Objectif Future breakthroughs in the understanding of fundamental biological processes causing major diseases are expected from the development of miniaturized probes or microscopes able to detect and identify a single or a small number of molecules. The SingleMoleculeDetection (SMD) proposal will develop a unique device able to perform simultaneously and in a dynamic way force and spectroscopic measurements. We will design and fabricate novel devices for the generation of plasmon polaritons as well as combine photonic crystals and plasmonic nanolenses. These new devices will be able to detect few/single molecules through Raman, InfraRed and Terahertz (THz) signals and in combination with Atomic Force Microscopy and Optical Tweezer force spectroscopy with a spatial resolution in the sub-10 nm for Raman and IR and sub-100 nm for the THz region. The complete characterization of single unknown molecule will be demonstrated through: i- investigations on the chemical and physical properties of membrane receptors, such as rhodopsin, odorant receptors and ionic channels; ii- identification of new molecules involved in cancer development and metastasis. The new devices will allow the acquisition of THz images and we will explore the possibilities of this new spectral region for biomedical scanning. The SMD proposal is based on an original idea of the coordinator, prof. E. di Fabrizio and will be exploited thanks to the complementary expertise present in the different sites and to a tight coordination between the various groups. The design, fabrication and testing will be performed at UMG, TASC and CBM Integration in a single instrument will be carried out at TASC, CBM, IIT Nanotec, RUB. Validation activities will be performed by all the partners taking advantage of the world leading expertise of the TUDO and the STRATH- AC in spectroscopy of natural and artificial biological systems. The SME NANOTEC and CBM will provide the commercial exploitation of the obtained results. Champ scientifique natural sciencesphysical sciencesopticsmicroscopymedical and health sciencesclinical medicineoncologynatural sciencesphysical sciencesopticsspectroscopy Mots‑clés Atomic Force Microscope Molecule Manipulation Optical Tweezer Photonic Crystal Plasmonics Raman Spectroscopy Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Thème(s) NMP-2008-1.1-1 - Converging sciences and technologies (nano, bio, info and/or cogni) Appel à propositions FP7-NMP-2008-SMALL-2 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur CONSORZIO PER IL CENTRO DI BIOMEDICINA MOLECOLARE SCARL Contribution de l’UE € 896 136,40 Adresse STRADA STATALE 14 KM 163 5 BASOVIZZA 34149 Trieste Italie Voir sur la carte Région Nord-Est Friuli-Venezia Giulia Trieste Type d’activité Research Organisations Contact administratif Anna Lucia Bellina (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (7) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire UNIVERSITA DEGLI STUDI MAGNA GRAECIA DI CATANZARO Italie Contribution de l’UE € 271 466,00 Adresse VIALE EUROPA LOCALITA GERMANETO 88100 Catanzaro Voir sur la carte Région Sud Calabria Catanzaro Type d’activité Higher or Secondary Education Establishments Contact administratif Roberto Sigilli (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée RUHR-UNIVERSITAET BOCHUM Allemagne Contribution de l’UE € 475 978,00 Adresse UNIVERSITAETSSTRASSE 150 44801 Bochum Voir sur la carte Région Nordrhein-Westfalen Arnsberg Bochum, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Martina Havenith (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée TECHNISCHE UNIVERSITAT DORTMUND Allemagne Contribution de l’UE € 429 850,00 Adresse AUGUST SCHMIDT STRASSE 4 44227 Dortmund Voir sur la carte Région Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Type d’activité Higher or Secondary Education Establishments Contact administratif Daniel Schneider (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITY OF STRATHCLYDE Royaume-Uni Contribution de l’UE € 499 232,00 Adresse Richmond Street 16 G1 1XQ Glasgow Voir sur la carte Région Scotland West Central Scotland Glasgow City Type d’activité Higher or Secondary Education Establishments Contact administratif Martin Gregory (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée CONSIGLIO NAZIONALE DELLE RICERCHE Italie Contribution de l’UE € 267 448,00 Adresse PIAZZALE ALDO MORO 7 00185 Roma Voir sur la carte Région Centro (IT) Lazio Roma Type d’activité Research Organisations Contact administratif Martina Centazzo (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Nanotec Electronica SL Espagne Contribution de l’UE € 315 500,00 Adresse RONDA DE PONIENTE 12 2 C 28760 TRES CANTOS MADRID Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Leonor Badorrey (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Italie Contribution de l’UE € 265 889,60 Adresse VIA MOREGO 30 16163 Genova Voir sur la carte Région Nord-Ovest Liguria Genova Type d’activité Research Organisations Contact administratif Gabriele Ballero (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée
