Objective Current interventional treatment of acute myocardial infarction (AMI) focused on re-establishing cardiac reperfusion has significantly improved clinical outcome by reducing infarct size and mortality due to cardiac ischemia.It is now recognized that events triggered at reperfusion also result in cell death and may account for as much as 50% of the infarct volume, this being termed ischemia-reperfusion injury (IRI). Mitochondrial permeability transition pore (mPTP) opening appears to be a responsible for IRI and a recent small clinical trial with cyclosporine A shows that it is a feasible target for the development of new therapies to treat it. Since total infarct size is a major determinant of a patients risk to develop heart failure, treating IRI is expected to further reduce morbidity, mortality and the need for regenerative medicine following cardiac ischemia. By harnessing a multi-disciplinary consortium of clinical and basic scientists along with four SMEs, MitoCare brings state-of-the art expertise together to 1) better understand IRI pathophysiology and factors directly or indirectly influencing patient’s recovery or response to treatment; 2) investigate the translational usefulness of preclinical models; and 3) compare selected treatments. These objectives will be reached through the following work plan: A) a medium-scale phase II clinical study will evaluate the efficacy of a novel complementary therapy to PCI, the new mPTP modulator TRO40303, while at the same time 1) perform extensive sampling from subjects in the study for analysis of standard and emerging biomarkers; 2) identify confounding factors influencing patients’ outcomes. B) Parallel investigations in preclinical in vitro and in vivo AMI models. C) Statistical analysis of data from clinical and preclinical studies, to identify better diagnostic and prognostic endpoints in man and assess predictive utility of preclinical models. Fields of science social sciencessociologydemographymortalitymedical and health sciencesbasic medicinephysiologypathophysiologymedical and health sciencesclinical medicinecardiology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.2.4.2-2 - New approaches to reduce ischemic damage to the heart. FP7-HEALTH-2010-single-stage Call for proposal FP7-HEALTH-2010-single-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator TROPHOS SA EU contribution € 2 199 952,00 Address PARC SCIENTIFIQUE LUMINY CASE 931 13288 MARSEILLE CEDEX 9 France See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Julien Veys (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (16) Sort alphabetically Sort by EU Contribution Expand all Collapse all ASSISTANCE PUBLIQUE HOPITAUX DE PARIS France EU contribution € 536 624,00 Address 55 BOULEVARD DIDEROT 75012 Paris See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Research Organisations Administrative Contact Anne Skrobot (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 278 988,00 Address RUE DE TOLBIAC 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Didier Lemoine (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITETET I BERGEN Norway EU contribution € 212 512,00 Address MUSEPLASSEN 1 5020 Bergen See on map Region Norge Vestlandet Vestland Activity type Higher or Secondary Education Establishments Administrative Contact Inger Gjesdahl (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data REGION NORDJYLLAND (NORTH DENMARK REGION) Denmark EU contribution € 258 276,00 Address Niels Bohrs Vej 30 9220 Aalborg See on map Region Danmark Nordjylland Nordjylland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Svend Eggert Jensen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MAX IV Laboratory, Lund University Sweden EU contribution € 413 120,00 Address Paradisgatan 5c 22100 LUND See on map Region Södra Sverige Sydsverige Skåne län Activity type Higher or Secondary Education Establishments Administrative Contact David Erlinge (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data REGION HOVEDSTADEN Denmark EU contribution € 35 184,00 Address KONGENS VAENGE 2 3400 Hillerod See on map Region Danmark Hovedstaden Nordsjælland Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Skov Jensen Jan (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KAROLINSKA INSTITUTET Participation ended Sweden EU contribution € 10 068,11 Address Nobels Vag 5 17177 Stockholm See on map Region Östra Sverige Stockholm Stockholms län Activity type Higher or Secondary Education Establishments Administrative Contact Caroline Hamilton (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY OF BRISTOL United Kingdom EU contribution € 272 064,00 Address BEACON HOUSE QUEENS ROAD BS8 1QU Bristol See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Activity type Higher or Secondary Education Establishments Administrative Contact Johanna Rule (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FIRALIS France EU contribution € 778 321,00 Address RUE DU FORT 35 68330 Huningue See on map Region Grand Est Alsace Haut-Rhin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Fuat Firat (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data GOETEBORGS UNIVERSITET Participation ended Sweden EU contribution No data Address VASAPARKEN 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Administrative Contact Emilia Rung (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data IMACOR AB Sweden EU contribution € 299 460,00 Address REKTORSVAGEN 16 55467 LUND See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Hakan Arheden (Prof.) Links Contact the organisation Opens in new window Total cost No data MOBILE HEALTH SAS France EU contribution € 113 525,89 Address Avenue KLEBER 112 75116 PARIS See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Gilles Sonou (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data OSLO UNIVERSITETSSYKEHUS HF Norway EU contribution € 201 530,00 Address KIRKEVEIEN 166 TARNBYGGET 0450 Oslo See on map Region Norge Oslo og Viken Oslo Activity type Higher or Secondary Education Establishments Administrative Contact Dag Kvale (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ODENSE UNIVERSITETSHOSPITAL Denmark EU contribution € 206 608,00 Address Sdr. Boulevard 29 5000 ODENSE See on map Activity type Research Organisations Administrative Contact Henrik Steen Hansen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HELSE STAVANGER HF Norway EU contribution € 101 052,00 Address GERD RAGNA BLOCH THORSENS GATE 8 4011 Stavanger See on map Region Norge Vestlandet Rogaland Activity type Other Administrative Contact Torbjørn Aarsland (Mr.) Links Contact the organisation Opens in new window Total cost No data CENTRE HOSPITALIER REGIONAL DE MARSEILLE ASSISTANCE PUBLIQUE-HOPITAUX MARSEILLE France EU contribution € 73 674,00 Address RUE BROCHIER 80 13354 Marseille Cedex 20 See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Research Organisations Administrative Contact Isabelle Amabile (Ms.) Links Contact the organisation Opens in new window Total cost No data
