Objective
Network meta-analysis is an extension of pairwise meta-analysis and is considered the highest possible level of clinical evidence. However, the increasing complexity and the evolving nature of recent public health questions impose new challenges that cannot be addressed by existing evidence synthesis approaches, such as complexity of new interventions, environmental and socio-political changes, or new technologies and misinformation. Thus, there is an urgent need for developing a new knowledge synthesis framework that would enable considering jointly the totality of evidence on an entire domain and would account for all important factors affecting individualized recommendations and global health policies. The aim of the proposed research program is to conceptualize, develop, and establish the “Knowledge and Learning Integration Dynamic Open (KaLeIDO) System” framework to provide a paradigm shift in comparative effectiveness research. The KaLeIDO-CARE program will develop new statistical methods for a) combining information across multiple subpopulations, b) dismantling the complexity of different healthcare strategies, and c) tailoring clinical recommendations to individuals’ characteristics and preferences. The new framework will be publicly accessible to be applied across all health domains while accounting for rapidly changing variables. By implementing artificial intelligence tools, I will facilitate communication of the findings, and will promote transparency, open science, and research collaboration. The new framework will be evaluated and established through a proof-of-concept application that will produce comprehensive recommendations for the management of hypertension for every individual. My international recognition as a leader in evidence synthesis with a track-record of pioneering innovative methodologies and proven ability to build multidisciplinary collaborations, uniquely positions me to drive this transformative initiative for public health.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
0313 Oslo
Norway
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.