Objective
The overarching goal of my proposal is to deliver multimorbidity research that challenges and re-designs current thinking by combining agnostic, i.e. hypothesis-free discovery approaches with targeted hypothesis testing, bespoke experimental follow-up and validation. My proposal is to consider and integrate data across all diseases in diverse populations and at different life stages with focused clinical challenges and in-depth molecular investigations. By building and leading a team that delivers data-driven, solution-oriented multimorbidity science, I will address the following synergistic objectives structured to deliver my 3 main aims: 1) systematically map disease co-occurrence and estimate the prognostic impact of having multiple diseases, 2) accelerate early detection by identifying those at risk of developing disease clusters with the highest prognostic impact, and 3) enable precision prevention by understanding the underlying molecular mechanisms, i.e. shared causes driving the development of multiple diseases using multi-omic approaches at single-cell resolution and across the whole spectrum of common and rare diseases. The data opportunities and methods brought together to deliver this work reflect the reality of the ethnic and pathological diversity present in modern society with profound inequalities and thereby enable translatable solutions to clinical challenges that matter globally. The agnostic investigations of this proposal will identify and map previously unsuspected connections across diseases, organs and pathologies; a fundamentally different, data-driven computational approach that is complemented by scientifically prioritised, pre-specified investigations, and enables their parallel pursuit through the results it generates. I have provided scientific leadership for each of these currently separate areas, brought together here for the first time, and the transdisciplinary nature of my proposal reflects the reality of my professional profile.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2025-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
E1 4NS LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.