Obiettivo While early detection of breast cancer by screening appears effective, many women derive little or no benefit from screening, due to the way it is currently organized: as a one-size-fits all approach irrespective of personalised risk factors. It is known, however, that some women are at a much higher risk of getting the disease than others, and that mammography is unsuitable for cancer detection in women with dense breasts. The aim of this project is to develop personalised methods to tailor breast cancer screening to the individual needs of the woman. We will propose methods to stratify women at the highest risk to MRI; those with intermediate risk and/or dense breasts to follow-on ultrasound. A risk model will be developed that includes both breast cancer risk and the risk of missing cancers in mammograms. In this model, breast density plays a key role, as one of the largest known risk factors and the factor making mammograms ineffective. Two SMEs focusing on breast density are involved, where academic partners bring unique databases with over 80,000 screening mammograms and associated risk profiles. These are essential for model development, and subsequently for the development of products that benefit all women. Personalised screening is only economically feasible if it is based upon cost-effective strategies. While current methods in breast MRI imaging and breast ultrasound are promising, more efficient protocols must be developed to use these modalities routinely in screening. With leading SMEs and clinical partners, screening procedures will be optimized by developing automated image analysis tools to guide workflow and quality assurance. More efficient MRI protocols will be investigated to reduce time and cost, while the use of novel MRI imaging sequences without intravenous contrast will be explored. Cost-effectiveness of the stratification models will be assessed by combining the risk model with cost and effectiveness of alternative screening strategies. Campo scientifico natural sciencescomputer and information sciencesdatabasesmedical and health sciencesclinical medicineoncologybreast cancernatural sciencesphysical sciencesacousticsultrasound Programma(i) FP7-HEALTH - Specific Programme "Cooperation": Health Argomento(i) HEALTH.2012.1.2-1 - Development of technologies with a view to patient group stratification for personalised medicine applications Invito a presentare proposte FP7-HEALTH-2012-INNOVATION-1 Vedi altri progetti per questo bando Meccanismo di finanziamento CP-FP - Small or medium-scale focused research project Coordinatore STICHTING RADBOUD UNIVERSITEIT Contributo UE € 1 048 127,20 Indirizzo HOUTLAAN 4 6525 XZ Nijmegen Paesi Bassi Mostra sulla mappa Regione Oost-Nederland Gelderland Arnhem/Nijmegen Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Nico Karssemeijer (Prof.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato Partecipanti (9) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto MEVIS MEDICAL SOLUTIONS AG Germania Contributo UE € 796 125,60 Indirizzo CAROLINE-HERSCHEL-STRASSE 1 28359 BREMEN Mostra sulla mappa Regione Bremen Bremen Bremen, Kreisfreie Stadt Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Thomas Pross (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato MATAKINA UK LIMITED Regno Unito Contributo UE € 631 680,75 Indirizzo WALNUT TREE CLOSE 1 CB6 2SQ ELY Mostra sulla mappa Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Ralph Highnam (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato BIOMEDIQ AS Danimarca Contributo UE € 700 086,80 Indirizzo FRUEBJERGVEJ 3 2100 KOBENHAVN Mostra sulla mappa Regione Danmark Hovedstaden Byen København Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Camilla Jørgensen (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato MEDIRI GMBH Germania Contributo UE € 404 360,00 Indirizzo EPPELHEIMER STR 13 69115 Heidelberg Mostra sulla mappa Regione Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Tipo di attività Private for-profit entities (excluding Higher or Secondary Education Establishments) Contatto amministrativo Johannes Gregori (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Costo totale Nessun dato FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germania Contributo UE € 566 798,75 Indirizzo HANSASTRASSE 27C 80686 Munchen Mostra sulla mappa Regione Bayern Oberbayern München, Kreisfreie Stadt Tipo di attività Research Organisations Contatto amministrativo Christoph Schulte (Mr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato THE UNIVERSITY OF MANCHESTER Regno Unito Contributo UE € 687 413,60 Indirizzo OXFORD ROAD M13 9PL Manchester Mostra sulla mappa Regione North West (England) Greater Manchester Manchester Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Katherine Boylan (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAT DE GIRONA Spagna Contributo UE € 355 290,40 Indirizzo PLACA SANT DOMENEC 3 17004 Girona Mostra sulla mappa Regione Este Cataluña Girona Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Montserrat Estopà (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato UNIVERSITAIR MEDISCH CENTRUM UTRECHT Paesi Bassi Contributo UE € 263 095,20 Indirizzo HEIDELBERGLAAN 100 3584 CX Utrecht Mostra sulla mappa Regione West-Nederland Utrecht Utrecht Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Carla H Van Gils (Dr.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato INSTITUT JULES BORDET ASBL Belgio Contributo UE € 155 565,20 Indirizzo RUE MEYLEMEERSCH, 90 1070 Anderlecht Mostra sulla mappa Regione Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Tipo di attività Higher or Secondary Education Establishments Contatto amministrativo Marielle Sautois (Ms.) Collegamenti Contatta l’organizzazione Opens in new window Sito web Opens in new window Costo totale Nessun dato