Objectif While early detection of breast cancer by screening appears effective, many women derive little or no benefit from screening, due to the way it is currently organized: as a one-size-fits all approach irrespective of personalised risk factors. It is known, however, that some women are at a much higher risk of getting the disease than others, and that mammography is unsuitable for cancer detection in women with dense breasts. The aim of this project is to develop personalised methods to tailor breast cancer screening to the individual needs of the woman. We will propose methods to stratify women at the highest risk to MRI; those with intermediate risk and/or dense breasts to follow-on ultrasound. A risk model will be developed that includes both breast cancer risk and the risk of missing cancers in mammograms. In this model, breast density plays a key role, as one of the largest known risk factors and the factor making mammograms ineffective. Two SMEs focusing on breast density are involved, where academic partners bring unique databases with over 80,000 screening mammograms and associated risk profiles. These are essential for model development, and subsequently for the development of products that benefit all women. Personalised screening is only economically feasible if it is based upon cost-effective strategies. While current methods in breast MRI imaging and breast ultrasound are promising, more efficient protocols must be developed to use these modalities routinely in screening. With leading SMEs and clinical partners, screening procedures will be optimized by developing automated image analysis tools to guide workflow and quality assurance. More efficient MRI protocols will be investigated to reduce time and cost, while the use of novel MRI imaging sequences without intravenous contrast will be explored. Cost-effectiveness of the stratification models will be assessed by combining the risk model with cost and effectiveness of alternative screening strategies. Champ scientifique natural sciencescomputer and information sciencesdatabasesmedical and health sciencesclinical medicineoncologybreast cancernatural sciencesphysical sciencesacousticsultrasound Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2012.1.2-1 - Development of technologies with a view to patient group stratification for personalised medicine applications Appel à propositions FP7-HEALTH-2012-INNOVATION-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur STICHTING RADBOUD UNIVERSITEIT Contribution de l’UE € 1 048 127,20 Adresse HOUTLAAN 4 6525 XZ Nijmegen Pays-Bas Voir sur la carte Région Oost-Nederland Gelderland Arnhem/Nijmegen Type d’activité Higher or Secondary Education Establishments Contact administratif Nico Karssemeijer (Prof.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (9) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire MEVIS MEDICAL SOLUTIONS AG Allemagne Contribution de l’UE € 796 125,60 Adresse CAROLINE-HERSCHEL-STRASSE 1 28359 BREMEN Voir sur la carte Région Bremen Bremen Bremen, Kreisfreie Stadt Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Thomas Pross (Mr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée MATAKINA UK LIMITED Royaume-Uni Contribution de l’UE € 631 680,75 Adresse WALNUT TREE CLOSE 1 CB6 2SQ ELY Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Ralph Highnam (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée BIOMEDIQ AS Danemark Contribution de l’UE € 700 086,80 Adresse FRUEBJERGVEJ 3 2100 KOBENHAVN Voir sur la carte Région Danmark Hovedstaden Byen København Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Camilla Jørgensen (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée MEDIRI GMBH Allemagne Contribution de l’UE € 404 360,00 Adresse EPPELHEIMER STR 13 69115 Heidelberg Voir sur la carte Région Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Johannes Gregori (Dr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Allemagne Contribution de l’UE € 566 798,75 Adresse HANSASTRASSE 27C 80686 Munchen Voir sur la carte Région Bayern Oberbayern München, Kreisfreie Stadt Type d’activité Research Organisations Contact administratif Christoph Schulte (Mr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée THE UNIVERSITY OF MANCHESTER Royaume-Uni Contribution de l’UE € 687 413,60 Adresse OXFORD ROAD M13 9PL Manchester Voir sur la carte Région North West (England) Greater Manchester Manchester Type d’activité Higher or Secondary Education Establishments Contact administratif Katherine Boylan (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITAT DE GIRONA Espagne Contribution de l’UE € 355 290,40 Adresse PLACA SANT DOMENEC 3 17004 Girona Voir sur la carte Région Este Cataluña Girona Type d’activité Higher or Secondary Education Establishments Contact administratif Montserrat Estopà (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée UNIVERSITAIR MEDISCH CENTRUM UTRECHT Pays-Bas Contribution de l’UE € 263 095,20 Adresse HEIDELBERGLAAN 100 3584 CX Utrecht Voir sur la carte Région West-Nederland Utrecht Utrecht Type d’activité Higher or Secondary Education Establishments Contact administratif Carla H Van Gils (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée INSTITUT JULES BORDET ASBL Belgique Contribution de l’UE € 155 565,20 Adresse RUE MEYLEMEERSCH, 90 1070 Anderlecht Voir sur la carte Région Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Type d’activité Higher or Secondary Education Establishments Contact administratif Marielle Sautois (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée