajana Lichtenstein, Dajana Lichtenstein, Philip Marx-Stoelting, Philip Marx-Stoelting, Jonne Rietdijk, Jonne Rietdijk, Kristin Schubert, Kristin Schubert, Ola Spjuth, Ola Spjuth, Evelyn Stinckens, Evelyn Stinckens, Kathrin Thedieck, Kathrin Thedieck, Rik van den Boom, Rik van den Boom, Lucia Vergauwen, Lucia Vergauwen, Martin von Bergen, Martin von Bergen, Neele Wewer, Neele Wewer, Daniel ZalkoDaniel Zalko
Pubblicato in: FRONTIERS IN TOXICOLOGY, Numero 5, 2023
Editore: FRONTIERS
DOI: 10.3389/FTOX.2023.1212509

"""PBTK-TD model of the phagocytosis activity in three-spined stickleback exposed to BPA"""

Autori: """Corentin Mit a,b, Anne Bado-Nilles b, Cyril Turi`es b, Ga¨elle Daniele c, Barbara Giroud c, R´emy Beaudouin a,*"""
Pubblicato in: Aquatic Toxicology, Numero 261 (2023) 106608, 2023, ISSN 0166-445X
Editore: Elsevier
DOI: 10.1016/j.aquatox.2023.106608

Considering degradation kinetics of pesticides in plant uptake models: proof of concept for potato

Autori: Zijian Li, Peter Fantke
Pubblicato in: PEST MANAGEMENT SCIENCE, Numero 79, 2023
Editore: WILEY
DOI: 10.1002/PS.7288

"""Mixtures of per- and poly-fluoroalkyl substances (PFAS) reduce the in vitro activation of human T cells and basophils"""

Autori: """Ambra Maddalon a,1, Arkadiusz Pierzchalski b,1, Tobias Kretschmer b, Mario Bauer b, Ana C. Zenclussen b,c, Marina Marinovich a, Emanuela Corsini a, Gunda Herberth b,*"""
Pubblicato in: Chemosphere, Numero 336 (2023) 139204, 2023, ISSN 0045-6535
Editore: Elsevier
DOI: 10.1016/j.chemosphere.2023.139204

Development of historic monthly land use regression models of SO2, NOx and suspended particulate matter for birth cohort ELSPAC

Autori: Ondřej Mikeš, Ondřej Sáňka, Aneta Rafajová, Jelle Vlaanderen, Jie Chen, Gerard Hoek, Jana Klánová, Pavel Čupr
Pubblicato in: Atmospheric Environment, Numero 301, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ATMOSENV.2023.119688

Wild fish and seafood species in the western Mediterranean Sea with low safe mercury concentrations

Autori: Marco Capodiferro, Esther Marco, Joan O. Grimalt
Pubblicato in: Environmental Pollution, Numero 314, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVPOL.2022.120274

The mixture assessment or allocation factor: conceptual background, estimation algorithms and a case study example

Autori: Thomas Backhaus
Pubblicato in: Environmental Sciences Europe, Numero 35, 2023
Editore: SPRINGER
DOI: 10.1186/S12302-023-00757-W

IVIVE-PBPK based new approach methodology for addressing early life toxicity induced by Bisphenol A

Autori: Mengmei Ni, Deepika Deepika, Xiaomeng Li, Wei Xiong, Lishi Zhang, Jinyao Chen, Vikas Kumar
Pubblicato in: Environmental Research, Numero 240, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVRES.2023.117343

Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model

Autori: Marta Sendra, Martina Štampar, Katarina Fras, Beatriz Novoa, Antonio Figueras, Bojana Žegura
Pubblicato in: Environment International, Numero 171, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2022.107721

Carnosic Acid Ameliorates Indomethacin-Induced Gastric Ulceration in Rats by Alleviating Oxidative Stress and Inflammation

Autori: Betul Danisman, Betul Cicek, Serkan Yildirim, Ismail Bolat, Deniz Kantar, Kirill S. Golokhvast, Dragana Nikitovic,Aristidis Tsatsakis and Ali Taghizadehghalehjoughi
Pubblicato in: BIOMEDICINES, Numero 11, 2023
Editore: MDPI
DOI: 10.3390/BIOMEDICINES11030829

The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAM) in Pharmaceuticals and Environmental Chemical Risk Assessment

Autori: Deepika Deepika, andVikas Kumar
Pubblicato in: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2023
Editore: MDPI
DOI: 10.3390/IJERPH20043473

Protocol for designing INVITES-IN, a tool for assessing the internal validity of in vitro studies

