Objective
Organocatalytic analogues of transition metal catalysts can future-proof organic synthesis against the depletion of metals, improve the sustainability of chemical production, circumvent catalyst deactivation by Lewis-basic motifs, and avoid toxic metal impurities in drugs. Organocatalytic strategies for the reduction of unactivated C=C bonds and the C–C cross-coupling of unactivated halides, which are among the most common transformations in medicinal chemistry, remain difficult to develop with broad scope as oxidative substrate activation requires highly reactive species. Photocatalysis is a potential solution since it can selectively activate even unreactive motifs under mild conditions. Yet, the generated open-shell species are often difficult to control without a metal co-catalyst. EDA complexes, which have emerged as a photocatalyst-free means for light-mediated reactions, in principle, enable selective transformations without a metal co-catalyst by proximity-control within contact ion pairs. In practice, however, such reactions often depend on a fragmentation step that generates free radicals, which are subject to the same limitations as those generated by classical photocatalysis. Project ORTHOCAT aims to achieve selective organophotocatalytic C=C bond reduction and C–C cross-coupling reactions via rearrangement reactions of contact ion pairs derived from EDA complexes with ortho-disubstituted arenes. The key design principle is the bond polarization upon single electron transfer, which enables a nucleophilic substitution step that mimics migratory insertion or reductive elimination steps of transition metal mediated reactions. The successful development of this proposal will establish an orthogonal catalysis strategy, address the pervasive and vexing deactivation of Lewis-acidic metal catalysts in medicinal chemistry, and enable new transformations to sought-after motifs.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis photocatalysis
- natural sciences chemical sciences organic chemistry hydrocarbons
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
42119 Wuppertal
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.