Obiettivo Enzymes are extremely powerful natural catalysts able to perform almost any type of chemical reaction while being mild by nature and highly specific. In fact, the delicate functioning of enzymes forms the basis of every living creature. The catalytic potential of enzymes is more and more appreciated by the industry as many industrial processes rely on these sophisticated catalysts. However, the number of reactions catalyzed by enzymes is restricted as enzymes only have evolved to catalyze reactions that are physiologically relevant. Furthermore, enzymes have adapted to the direct (cellular) environment in which they have to function (e.g. operative at ambient temperature, resilient towards proteolysis, catalytic turnover rate should fit with metabolic enzyme partners). This excludes the existence of enzymes that do not fit within boundaries set by nature. It is a great challenge to go beyond these natural boundaries and develop methodologies to design ‘unnatural’ tailor-made enzymes. Ideally it should become possible to (re)design enzymes to convert pre-defined substrates. Such designer enzymes could theoretically exhibit unsurpassed catalytic properties and, obviously, will be of significant interest for industrial biotechnology. The OXYGREEN project aims at the design and construction of novel oxygenating enzymes (designer oxygenases) for the production of compounds that can be used in medicine, food and agriculture and the development of novel powerful and generic enzyme redesign tools for this purpose. The enzymes and whole-cell biocatalysts that will be developed should catalyze the specific incorporation of oxygen to afford synthesis of bioactive compounds in a selective and clean way, with minimal side products and with no use of toxic materials. For this, generic platform technologies (novel high-throughput methodology and methods for engineering dedicated host cells) will be developed that allow effective structure-inspired directed evolution of enzyme. Campo scientifico engineering and technologyindustrial biotechnologyagricultural sciencesagriculture, forestry, and fisheriesagriculturenatural scienceschemical sciencescatalysisbiocatalysisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Parole chiave biocatalysis enzyme redesign flow cytometry high-throughput screening industrial biotechnology oxyfunctionalization oxygenase Programma(i) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Argomento(i) KBBE-2007-3-2-03 - DESIGNER ENZYMES - Improved biocatalysts for bioprocesses Invito a presentare proposte FP7-KBBE-2007-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-IP - Large-scale integrating project Coordinatore RIJKSUNIVERSITEIT GRONINGEN Contributo UE € 1 203 149,00 Indirizzo Broerstraat 5 9712CP Groningen Paesi Bassi Mostra sulla mappa Regione Noord-Nederland Groningen Overig Groningen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Jan Poutsma (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (13) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CONSTRUCTOR UNIVERSITY BREMEN GGMBH Partecipazione conclusa Germania Contributo UE € 121 989,00 Indirizzo CAMPUS RING 1 28725 Bremen Mostra sulla mappa Regione Bremen Bremen Bremen, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ronald Kieschnick (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato TECHNISCHE UNIVERSITAT DORTMUND Germania Contributo UE € 882 950,00 Indirizzo AUGUST SCHMIDT STRASSE 4 44227 Dortmund Mostra sulla mappa Regione Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Detlef Niehage (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato BIOINFOBANK INSTITUTE Polonia Contributo UE € 409 200,00 Indirizzo Limanowskiego 24/a 16 60744 POZNAN Mostra sulla mappa Tipo di attività Research Organisations Contatto amministrativo Jadwiga Borowcyk (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato TECHNISCHE UNIVERSITAET WIEN Austria Contributo UE € 363 600,00 Indirizzo KARLSPLATZ 13 1040 Wien Mostra sulla mappa Regione Ostösterreich Wien Wien Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Marko Mihovilovic (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato TECHNISCHE UNIVERSITAET GRAZ Austria Contributo UE € 832 013,00 Indirizzo RECHBAUERSTRASSE 12 8010 Graz Mostra sulla mappa Regione Südösterreich Steiermark Graz Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Anton Glieder (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITA DEGLI STUDI DI PAVIA Italia Contributo UE € 373 350,00 Indirizzo STRADA NUOVA 65 27100 Pavia Mostra sulla mappa Regione Nord-Ovest Lombardia Pavia Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Andrea Mattevi (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato DSM RESEARCH B.V. Paesi Bassi Contributo UE € 11 892,00 Indirizzo Urmonderbaan 22 6167RD GELEEN Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Johan H.M. Jansen (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato EVONIK REXIM Francia Contributo UE € 91 528,00 Indirizzo Rue de Verdun 33 80400 HAM Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Dominique Frossard (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato BIOLOG LSI FORSCHUNGS- UND BETEILIGUNGS-GMBH Germania Contributo UE € 258 400,00 Indirizzo FLUGHAFENDAMM 9A 28199 BREMEN Mostra sulla mappa Regione Bremen Bremen Bremen, Kreisfreie Stadt Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Hans-Gottfried Genieser (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato ENZYSCREEN Paesi Bassi Contributo UE € 98 400,00 Indirizzo Wassenaarseweg 2333 AL LEIDEN Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Wouter Duetz (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato DECHEMA GESELLSCHAFT FUR CHEMISCHETECHNIK UND BIOTECHNOLOGIE Germania Contributo UE € 250 140,00 Indirizzo THEODOR HEUSS ALLEE 25 60486 Frankfurt Mostra sulla mappa Regione Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Tipo di attività Research Organisations Contatto amministrativo Jens Schrader (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Germania Contributo UE € 578 530,00 Indirizzo TEMPLERGRABEN 55 52062 Aachen Mostra sulla mappa Regione Nordrhein-Westfalen Köln Städteregion Aachen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Ernst Schmachtenberg (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato DSM INNOVATIVE SYNTHESIS BV Paesi Bassi Contributo UE € 68 108,00 Indirizzo POSTSTRAAT 1 6135 KR SITTARD Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Ine Weijer Van De (Mrs.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato