Amyloid imaging to Prevent Alzheimer’s Disease – Sofia ref.: 115952

Project Information

AMYPAD

Grant agreement ID: 115952

DOI

10.3030/115952

Project closed

EC signature date 8 November 2016

Start date 1 October 2016

End date 30 September 2022

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 27 329 288,00

EU contribution

€ 11 999 886,00

Coordinated by

STICHTING AMSTERDAM UMC
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (1)

Open-source software suite for quantification of amyloid PET images

Report and demo of an opensource software suite for amyloid PET quantification will be developed to make available to the medical and scientific communities all the methodological developments that will be developed in AMYPAD including dynamic image quantification

Publications

Peer reviewed articles (36)

Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease

Author(s): Julia Pfeil, Merle C. Hoenig, Elena Doering, Thilo van Eimeren, Alexander Drzezga, Gérard N. Bischof
Published in: Neurobiology of Aging, 2021, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2021.06.014

Ethical Frameworks for Disclosure of Alzheimer Disease Biomarkers to Research Participants: Conflicting Norms and a Nuanced Policy

Author(s): Eline M. Bunnik, Marthe Smedinga, Richard Milne, Jean Georges, Edo Richard, Maartje H. N. Schermer
Published in: Ethics and Human Research, 2022, ISSN 2578-2363
Publisher: The Hastings Center
DOI: 10.1002/eahr.500146

NiftyPAD Novel Python package for quantitative analysis of dynamic PET data

Author(s): Jieqing Jiao, Fiona Heeman, Rachael Dixon, Catriona Wimberley, Isadora Lopes Alves, Juan Domingo Gispert, Adriaan A. Lammertsma, Bart N. M. van Berckel, Casper da Costa-Luis, Pawel Markiewicz, David M. Cash, M Jorge Cardoso, Sebastién Ourselin, Maqsood Yaqub, Frederik Barkhof
Published in: Neuroinformatics, 2023, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1007/s12021-022-09616-0

Association of Alzheimer’s disease polygenic risk scores with amyloid accumulation in cognitively intact older adults

Author(s): Emma S. Luckett, Yasmina Abakkouy, Mariska Reinartz, Katarzyna Adamczuk, Jolien Schaeverbeke, Sare Verstockt, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen, Rik Vandenberghe
Published in: Alzheimer’s Research and Therapy, 2022, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1186/s13195-022-01079-4

Parametric imaging of dual-time window [18F]flutemetamol and [18F]florbetaben studies

Author(s): Fiona Heeman, Maqsood Yaqub, Janine Hendriks, Ilona Bader, Frederik Barkhof, Juan Domingo Gispert, Bart N.M. van Berckel, Isadora Lopes Alves, Adriaan A. Lammertsma
Published in: NeuroImage, Issue 234, 2021, Page(s) 117953, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2021.117953

Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias

Author(s): Gaël Chételat, Javier Arbizu, Henryk Barthel, Valentina Garibotto, Ian Law, Silvia Morbelli, Elsmarieke van de Giessen, Federica Agosta, Frederik Barkhof, David J Brooks, Maria C Carrillo, Bruno Dubois, Anders M Fjell, Giovanni B Frisoni, Oskar Hansson, Karl Herholz, Brian F Hutton, Clifford R Jack, Adriaan A Lammertsma, Susan M Landau, Satoshi Minoshima, Flavio Nobili, Agneta Nordberg, Rik Osse
Published in: The Lancet Neurology, Issue 19/11, 2020, Page(s) 951-962, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(20)30314-8

Regional associations of white matter hyperintensities and early cortical amyloid pathology

Author(s): Luigi Lorenzini, Loes T Ansems, Isadora Lopes Alves, Silvia Ingala, David Vállez García, Jori Tomassen, Carole Sudre, Gemma Salvadó, Mahnaz Shekari, Gregory Operto, Anna Brugulat-Serrat, Gonzalo Sánchez-Benavides, Mara Ten Kate, Betty Tijms, Alle Meije Wink, Henk J M M Mutsaerts, Anouk den Braber, Pieter Jelle Visser, Bart N M van Berckel, Juan Domingo Gispert, Frederik Barkhof, Lyduine E Coll
Published in: Brain, 2022, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/braincomms/fcac150

[11C]PIB amyloid quantification: effect of reference region selection

Author(s): Fiona Heeman, Janine Hendriks, Isadora Lopes Alves, Rik Ossenkoppele, Nelleke Tolboom, Bart N. M. van Berckel, Adriaan A. Lammertsma, Maqsood Yaqub
Published in: EJNMMI Research, Issue 10/1, 2020, ISSN 2191-219X
Publisher: Springer Berlin
DOI: 10.1186/s13550-020-00714-1

Should doctors offer biomarker testing to those afraid to develop Alzheimer’s dementia? – Applying the method of reflective equilibrium for a clinical dilemma

Author(s): Marthe Smedinga, Eline M Bunnik, Edo Richard, Maartje H N Schermer
Published in: Journal of bioethical inquiry, 2022, ISSN 1176-7529
Publisher: University of Otago Press
DOI: 10.1007/s11673-022-10167-x

Spatial-Temporal Patterns of Amyloid-β Accumulation: A Subtype and Stage Inference Model Analysis

Author(s): Lyduine E. Collij, Gemma Salvadó, Viktor Wottschel, Sophie E Mastenbroek, Pierre Schoenmakers, Fiona Heeman, Leon Aksman, Alle Meije Wink, Bart N.M. Berckel, Wiesje M van de Flier, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof, Sven Haller, Juan Domingo Gispert, Isadora Lopes Alves,.
Published in: Neurology, 2022, ISSN 0213-4853
Publisher: Ediciones Doyma S.A.
DOI: 10.1212/wnl.0000000000200148

Longitudinal pathways of cerebrospinal fluid and positron emission tomography biomarkers of amyloid-β positivity

Author(s): Arianna Sala, Agneta Nordberg, Elena Rodriguez-Vieitez
Published in: Molecular Psychiatry, 2020, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-020-00950-w

Impact of cereberal blood flow and amyloid load on SUVR Bias

Author(s): Fiona Heeman, Maqsood Yaqub, Janine Hendriks, Bart N. M. van Berckel, Lyduine E. Collij, Katherine R. Gray, Richard Manber, Robin Wolz, Valentina Garibotto, Catriona Wimberley, Craig Ritchie, Frederik Barkhof, Juan Domingo Gispert, David Vállez García, Isadora Lopes Alves & Adriaan A. Lammertsma on behalf of the AMYPAD Consortium
Published in: European Journal of Nuclear Medicine and Molecular Imaging, 2022, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1186/s13550-022-00898-8

Regional amyloid accumulation predicts memory decline in initially cognitively unimpaired individuals

Author(s): Lyduine E. Collij, Sophie E. Mastenbroek, Gemma Salvadó, Alle Meije Wink, Pieter Jelle Visser, Frederik Barkhof, Bart. N.M. Berckel, Isadora Lopes Alves
Published in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Issue 13/1, 2021, ISSN 2352-8729
Publisher: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
DOI: 10.1002/dad2.12216

Analysis of Psychological Symptoms Following Disclosure of Amyloid–Positron Emission Tomography Imaging Results to Adults With Subjective Cognitive Decline

Author(s): Camilla Caprioglio, Federica Ribaldi, Leonie N. C. Visser, Carolina Minguillon, Lyduine E. Collij, Oriol Grau-Rivera, Philip Zeyen, José Luis Molinuevo, Juan Domingo Gispert, Valentina Garibotto, Christian Moro, Zuzana Walker, Paul Edison, Jean-François Demonet, Frederik Barkhof, Philip Scheltens, Isadora Lopes Alves, Rossella Gismondi, Gill Farrar, Andrew W. Stephens, Frank Jessen, Giovanni B.
Published in: Jama Network, 2022, ISSN 0098-7484
Publisher: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.50921

Visual assessment of [18F]flutemetamol PET images can detect early amyloid pathology and grade its extent

Author(s): Lyduine E. Collij, Gemma Salvadó, Mahnaz Shekari, Isadora Lopes Alves, Juhan Reimand, Alle Meije Wink, Marissa Zwan, Aida Niñerola-Baizán, Andrés Perissinotti, Philip Scheltens, Milos D. Ikonomovic, Adrian P. L. Smith, Gill Farrar, José Luis Molinuevo, Frederik Barkhof, Christopher J. Buckley, Bart N. M. van Berckel, Juan Domingo Gispert
Published in: European Journal of Nuclear Medicine and Molecular Imaging, Issue 48/7, 2021, Page(s) 2169-2182, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-020-05174-2

Strategies to reduce sample sizes in Alzheimer’s disease primary and secondary prevention trials using longitudinal amyloid PET imaging

Author(s): Isadora Lopes Alves, Fiona Heeman, Lyduine E. Collij, Gemma Salvadó, Nelleke Tolboom, Natàlia Vilor-Tejedor, Pawel Markiewicz, Maqsood Yaqub, David Cash, Elizabeth C. Mormino, Philip S. Insel, Ronald Boellaard, Bart N. M. van Berckel, Adriaan A. Lammertsma, Frederik Barkhof, Juan Domingo Gispert
Published in: Alzheimer's Research & Therapy, Issue 13/1, 2021, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-021-00819-2

Simulating the effect of cerebral blood flow changes on regional quantification of [ 18 F]flutemetamol and [ 18 F]florbetaben studies

Author(s): Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Santiago Bullich, Juan D Gispert, Ronald Boellaard, Adriaan A Lammertsma
Published in: Journal of Cerebral Blood Flow & Metabolism, 2020, Page(s) 0271678X2091802, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x20918029

Description of a European memory clinic cohort undergoing amyloid-PET: the AMYPAD-DPMS

Author(s): Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N M van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Léa Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, José Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillón, Karine Fauria, Marta Felez Sanchez, Andreea Rădoi, Alexander D
Published in: Alzheimer’s & Dementia, 2022, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1002/alz.12696

The Framing of “Alzheimer’s Disease”: Differences Between Scientific and Lay Literature and Their Ethical Implications

Author(s): Marthe Smedinga, Eline M Bunnik, Edo Richard, Maartje H N Schermer
Published in: The Gerontologist, 2020, ISSN 0016-9013
Publisher: Gerontological Society of America
DOI: 10.1093/geront/gnaa113

Clinical Effect of Early vs Late Amyloid Positron Emission Tomography in Memory Clinic Patients: The AMYPAD-DPMS Randomized Clinical Trial

Author(s): Daniele Altomare, Frederik Barkhof, Camilla Caprioglio.
Published in: JAMA Neurology, 2023, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2023.0997

Longitudinal changes in 18F-Flutemetamol amyloid load in cognitively intact APOE4 carriers versus noncarriers: Methodological considerations

Author(s): Emma S. Luckett, Jolien Schaeverbeke, Steffi De Meyer, Katarzyna Adamczuk, Koen Van Laere, Patrick Dupont, RikVandenberghe
Published in: Neuroimage: clinical, 2023, ISSN 2213-1582
Publisher: Elsevier BV
DOI: 10.1016/j.nicl.2023.103321

The Amyloid Imaging for the Prevention of Alzheimer's Disease Consortium: A European collaboration with a global impact

Author(s): Lyduine Collij; Gill Farrar; David Valléz García; Ilona Bader; Mahnaz Shekari; Luigi Lorenzini; Hugh Pemberton; Daniele Altomare; Sandra Pla; Mery Loor; Pawel Markiewicz; Maqsood Yaqub; Christopher Buckley; Giovanni B. Frisoni; Agneta Nordberg; Pierre Payoux; Andrew Stephens; Rossella Gismondi; Pieter Jelle Visser; Lisa Ford; Mark Schmidt; Cindy Birck; Jean Georges; Anja Mett; Zuzana Walker; Mer
Published in: Frontiers in Neurology, 2023, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2022.1063598

Multitracer model for staging cortical amyloid deposition using PET imaging

Author(s): Lyduine E. Collij, Fiona Heeman, Gemma Salvadó, Silvia Ingala, Daniele Altomare, Arno de Wilde, Elles Konijnenberg, Marieke van Buchem, Maqsood Yaqub, Pawel Markiewicz, Sandeep S.V. Golla, Viktor Wottschel, Alle Meije Wink, Pieter Jelle Visser, Charlotte E. Teunissen, Adriaan A. Lammertsma, Philip Scheltens, Wiesje M. van der Flier, Ronald Boellaard, Bart N.M. van Berckel, José Luis Molinuevo, J
Published in: Neurology, Issue 95/11, 2020, Page(s) e1538-e1553, ISSN 0028-3878
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1212/wnl.0000000000010256

Uncertainty analysis of MR-PET image registration for precision neuro-PET imaging

Author(s): Pawel J. Markiewicz, Julian C. Matthews, John Ashburner, David M. Cash, David L. Thomas, Enrico De Vita, Anna Barnes, M. Jorge Cardoso, Marc Modat, Richard Brown, Kris Thielemans, Casper da Costa-Luis, Isadora Lopes Alves, Juan Domingo Gispert, Mark E. Schmidt, Paul Marsden, Alexander Hammers, Sebastien Ourselin, Frederik Barkhof
Published in: NeuroImage, Issue 232, 2021, Page(s) 117821, ISSN 1053-8119
Publisher: Academic Press
DOI: 10.1016/j.neuroimage.2021.117821

NiftyPET: a High-throughput Software Platform for High Quantitative Accuracy and Precision PET Imaging and Analysis

Author(s): Pawel J. Markiewicz, Matthias J. Ehrhardt, Kjell Erlandsson, Philip J. Noonan, Anna Barnes, Jonathan M. Schott, David Atkinson, Simon R. Arridge, Brian F. Hutton, Sebastien Ourselin
Published in: Neuroinformatics, Issue 16/1, 2018, Page(s) 95-115, ISSN 1539-2791
Publisher: Humana Press, Inc.
DOI: 10.1007/s12021-017-9352-y

AMYPAD Diagnostic and Patient Management Study: Rationale and design

Author(s): Giovanni B. Frisoni, Frederik Barkhof, Daniele Altomare, Johannes Berkhof, Marina Boccardi, Elisa Canzoneri, Lyduine Collij, Alexander Drzezga, Gill Farrar, Valentina Garibotto, Rossella Gismondi, Juan-Domingo Gispert, Frank Jessen, Miia Kivipelto, Isadora Lopes Alves, José-Luis Molinuevo, Agneta Nordberg, Pierre Payoux, Craig Ritchie, Irina Savicheva, Philip Scheltens, Mark E. Schmidt, Jonathan
Published in: Alzheimer's & Dementia, 2018, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1016/j.jalz.2018.09.003

Secondary prevention of Alzheimer’s dementia: neuroimaging contributions

Author(s): Mara ten Kate, Silvia Ingala, Adam J. Schwarz, Nick C. Fox, Gaël Chételat, Bart N. M. van Berckel, Michael Ewers, Christopher Foley, Juan Domingo Gispert, Derek Hill, Michael C. Irizarry, Adriaan A. Lammertsma, José Luis Molinuevo, Craig Ritchie, Philip Scheltens, Mark E. Schmidt, Pieter Jelle Visser, Adam Waldman, Joanna Wardlaw, Sven Haller, Frederik Barkhof
Published in: Alzheimer's Research & Therapy, Issue 10/1, 2018, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-018-0438-z

Assessing Amyloid Pathology in Cognitively Normal Subjects Using 18 F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods

Author(s): Lyduine E. Collij, Elles Konijnenberg, Juhan Reimand, Mara ten Kate, Anouk den Braber, Isadora Lopes Alves, Marissa Zwan, Maqsood Yaqub, Daniëlle M.E. van Assema, Alle Meije Wink, Adriaan A. Lammertsma, Philip Scheltens, Pieter Jelle Visser, Frederik Barkhof, Bart N.M. van Berckel
Published in: Journal of Nuclear Medicine, Issue 60/4, 2019, Page(s) 541-547, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.118.211532

IDEAS becoming reality on the roadmap for biomarker validation in Alzheimer's disease

Author(s): Giovanni B Frisoni, Isadora Lopes Alves, Frederik Barkhof
Published in: The Lancet Neurology, Issue 18/6, 2019, Page(s) 519-520, ISSN 1474-4422
Publisher: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(19)30166-8

Optimized dual-time-window protocols for quantitative [18F]flutemetamol and [18F]florbetaben PET studies

Author(s): Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Johannes Berkhof, Juan Domingo Gispert, Santiago Bullich, Christopher Foley, Adriaan A. Lammertsma
Published in: EJNMMI Research, Issue 9/1, 2019, ISSN 2191-219X
Publisher: Springer Berlin
DOI: 10.1186/s13550-019-0499-4

The spatial-temporal ordering of amyloid pathology and opportunities for PET imaging

Author(s): Enrico Fantoni, Lyduine Collij, Isadora Lopes Alves, Christopher Buckley, Gill Farrar
Published in: Journal of Nuclear Medicine, 2019, Page(s) jnumed.119.235879, ISSN 0161-5505
Publisher: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.119.235879

White matter microstructure disruption in early stage amyloid pathology

Author(s): Lyduine E. Collij, Silvia Ingala, Herwin Top, Viktor Wottschel, Kristine E. Stickney, Jori Tomassen, Elles Konijnenberg, Mara ten Kate, Carole Sudre, Isadora Lopes Alves, Maqsood M. Yaqub, Alle Meije Wink, Dennis Van ‘t Ent, Philip Scheltens, Bart N.M. Berckel, Pieter Jelle Visser, Frederik Barkhof, Anouk Den Braber
Published in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Issue 13/1, 2021, ISSN 2352-8729
Publisher: Alzheimer's Dement
DOI: 10.1002/dad2.12124

Early detection of amyloid load using 18F-florbetaben PET

Author(s): Santiago Bullich, Núria Roé-Vellvé, Marta Marquié, Susan M. Landau, Henryk Barthel, Victor L. Villemagne, Ángela Sanabria, Juan Pablo Tartari, Oscar Sotolongo-Grau, Vincent Doré, Norman Koglin, Andre Müller, Audrey Perrotin, Aleksandar Jovalekic, Susan De Santi, Lluís Tárraga, Andrew W. Stephens, Christopher C. Rowe, Osama Sabri, John P. Seibyl, Mercè Boada
Published in: Alzheimer's Research & Therapy, Issue 13/1, 2021, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-021-00807-6

Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [11C]PiB

Author(s): Fiona Heeman, Janine Hendriks, Isadora Lopes Alves, Nelleke Tolboom, Bart N. M. van Berckel, Maqsood Yaqub, Adriaan A. Lammertsma
Published in: Molecular Imaging and Biology, Issue 23/3, 2021, Page(s) 335-339, ISSN 1536-1632
Publisher: Elsevier BV
DOI: 10.1007/s11307-021-01606-z

Quantification of Amyloid PET for Future Clinical Use: a State-of-the-Art Review

Author(s): Hugh G Pemberton, Lyduine E Collij, Fiona Heeman, Ariane Bollack, Mahnaz Shekari, Gemma Salvadó, Isadora Lopes Alves, David Vallez Garcia, Mark Battle, Christopher Buckley, Andrew W Stephens, Santiago Bullich, Valentina Garibotto, Frederik Barkhof, Juan Domingo Gispert, Gill Farrar
Published in: European Journal of Nuclear Medicine and Molecular Imaging, 2022, ISSN 1619-7070
Publisher: Springer Verlag
DOI: 10.1007/s00259-022-05784-y

Quantitative amyloid PET in Alzheimer's disease: the AMYPAD prognostic and natural history study

Author(s): Isadora Lopes Alves, Lyduine E. Collij, Daniele Altomare, Giovanni B. Frisoni, Laure Saint‐Aubert, Pierre Payoux, Miia Kivipelto, Frank Jessen, Alexander Drzezga, Annebet Leeuwis, Alle Meije Wink, Pieter Jelle Visser, Bart N.M. Berckel, Philip Scheltens, Katherine R. Gray, Robin Wolz, Andrew Stephens, Rossella Gismondi, Christopher Buckely, Juan Domingo Gispert, Mark Schmidt, Lisa Ford, Craig Ri
Published in: Alzheimer's & Dementia, Issue 16/5, 2020, Page(s) 750-758, ISSN 1552-5260
Publisher: Elsevier BV
DOI: 10.1002/alz.12069