Autori: Camilla Svendsen, Paul Whaley, Gunn E. Vist, Trine Husøy, Anna Beronius, Emma Di Consiglio, Ingrid Druwe, Thomas Hartung, Vasiliki I. Hatzi, Sebastian Hoffmann, Carlijn R. Hooijmans, Kyriaki Machera, Joshua F. Robinson,Erwin Roggen,Andrew A. Rooneyq, Nicolas Roth, Eliana Spilioti, Anastasia Spyropoulou, Olga Tcheremenskaia, Emanuela Testai, Mathieu Vinken and Gro H. Mathisen
Pubblicato in: Evidence-Based Toxicology, Numero 1, 2023
Editore: TAYLOR AND FRANCIS
DOI: 10.1080/2833373X.2023.2232415

SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex

Autori: Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Jules Imler, Céline Tomkiewicz-Raulet, Etienne B Blanc, Robert Barouki, Xavier Coumoul, Sylvie Bortol
Pubblicato in: 2023
Editore: PUBMED
DOI: 10.1016/J.ENVINT.2023.108219

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Autori: Ilinca Suciu, Johannes Delp, Simon Gutbier, Anna-Katharina Ückert, Anna-Sophie Spreng, Philipp Eberhard, Christiaan Karreman, Falk Schreiber, Katrin Madjar, Jörg Rahnenführer, Ivana Celardo, Ivano Amelio and Marcel Leist
Pubblicato in: antioxidants, Numero 12, 2022
Editore: MDPI
DOI: 10.3390/ANTIOX12010164

Prioritization of chemicals in food for risk assessment by integrating exposure estimates and new approach methodologies: A next generation risk assessment case study

Autori: Mirjam Luijten, R Corinne Sprong, Emiel Rorije, Leo T M van der Ven
Pubblicato in: Numero 19, 2022
Editore: FRONTIERS
DOI: 10.3389/FTOX.2022.933197

Ultra-low esfenvalerate exposure may disrupt interspecific competition

Autori: Florian Schunck, Matthias Liess
Pubblicato in: Science of The Total Environment, Numero 906, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SCITOTENV.2023.167455

Latent pesticide effects and their mechanisms

Autori: Matthias Liess, Jonas Gröning
Pubblicato in: Science of The Total Environment, Numero 909, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SCITOTENV.2023.168368

A data-derived reference mixture representative of European wastewater treatment plant effluents to complement mixture assessment

Autori: Liza-Marie Beckers, Rolf Altenburger, Werner Brack, Beate I. Escher, Jörg Hackermüller, Enken Hassold, Gianina Illing, Martin Krauss, Janet Krüger, Paul Michaelis, Andreas Schüttler, Sarah Stevens, Wibke Busch
Pubblicato in: Environment International, Numero 179, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2023.108155

A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe

Autori: P. Marx-Stoelting, G. Rivière, M. Luijten, K. Aiello-Holden, N. Bandow, K. Baken, A. Cañas, A. Castano, S. Denys, C. Fillol, M. Herzler, I. Iavicoli, S. Karakitsios, J. Klanova, M. Kolossa-Gehring, A. Koutsodimou, J. Lobo Vicente, I. Lynch, S. Namorado, S. Norager, A. Pittman, S. Rotter, D. Sarigiannis, M. J. Silva, J. Theunis, T. Tralau, M. Uhl, J. van Klaveren, L. Wendt-Rasch, E. Westerholm, C. Rousselle and P. Sanders
Pubblicato in: Archives of Toxicology, Numero 97, 2023
Editore: springer
DOI: 10.1007/S00204-022-03435-7

Impact of chemical mixtures from wastewater treatment plant effluents on human immune cell activation: An effect-based analysis

Autori: Ambra Maddalon, Arkadiusz Pierzchalski, Jannike Lea Krause, Mario Bauer, Saskia Finckh, Werner Brack, Ana C. Zenclussen, Marina Marinovich, Emanuela Corsini, Martin Krauss, Gunda Herberth
Pubblicato in: Science of The Total Environment, Numero 906, 2023
Editore: ELSEVIER
DOI: 10.1016/J.SCITOTENV.2023.167495

AOP-helpFinder 2.0: Integration of an event-event searches module

Autori: Thomas Jaylet, Thibaut Coustillet, Florence Jornod, Patricia Margaritte-Jeannin, Karine Audouze
Pubblicato in: 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2023.108017

"""Environmental and dietary determinants of metal exposure in four-year-old children from a cohort located in an industrial area (Asturias, Northern Spain)"""

Autori: Eva Junqu´e a,b, Adonina Tard´on c,d,e, Ana Fernandez-Somoano c,d,e, Joan O. Grimalt a,*
Pubblicato in: Environmental Research, Numero 214 (2022) 113862, 2022, ISSN 0013-9351
Editore: Elsevier
DOI: 10.1016/j.envres.2022.113862

A review on aquatic toxins - Do we really know it all regarding the environmental risk posed by phytoplankton neurotoxins?

Autori: Albano Pinto, Maria João Botelho, Catarina Churro, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira
Pubblicato in: Journal of Environmental Management, Numero 345, 2023
Editore: ELSEVIER
DOI: 10.1016/J.JENVMAN.2023.118769

"""Ecotoxicity characterization of chemicals: Global recommendations and implementation in USEtox"""

Autori: """Mikołaj Owsianiak a, Michael Z. Hauschild a,**, Leo Posthuma b,c, Erwan Saouter d,1, Martina G. Vijver e, Thomas Backhaus f, M´elanie Douziech g,h, Tamar Schlekat i, Peter Fantke a,*"""
Pubblicato in: Chemosphere, Numero 310 (2023) 136807, 2023, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.chemosphere.2022.136807

G × E interactions as a basis for toxicological uncertainty

Autori: Ilinca Suciu, David Pamies, Roberta Peruzzo, Petra H Wirtz, Lena Smirnova, Giorgia Pallocca, Christof Hauck, Mark T D Cronin, Jan G Hengstler, Thomas Brunner, Thomas Hartung, Ivano Amelio, Marcel Leist
Pubblicato in: ARCHIVES OF TOCXICOLOGY, Numero 97, 2023
Editore: SPRINGER
DOI: 10.1007/S00204-023-03500-9

Species composition and ecological structure of ground beetles (Coleoptera, Carabidae) communities as biological indicators of the agro-environmental sustainability

Autori: K. Yu Maksimovich, R. Yu Dudko b, E.I. Shatalova, A.K. Tsakalof, A.M. Tsatsakis, K.S. Golokhvast, E.A. Novikov
Pubblicato in: Environmental Research, Numero 234, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVRES.2023.116030

"""Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals"""

Autori: """Mikołaj Owsianiak a, Michael Z. Hauschild a,**, Leo Posthuma b,c, Erwan Saouter d,1, Martina G. Vijver e, Thomas Backhaus f, M´elanie Douziech g,h, Tamar Schlekat i, Peter Fantke a,*"""
Pubblicato in: Chemosphere, Numero 311 (2023) 137035, 2023, ISSN 0045-6535
Editore: Elsevier
DOI: 10.1016/j.chemosphere.2022.137035

Expression Profiles of Genes Related to Development and Progression of Endometriosis and Their Association with Paraben and Benzophenone Exposure

Autori: Francisco M Peinado, Alicia Olivas-Martínez, Inmaculada Lendínez, Luz M Iribarne-Durán, Josefa León, Mariana F Fernández, Rafael Sotelo, Fernando Vela-Soria, Nicolás Olea, Carmen Freire, Olga Ocón-Hernández, Francisco Artacho-Cordón
Pubblicato in: Numero 24,23, 2023
Editore: pubmed
DOI: 10.3390/IJMS242316678

Human Exposure to Bisphenols, Parabens, and Benzophenones, and Its Relationship with the Inflammatory Response: A Systematic Review

Autori: Francisco Manuel Peinado 1, Luz María Iribarne-Durán 1, Francisco Artacho-Cordón
Pubblicato in: Numero 24,8, 2023
Editore: PUBMED
DOI: 10.3390/IJMS24087325

Pesticide effect on earthworm lethality via interpretable machine learning

Autori: Mihkel Kotli, Geven Piir, Uko Maran
Pubblicato in: Journal of Hazardous Materials, Numero 461, 2023
Editore: ELSEVIER
DOI: 10.1016/J.JHAZMAT.2023.132577

A review on immunomodulatory effects of BPA analogues

Autori: Anja Kodila, Nina Franko and Marija Sollner Dolenc
Pubblicato in: ARCHIVES OF TOXICOLOGY, Numero 97, 2023
Editore: SPRINGER
DOI: 10.1007/S00204-023-03519-Y

Cardiac PI3K p110α attenuation delays aging and extends lifespan

Autori: Mahmoud Abdellatif, Tobias Eisenberg, Alexander Martin Heberle, Kathrin Thedieck, Guido Kroemer, Simon Sedej
Pubblicato in: 2022
Editore: HAL
DOI: 10.15698/CST2022.08.270

Modernizing persistence–bioaccumulation–toxicity (PBT) assessment with high throughput animal-free methods

Autori: Beate I. Escher, Rolf Altenburger, Matthias Blüher, John K. Colbourne, Ralf Ebinghaus, Peter Fantke, Michaela Hein, Wolfgang Köck, Klaus Kümmerer, Sina Leipold, Xiaojing Li, Martin Scheringer, Stefan Scholz, Michael Schloter, Pia-Johanna Schweizer, Tamara Tal, Igor Tetko, Claudia Traidl-Hoffmann, Lukas Y. Wick and Kathrin Fenner
Pubblicato in: Archives of Toxicology, Numero 97, 2023
Editore: SPRINGER
DOI: 10.1007/S00204-023-03485-5

Acetylcholinesterase Inhibition in Rats and Humans Following Acute Fenitrothion Exposure Predicted by Physiologically Based Kinetic Modeling-Facilitated Quantitative In Vitro to In Vivo Extrapolation

Autori: Jiaqi Chen, Shensheng Zhao, Sebastiaan Wesseling, Nynke I. Kramer, Ivonne M.C.M. Rietjens, Hans Bouwmeester
Pubblicato in: Environmental Science and Technology, Numero 57, 49, 2023
Editore: acs
DOI: 10.1021/ACS.EST.3C07077

Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study)

Autori: Nina Pálešová, Léa Maitre, Nikos Stratakis, Katarína Řiháčková, Aleš Pindur, Jiří Kohoutek, Petr Šenk, Anna Bartošková Polcrová, Petr Gregor, Martine Vrijheid, Pavel Čupr
Pubblicato in: 2023
Editore: ELSEVIER
DOI: 10.1016/J.IJHEH.2023.114215

Adverse outcome pathway-based analysis of liver steatosis in vitro using human liver cell lines

Autori: Mawien Karaca, Kristin Fritsche, Dajana Lichtenstein, Özlem VuraL, Katrin Kreuzer, Jimmy Alarcan, Albert Braeuning, Philip Marx-Stoelting, Tewes Tralau
Pubblicato in: STAR PROTOCOLS, Numero 4,3, 2023
Editore: ELSEVIER
DOI: 10.1016/J.XPRO.2023.102500

Mapping chemical footprints of organic micropollutants in European streams

Autori: Saskia Finckh, Eric Carmona, Dietrich Borchardt, Olaf Büttner, Martin Krauss, Tobias Schulze, Soohyun Yang, Werner Brack
Pubblicato in: Environment International, Numero 183, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2023.108371

Current-use pesticide exposure pathways in Czech adults and children from the CELSPAC-SPECIMEn cohort

Autori: Libor Šulc, Daniel Figueiredo, Anke Huss, Jiří Kalina, Petr Gregor, Tomáš Janoš, Petr Šenk, Andrea Dalecká, Lenka Andrýsková, Vít Kodeš, Pavel Čupr
Pubblicato in: Environment International, Numero 181, 2023
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2023.108297

Interpretable machine learning for the identification of estrogen receptor agonists, antagonists, and binders

Autori: Geven Piir, Sulev Sild, Uko Maran
Pubblicato in: CHEMOSPHERE, Numero 347, 2023
Editore: ELSEVIER
DOI: 10.1016/J.CHEMOSPHERE.2023.140671

Endocrine disrupting chemicals entering European rivers: Occurrence and adverse mixture effects in treated wastewater

Autori: Saskia Finckh, Sebastian Buchinger, Beate I. Escher, Henner Hollert b, Maria König, Martin Krauss, Warich Leekitratanapisan, Sabrina Schiwy , Rita Schlichting, Aliaksandra Shuliakevich, Werner Brack
Pubblicato in: Environment International, Numero 170, 2022
Editore: ELSEVIER
DOI: 10.1016/J.ENVINT.2022.107608

Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment

Autori: Thalia De Castelbajac Thalia De Castelbajac1 Kiara Aiello ;Kiara Aiello Celia Garcia Arenas ;Celia Garcia Arenas Terje Svingen Terje Svingen Louise Ramh jLouise Ramhøj Daniel Zalko Daniel Zalko Robert Barouki Robert Barouki Tamara Vanhaecke Tamara Vanhaecke Vera Rogiers Vera Rogiers Marc Audebert Marc Audebert Michael Oelgeschlaeger Michael Oelgeschlaeger Albert Braeuning Albert Braeuning Etienne Blanc Etienne Blanc Tamara Ta Tamara Tal Joëlle Rüegg Joëlle Rüegg Ellen FritscheEllen Fritsche Philip Marx-Stoelting;Philip Marx-Stoelting Gilles Rivi;Gilles Rivière
Pubblicato in: 2023
Editore: FRONTIERS
DOI: 10.3389/FTOX.2023.1216369

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