Role of mitochondria-shaping proteins in T cell development and migration in vivo

Projektinformationen

DYNA-MITO IN THYMUS

ID Finanzhilfevereinbarung: 235595

Abgeschlossenes Projekt

Startdatum 1 Januar 2010

Enddatum 31 Dezember 2011

Finanziert unter

• Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Gesamtkosten € 180 801,44

EU-Beitrag € 180 801,44

Koordiniert durch

UNIVERSITE DE GENEVE
Switzerland

Ziel

Mitochondria are highly dynamic organelles that continuously move, divide and fuse in a highly regulated fashion. The balance between the opposing processes of mitochondrial fusion and fission is controlled by a growing family of “mitochondria-shaping” proteins. Evidence is accumulating on the role of these proteins in several functions, from apoptosis to Ca2+ signaling, to morphogenesis of dendritic spines and synapses, to regulation of migration of leukocytes. The knowledge of the regulation of mitochondrial dynamics, as well as its impact on tissue development and homeostasis is currently limited. This project hypothesizes that changes in mitochondrial morphology are crucial events in determining migration and development of T cells in the thymus. We will capitalize on the mouse models available in the host laboratory to (i) address whether mitochondrial dynamics regulates motility of lymphocytes in intact mouse thymic lobes; (ii) understand whether pro-fusion or pro-fission proteins regulate T cell development; (iii) dissect the role of fusion vs. antiapoptotic effect of pro-fusion protein in T cell migration and development. Our project is expected to clarify the role of mitochondrial dynamics in a complex immunological scenario like thymic development.

Wissenschaftliches Gebiet

• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• medical and health sciences › basic medicine › physiology › homeostasis

Programm/Programme

• FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)

Thema/Themen

• FP7-PEOPLE-IEF-2008 - Marie Curie Action: "Intra-European Fellowships for Career Development"

Aufforderung zur Vorschlagseinreichung

FP7-PEOPLE-IEF-2008
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

MC-IEF - Intra-European Fellowships (IEF)

Koordinator

UNIVERSITE DE GENEVE

Kontakt Verwaltung

Luca Scorrano (Prof.)

• EU-Beitrag: € 180 801,44
• Adresse: RUE DU GENERAL DUFOUR 24 ; 1211 Geneve ; Schweiz
• Region: Schweiz/Suisse/Svizzera › Région lémanique › Genève
• Aktivitätstyp: Higher or Secondary Education Establishments
• Gesamtkosten: Keine Daten