Objetivo Future breakthroughs in the understanding of fundamental biological processes causing major diseases are expected from the development of miniaturized probes or microscopes able to detect and identify a single or a small number of molecules. The SingleMoleculeDetection (SMD) proposal will develop a unique device able to perform simultaneously and in a dynamic way force and spectroscopic measurements. We will design and fabricate novel devices for the generation of plasmon polaritons as well as combine photonic crystals and plasmonic nanolenses. These new devices will be able to detect few/single molecules through Raman, InfraRed and Terahertz (THz) signals and in combination with Atomic Force Microscopy and Optical Tweezer force spectroscopy with a spatial resolution in the sub-10 nm for Raman and IR and sub-100 nm for the THz region. The complete characterization of single unknown molecule will be demonstrated through: i- investigations on the chemical and physical properties of membrane receptors, such as rhodopsin, odorant receptors and ionic channels; ii- identification of new molecules involved in cancer development and metastasis. The new devices will allow the acquisition of THz images and we will explore the possibilities of this new spectral region for biomedical scanning. The SMD proposal is based on an original idea of the coordinator, prof. E. di Fabrizio and will be exploited thanks to the complementary expertise present in the different sites and to a tight coordination between the various groups. The design, fabrication and testing will be performed at UMG, TASC and CBM Integration in a single instrument will be carried out at TASC, CBM, IIT Nanotec, RUB. Validation activities will be performed by all the partners taking advantage of the world leading expertise of the TUDO and the STRATH- AC in spectroscopy of natural and artificial biological systems. The SME NANOTEC and CBM will provide the commercial exploitation of the obtained results. Ámbito científico natural sciencesphysical sciencesopticsmicroscopymedical and health sciencesclinical medicineoncologynatural sciencesphysical sciencesopticsspectroscopy Palabras clave Atomic Force Microscope Molecule Manipulation Optical Tweezer Photonic Crystal Plasmonics Raman Spectroscopy Programa(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Tema(s) NMP-2008-1.1-1 - Converging sciences and technologies (nano, bio, info and/or cogni) Convocatoria de propuestas FP7-NMP-2008-SMALL-2 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador CONSORZIO PER IL CENTRO DI BIOMEDICINA MOLECOLARE SCARL Aportación de la UE € 896 136,40 Dirección STRADA STATALE 14 KM 163 5 BASOVIZZA 34149 Trieste Italia Ver en el mapa Región Nord-Est Friuli-Venezia Giulia Trieste Tipo de actividad Research Organisations Contacto administrativo Anna Lucia Bellina (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (7) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo UNIVERSITA DEGLI STUDI MAGNA GRAECIA DI CATANZARO Italia Aportación de la UE € 271 466,00 Dirección VIALE EUROPA LOCALITA GERMANETO 88100 Catanzaro Ver en el mapa Región Sud Calabria Catanzaro Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Roberto Sigilli (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos RUHR-UNIVERSITAET BOCHUM Alemania Aportación de la UE € 475 978,00 Dirección UNIVERSITAETSSTRASSE 150 44801 Bochum Ver en el mapa Región Nordrhein-Westfalen Arnsberg Bochum, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Martina Havenith (Prof.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos TECHNISCHE UNIVERSITAT DORTMUND Alemania Aportación de la UE € 429 850,00 Dirección AUGUST SCHMIDT STRASSE 4 44227 Dortmund Ver en el mapa Región Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Daniel Schneider (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos UNIVERSITY OF STRATHCLYDE Reino Unido Aportación de la UE € 499 232,00 Dirección Richmond Street 16 G1 1XQ Glasgow Ver en el mapa Región Scotland West Central Scotland Glasgow City Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Martin Gregory (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos CONSIGLIO NAZIONALE DELLE RICERCHE Italia Aportación de la UE € 267 448,00 Dirección PIAZZALE ALDO MORO 7 00185 Roma Ver en el mapa Región Centro (IT) Lazio Roma Tipo de actividad Research Organisations Contacto administrativo Martina Centazzo (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Nanotec Electronica SL España Aportación de la UE € 315 500,00 Dirección RONDA DE PONIENTE 12 2 C 28760 TRES CANTOS MADRID Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Leonor Badorrey (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA Italia Aportación de la UE € 265 889,60 Dirección VIA MOREGO 30 16163 Genova Ver en el mapa Región Nord-Ovest Liguria Genova Tipo de actividad Research Organisations Contacto administrativo Gabriele Ballero (Mr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos