Objectif Mitochondria are highly dynamic organelles that continuously move, divide and fuse in a highly regulated fashion. The balance between the opposing processes of mitochondrial fusion and fission is controlled by a growing family of “mitochondria-shaping” proteins. Evidence is accumulating on the role of these proteins in several functions, from apoptosis to Ca2+ signaling, to morphogenesis of dendritic spines and synapses, to regulation of migration of leukocytes. The knowledge of the regulation of mitochondrial dynamics, as well as its impact on tissue development and homeostasis is currently limited. This project hypothesizes that changes in mitochondrial morphology are crucial events in determining migration and development of T cells in the thymus. We will capitalize on the mouse models available in the host laboratory to (i) address whether mitochondrial dynamics regulates motility of lymphocytes in intact mouse thymic lobes; (ii) understand whether pro-fusion or pro-fission proteins regulate T cell development; (iii) dissect the role of fusion vs. antiapoptotic effect of pro-fusion protein in T cell migration and development. Our project is expected to clarify the role of mitochondrial dynamics in a complex immunological scenario like thymic development. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinephysiologyhomeostasis Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Thème(s) FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development" Appel à propositions FP7-PEOPLE-IEF-2008 Voir d’autres projets de cet appel Régime de financement MC-IEF - Intra-European Fellowships (IEF) Coordinateur UNIVERSITE DE GENEVE Contribution de l’UE € 180 801,44 Adresse RUE DU GENERAL DUFOUR 24 1211 Geneve Suisse Voir sur la carte Région Schweiz/Suisse/Svizzera Région lémanique Genève Type d’activité Higher or Secondary Education Establishments Contact administratif Luca Scorrano (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée