Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952

Informations projet

AMYPAD

N° de convention de subvention: 115952

DOI

10.3030/115952

Projet clôturé

Date de signature de la CE 8 Novembre 2016

Date de début 1 Octobre 2016

Date de fin 30 Septembre 2022

Financé au titre de

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Coût total

€ 27 329 288,00

Contribution de l’UE

€ 11 999 886,00

Coordonné par

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (1)

Open-source software suite for quantification of amyloid PET images

Report and demo of an opensource software suite for amyloid PET quantification will be developed to make available to the medical and scientific communities all the methodological developments that will be developed in AMYPAD including dynamic image quantification

Publications

Peer reviewed articles (36)

Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease

Auteurs: Julia Pfeil, Merle C. Hoenig, Elena Doering, Thilo van Eimeren, Alexander Drzezga, Gérard N. Bischof
Publié dans: Neurobiology of Aging, 2021, ISSN 0197-4580
Éditeur: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2021.06.014

Ethical Frameworks for Disclosure of Alzheimer Disease Biomarkers to Research Participants: Conflicting Norms and a Nuanced Policy

Auteurs: Eline M. Bunnik, Marthe Smedinga, Richard Milne, Jean Georges, Edo Richard, Maartje H. N. Schermer
Publié dans: Ethics and Human Research, 2022, ISSN 2578-2363
Éditeur: The Hastings Center
DOI: 10.1002/eahr.500146

NiftyPAD Novel Python package for quantitative analysis of dynamic PET data

Auteurs: Jieqing Jiao, Fiona Heeman, Rachael Dixon, Catriona Wimberley, Isadora Lopes Alves, Juan Domingo Gispert, Adriaan A. Lammertsma, Bart N. M. van Berckel, Casper da Costa-Luis, Pawel Markiewicz, David M. Cash, M Jorge Cardoso, Sebastién Ourselin, Maqsood Yaqub, Frederik Barkhof
Publié dans: Neuroinformatics, 2023, ISSN 2213-1582
Éditeur: Elsevier BV
DOI: 10.1007/s12021-022-09616-0

Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults

Auteurs: Emma S. Luckett, Yasmina Abakkouy, Mariska Reinartz, Katarzyna Adamczuk, Jolien Schaeverbeke, Sare Verstockt, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen, Rik Vandenberghe
Publié dans: Alzheimer’s Research and Therapy, 2022, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1186/s13195-022-01079-4

Parametric imaging of dual-time window [18F]flutemetamol and [18F]florbetaben studies

Auteurs: Fiona Heeman, Maqsood Yaqub, Janine Hendriks, Ilona Bader, Frederik Barkhof, Juan Domingo Gispert, Bart N.M. van Berckel, Isadora Lopes Alves, Adriaan A. Lammertsma
Publié dans: NeuroImage, Numéro 234, 2021, Page(s) 117953, ISSN 1053-8119
Éditeur: Academic Press
DOI: 10.1016/j.neuroimage.2021.117953

Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias

Auteurs: Gaël Chételat, Javier Arbizu, Henryk Barthel, Valentina Garibotto, Ian Law, Silvia Morbelli, Elsmarieke van de Giessen, Federica Agosta, Frederik Barkhof, David J Brooks, Maria C Carrillo, Bruno Dubois, Anders M Fjell, Giovanni B Frisoni, Oskar Hansson, Karl Herholz, Brian F Hutton, Clifford R Jack, Adriaan A Lammertsma, Susan M Landau, Satoshi Minoshima, Flavio Nobili, Agneta Nordberg, Rik Osse
Publié dans: The Lancet Neurology, Numéro 19/11, 2020, Page(s) 951-962, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(20)30314-8

Regional associations of white matter hyperintensities and early cortical amyloid pathology

Auteurs: Luigi Lorenzini, Loes T Ansems, Isadora Lopes Alves, Silvia Ingala, David Vállez García, Jori Tomassen, Carole Sudre, Gemma Salvadó, Mahnaz Shekari, Gregory Operto, Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Mara Ten Kate, Betty Tijms, Alle Meije Wink, Henk J M M Mutsaerts, Anouk den Braber, Pieter Jelle Visser, Bart N M van Berckel, Juan Domingo Gispert, Frederik Barkhof, Lyduine E Coll
Publié dans: Brain, 2022, ISSN 0006-8950
Éditeur: Oxford University Press
DOI: 10.1093/braincomms/fcac150

[11C]PIB amyloid quantification: effect of reference region selection

Auteurs: Fiona Heeman, Janine Hendriks, Isadora Lopes Alves, Rik Ossenkoppele, Nelleke Tolboom, Bart N. M. van Berckel, Adriaan A. Lammertsma, Maqsood Yaqub
Publié dans: EJNMMI Research, Numéro 10/1, 2020, ISSN 2191-219X
Éditeur: Springer Berlin
DOI: 10.1186/s13550-020-00714-1

Should doctors offer biomarker testing to those afraid to develop Alzheimer’s dementia? – Applying the method of reflective equilibrium for a clinical dilemma

Auteurs: Marthe Smedinga, Eline M Bunnik, Edo Richard, Maartje H N Schermer
Publié dans: Journal of bioethical inquiry, 2022, ISSN 1176-7529
Éditeur: University of Otago Press
DOI: 10.1007/s11673-022-10167-x

Spatial-Temporal Patterns of Amyloid-β Accumulation: A Subtype and Stage Inference Model Analysis

Auteurs: Lyduine E. Collij, Gemma Salvadó, Viktor Wottschel, Sophie E Mastenbroek, Pierre Schoenmakers, Fiona Heeman, Leon Aksman, Alle Meije Wink, Bart N.M. Berckel, Wiesje M van de Flier, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof, Sven Haller, Juan Domingo Gispert, Isadora Lopes Alves,.
Publié dans: Neurology, 2022, ISSN 0213-4853
Éditeur: Ediciones Doyma S.A.
DOI: 10.1212/wnl.0000000000200148

Longitudinal pathways of cerebrospinal fluid and positron emission tomography biomarkers of amyloid-β positivity

Auteurs: Arianna Sala, Agneta Nordberg, Elena Rodriguez-Vieitez
Publié dans: Molecular Psychiatry, 2020, ISSN 1359-4184
Éditeur: Nature Publishing Group
DOI: 10.1038/s41380-020-00950-w

Impact of cereberal blood flow and amyloid load on SUVR Bias

Auteurs: Fiona Heeman, Maqsood Yaqub, Janine Hendriks, Bart N. M. van Berckel, Lyduine E. Collij, Katherine R. Gray, Richard Manber, Robin Wolz, Valentina Garibotto, Catriona Wimberley, Craig Ritchie, Frederik Barkhof, Juan Domingo Gispert, David Vállez García, Isadora Lopes Alves & Adriaan A. Lammertsma on behalf of the AMYPAD Consortium
Publié dans: European Journal of Nuclear Medicine and Molecular Imaging, 2022, ISSN 1619-7070
Éditeur: Springer Verlag
DOI: 10.1186/s13550-022-00898-8

Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals

Auteurs: Lyduine E. Collij, Sophie E. Mastenbroek, Gemma Salvadó, Alle Meije Wink, Pieter Jelle Visser, Frederik Barkhof, Bart. N.M. Berckel, Isadora Lopes Alves
Publié dans: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Numéro 13/1, 2021, ISSN 2352-8729
Éditeur: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
DOI: 10.1002/dad2.12216

Analysis of Psychological Symptoms Following Disclosure of Amyloid–Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline

Auteurs: Camilla Caprioglio, Federica Ribaldi, Leonie N. C. Visser, Carolina Minguillon, Lyduine E. Collij, Oriol Grau-Rivera, Philip Zeyen, José Luis Molinuevo, Juan Domingo Gispert, Valentina Garibotto, Christian Moro, Zuzana Walker, Paul Edison, Jean-François Demonet, Frederik Barkhof, Philip Scheltens, Isadora Lopes Alves, Rossella Gismondi, Gill Farrar, Andrew W. Stephens, Frank Jessen, Giovanni B.
Publié dans: Jama Network, 2022, ISSN 0098-7484
Éditeur: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.50921

Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent

Auteurs: Lyduine E. Collij, Gemma Salvadó, Mahnaz Shekari, Isadora Lopes Alves, Juhan Reimand, Alle Meije Wink, Marissa Zwan, Aida Niñerola-Baizán, Andrés Perissinotti, Philip Scheltens, Milos D. Ikonomovic, Adrian P. L. Smith, Gill Farrar, José Luis Molinuevo, Frederik Barkhof, Christopher J. Buckley, Bart N. M. van Berckel, Juan Domingo Gispert
Publié dans: European Journal of Nuclear Medicine and Molecular Imaging, Numéro 48/7, 2021, Page(s) 2169-2182, ISSN 1619-7070
Éditeur: Springer Verlag
DOI: 10.1007/s00259-020-05174-2

Strategies to reduce sample sizes in Alzheimer’s disease primary and secondary prevention trials using longitudinal amyloid PET imaging

Auteurs: Isadora Lopes Alves, Fiona Heeman, Lyduine E. Collij, Gemma Salvadó, Nelleke Tolboom, Natàlia Vilor-Tejedor, Pawel Markiewicz, Maqsood Yaqub, David Cash, Elizabeth C. Mormino, Philip S. Insel, Ronald Boellaard, Bart N. M. van Berckel, Adriaan A. Lammertsma, Frederik Barkhof, Juan Domingo Gispert
Publié dans: Alzheimer's Research & Therapy, Numéro 13/1, 2021, ISSN 1758-9193
Éditeur: BioMed Central
DOI: 10.1186/s13195-021-00819-2

Simulating the effect of cerebral blood flow changes on regional quantification of [ 18 F]flutemetamol and [ 18 F]florbetaben studies

Auteurs: Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Santiago Bullich, Juan D Gispert, Ronald Boellaard, Adriaan A Lammertsma
Publié dans: Journal of Cerebral Blood Flow & Metabolism, 2020, Page(s) 0271678X2091802, ISSN 0271-678X
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x20918029

Description of a European memory clinic cohort undergoing amyloid-PET: the AMYPAD-DPMS

Auteurs: Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N M van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Léa Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, José Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillón, Karine Fauria, Marta Felez Sanchez, Andreea Rădoi, Alexander D
Publié dans: Alzheimer’s & Dementia, 2022, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12696

The Framing of “Alzheimer’s Disease”: Differences Between Scientific and Lay Literature and Their Ethical Implications

Auteurs: Marthe Smedinga, Eline M Bunnik, Edo Richard, Maartje H N Schermer
Publié dans: The Gerontologist, 2020, ISSN 0016-9013
Éditeur: Gerontological Society of America
DOI: 10.1093/geront/gnaa113

Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients: The AMYPAD-DPMS Randomized Clinical Trial

Auteurs: Daniele Altomare, Frederik Barkhof, Camilla Caprioglio.
Publié dans: JAMA Neurology, 2023, ISSN 2168-6149
Éditeur: American Medical Association
DOI: 10.1001/jamaneurol.2023.0997

Longitudinal changes in 18F-Flutemetamol amyloid load in cognitively intact APOE4 carriers versus noncarriers: Methodological considerations

Auteurs: Emma S. Luckett, Jolien Schaeverbeke, Steffi De Meyer, Katarzyna Adamczuk, Koen Van Laere, Patrick Dupont, RikVandenberghe
Publié dans: Neuroimage: clinical, 2023, ISSN 2213-1582
Éditeur: Elsevier BV
DOI: 10.1016/j.nicl.2023.103321

The Amyloid Imaging for the Prevention of Alzheimer's Disease Consortium: A European collaboration with a global impact

Auteurs: Lyduine Collij; Gill Farrar; David Valléz García; Ilona Bader; Mahnaz Shekari; Luigi Lorenzini; Hugh Pemberton; Daniele Altomare; Sandra Pla; Mery Loor; Pawel Markiewicz; Maqsood Yaqub; Christopher Buckley; Giovanni B. Frisoni; Agneta Nordberg; Pierre Payoux; Andrew Stephens; Rossella Gismondi; Pieter Jelle Visser; Lisa Ford; Mark Schmidt; Cindy Birck; Jean Georges; Anja Mett; Zuzana Walker; Mer
Publié dans: Frontiers in Neurology, 2023, ISSN 1664-2295
Éditeur: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.1063598

Multitracer model for staging cortical amyloid deposition using PET imaging

Auteurs: Lyduine E. Collij, Fiona Heeman, Gemma Salvadó, Silvia Ingala, Daniele Altomare, Arno de Wilde, Elles Konijnenberg, Marieke van Buchem, Maqsood Yaqub, Pawel Markiewicz, Sandeep S.V. Golla, Viktor Wottschel, Alle Meije Wink, Pieter Jelle Visser, Charlotte E. Teunissen, Adriaan A. Lammertsma, Philip Scheltens, Wiesje M. van der Flier, Ronald Boellaard, Bart N.M. van Berckel, José Luis Molinuevo, J
Publié dans: Neurology, Numéro 95/11, 2020, Page(s) e1538-e1553, ISSN 0028-3878
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000010256

Uncertainty analysis of MR-PET image registration for precision neuro-PET imaging

Auteurs: Pawel J. Markiewicz, Julian C. Matthews, John Ashburner, David M. Cash, David L. Thomas, Enrico De Vita, Anna Barnes, M. Jorge Cardoso, Marc Modat, Richard Brown, Kris Thielemans, Casper da Costa-Luis, Isadora Lopes Alves, Juan Domingo Gispert, Mark E. Schmidt, Paul Marsden, Alexander Hammers, Sebastien Ourselin, Frederik Barkhof
Publié dans: NeuroImage, Numéro 232, 2021, Page(s) 117821, ISSN 1053-8119
Éditeur: Academic Press
DOI: 10.1016/j.neuroimage.2021.117821

NiftyPET: a High-throughput Software Platform for High Quantitative Accuracy and Precision PET Imaging and Analysis

Auteurs: Pawel J. Markiewicz, Matthias J. Ehrhardt, Kjell Erlandsson, Philip J. Noonan, Anna Barnes, Jonathan M. Schott, David Atkinson, Simon R. Arridge, Brian F. Hutton, Sebastien Ourselin
Publié dans: Neuroinformatics, Numéro 16/1, 2018, Page(s) 95-115, ISSN 1539-2791
Éditeur: Humana Press, Inc.
DOI: 10.1007/s12021-017-9352-y

AMYPAD Diagnostic and Patient Management Study: Rationale and design

Auteurs: Giovanni B. Frisoni, Frederik Barkhof, Daniele Altomare, Johannes Berkhof, Marina Boccardi, Elisa Canzoneri, Lyduine Collij, Alexander Drzezga, Gill Farrar, Valentina Garibotto, Rossella Gismondi, Juan-Domingo Gispert, Frank Jessen, Miia Kivipelto, Isadora Lopes Alves, José-Luis Molinuevo, Agneta Nordberg, Pierre Payoux, Craig Ritchie, Irina Savicheva, Philip Scheltens, Mark E. Schmidt, Jonathan
Publié dans: Alzheimer's & Dementia, 2018, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1016/j.jalz.2018.09.003

Secondary prevention of Alzheimer’s dementia: neuroimaging contributions

Auteurs: Mara ten Kate, Silvia Ingala, Adam J. Schwarz, Nick C. Fox, Gaël Chételat, Bart N. M. van Berckel, Michael Ewers, Christopher Foley, Juan Domingo Gispert, Derek Hill, Michael C. Irizarry, Adriaan A. Lammertsma, José Luis Molinuevo, Craig Ritchie, Philip Scheltens, Mark E. Schmidt, Pieter Jelle Visser, Adam Waldman, Joanna Wardlaw, Sven Haller, Frederik Barkhof
Publié dans: Alzheimer's Research & Therapy, Numéro 10/1, 2018, ISSN 1758-9193
Éditeur: BioMed Central
DOI: 10.1186/s13195-018-0438-z

Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18 F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods

Auteurs: Lyduine E. Collij, Elles Konijnenberg, Juhan Reimand, Mara ten Kate, Anouk den Braber, Isadora Lopes Alves, Marissa Zwan, Maqsood Yaqub, Daniëlle M.E. van Assema, Alle Meije Wink, Adriaan A. Lammertsma, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof, Bart N.M. van Berckel
Publié dans: Journal of Nuclear Medicine, Numéro 60/4, 2019, Page(s) 541-547, ISSN 0161-5505
Éditeur: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.118.211532

IDEAS becoming reality on the roadmap for biomarker validation in Alzheimer's disease

Auteurs: Giovanni B Frisoni, Isadora Lopes Alves, Frederik Barkhof
Publié dans: The Lancet Neurology, Numéro 18/6, 2019, Page(s) 519-520, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(19)30166-8

Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies

Auteurs: Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Johannes Berkhof, Juan Domingo Gispert, Santiago Bullich, Christopher Foley, Adriaan A. Lammertsma
Publié dans: EJNMMI Research, Numéro 9/1, 2019, ISSN 2191-219X
Éditeur: Springer Berlin
DOI: 10.1186/s13550-019-0499-4

The spatial-temporal ordering of amyloid pathology and opportunities for PET imaging

Auteurs: Enrico Fantoni, Lyduine Collij, Isadora Lopes Alves, Christopher Buckley, Gill Farrar
Publié dans: Journal of Nuclear Medicine, 2019, Page(s) jnumed.119.235879, ISSN 0161-5505
Éditeur: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.235879

White matter microstructure disruption in early stage amyloid pathology

Auteurs: Lyduine E. Collij, Silvia Ingala, Herwin Top, Viktor Wottschel, Kristine E. Stickney, Jori Tomassen, Elles Konijnenberg, Mara ten Kate, Carole Sudre, Isadora Lopes Alves, Maqsood M. Yaqub, Alle Meije Wink, Dennis Van ‘t Ent, Philip Scheltens, Bart N.M. Berckel, Pieter Jelle Visser, Frederik Barkhof, Anouk Den Braber
Publié dans: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Numéro 13/1, 2021, ISSN 2352-8729
Éditeur: Alzheimer's Dement
DOI: 10.1002/dad2.12124

Early detection of amyloid load using 18F-florbetaben PET

Auteurs: Santiago Bullich, Núria Roé-Vellvé, Marta Marquié, Susan M. Landau, Henryk Barthel, Victor L. Villemagne, Ángela Sanabria, Juan Pablo Tartari, Oscar Sotolongo-Grau, Vincent Doré, Norman Koglin, Andre Müller, Audrey Perrotin, Aleksandar Jovalekic, Susan De Santi, Lluís Tárraga, Andrew W. Stephens, Christopher C. Rowe, Osama Sabri, John P. Seibyl, Mercè Boada
Publié dans: Alzheimer's Research & Therapy, Numéro 13/1, 2021, ISSN 1758-9193
Éditeur: BioMed Central
DOI: 10.1186/s13195-021-00807-6

Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [11C]PiB

Auteurs: Fiona Heeman, Janine Hendriks, Isadora Lopes Alves, Nelleke Tolboom, Bart N. M. van Berckel, Maqsood Yaqub, Adriaan A. Lammertsma
Publié dans: Molecular Imaging and Biology, Numéro 23/3, 2021, Page(s) 335-339, ISSN 1536-1632
Éditeur: Elsevier BV
DOI: 10.1007/s11307-021-01606-z

Quantification of Amyloid PET for Future Clinical Use: a State-of-the-Art Review

Auteurs: Hugh G Pemberton, Lyduine E Collij, Fiona Heeman, Ariane Bollack, Mahnaz Shekari, Gemma Salvadó, Isadora Lopes Alves, David Vallez Garcia, Mark Battle, Christopher Buckley, Andrew W Stephens, Santiago Bullich, Valentina Garibotto, Frederik Barkhof, Juan Domingo Gispert, Gill Farrar
Publié dans: European Journal of Nuclear Medicine and Molecular Imaging, 2022, ISSN 1619-7070
Éditeur: Springer Verlag
DOI: 10.1007/s00259-022-05784-y

Quantitative amyloid PET in Alzheimer's disease: the AMYPAD prognostic and natural history study

Auteurs: Isadora Lopes Alves, Lyduine E. Collij, Daniele Altomare, Giovanni B. Frisoni, Laure Saint‐Aubert, Pierre Payoux, Miia Kivipelto, Frank Jessen, Alexander Drzezga, Annebet Leeuwis, Alle Meije Wink, Pieter Jelle Visser, Bart N.M. Berckel, Philip Scheltens, Katherine R. Gray, Robin Wolz, Andrew Stephens, Rossella Gismondi, Christopher Buckely, Juan Domingo Gispert, Mark Schmidt, Lisa Ford, Craig Ri
Publié dans: Alzheimer's & Dementia, Numéro 16/5, 2020, Page(s) 750-758, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1002/alz.12069