Obiettivo
"Evidence of the impact of long-acting spatial repellents (LASR) on malaria burden is urgently needed. We propose to conduct a rigorous, cluster-randomised trial to evaluate the effectiveness of LASR and indoor residual spraying (IRS) in Kenya. The trial will include 66 clusters (villages) in western Kenya where malaria transmission is intense. The clusters will be randomised to one of three study arms including: (1) LASR (intervention #1) with SC Johnson’s Guardian™ product, (2) IRS with pirimiphos-methyl (intervention #2), and (3) standard control (no intervention). All clusters will receive standard malaria control interventions, including long-lasting insecticidal nets (LLINs) distributed by the Kenyan National Malaria Control Program and malaria vaccines (as and when these are deployed). The evaluation will include repeated cross-sectional community surveys (conducted at baseline and then every 6 months for 2 years) to gather information on household characteristics and parasite prevalence in children aged 2-10 years, malaria incidence as captured through health facility surveillance, entomological surveillance, mosquito behaviour studies and insecticide resistance monitoring, qualitative research to explore barriers to delivering LASR and IRS, and an economic evaluation. The primary objective of the study is to evaluate the impact of LASR (Guardian™) as compared to standard control on parasite prevalence in western Kenya. We will test the hypothesis that parasite prevalence as measured in cross-sectional surveys will be lower in intervention clusters (villages randomised to receive LASR), than in control clusters (villages randomised to standard control). The field work in Kenya will be led by the Kenya Medical Research Institute (KEMRI), coordinated by the Liverpool School of Tropical Medicine (LSTM), and supported by Radboud University Medical Centre, Netherlands, the Institute of Tropical Medicine, Belgium, and the US Centers of Disease Control."
Campo scientifico (EuroSciVoc)
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP. Cfr.: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP. Cfr.: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- scienze mediche e della salutemedicina di basefarmacologia e farmaciafarmacivaccini
- scienze naturaliscienze biologichezoologiazoologia degli invertebrati
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Parole chiave
Programma(i)
- HORIZON.2.1 - Health Main Programme
Invito a presentare proposte
(si apre in una nuova finestra) HORIZON-JU-GH-EDCTP3-2024-01-two-stage
Vedi altri progetti per questo bandoMeccanismo di finanziamento
HORIZON-JU-RIA -Coordinatore
L3 5QA LIVERPOOL 3
Regno Unito