Obiettivo The MuNanoVac STREP project will assess a new vaccine strategy to prevent HIV-1 infection based on a primo-vaccination using a biodegradable synthetic colloidal carrier made of poly-lactic acid (PLA) nanoparticles covered with adsorbed antigens. The aim is to demonstrate that PLA nanoparticles are a perfect mucosal vaccine vehicle, immunogenic for both arms of immunity, adaptable to many types of antigens, easy and simple to produce. Such nanoparticle-based vaccine carriers will allow targeting dentritic cells or transporting the vaccine through skin or mucosal epithelial barriers. To amplify the mucosal immune response, the project will investigate the potential use of immuno-modulator molecules associated with different immunization routes and schedules. Six main technical activities will be conducted in the project: 1) Elaborating a standardized formulation process of PLA nanoparticles with selected HIV-1 antigens, gag and trimeric gp140 2) Identifying the best adjuvant among four candidates to potentiate the mucosal immune responses induced by PLA formulations 3) Optimizing the uptake of nanoparticles by mucosa or skin and the orientation of the immune response 4) Defining the best immunization routes and schedules of nanoparticle formulation in presence or absence of immuno-modulators for immune responses 5) Testing safety and mucosal immunity of the two best combinations in rabbits and 6) Evaluating the vaccine strategy efficacy studies with rectal and vaginal challenge routes in non human primates. Additional activities will include dissemination and exploitation of results, IPR and societal issues. The MuNanoVac project will contribute to advancing a promising vaccine approach for HIV, that could prove versatile enough for application to other poverty-related diseases e.g. Tuberculosis. With the proposed vaccine candidate, the project gives Europe a tremendous opportunity to gain leadership in the use of biodegradable nanoparticles for vaccine carriers. Campo scientifico engineering and technologyindustrial biotechnologybiomaterialsbioplasticspolylactic acidmedical and health sciencesbasic medicineimmunologyimmunisationmedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesengineering and technologynanotechnologynano-materials Programma(i) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) LSH-2005-2.3.0-10 - SME-driven innovations for poverty-related diseases Invito a presentare proposte FP6-2005-LIFESCIHEALTH-7 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore PHUSIS Contributo UE Nessun dato Indirizzo Espace Randon 58 route du Rivet SAINT ISMIER Francia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (7) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE Francia Contributo UE Nessun dato Indirizzo Rue Michel-Ange 3 PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ST GEORGE'S HOSPITAL MEDICAL SCHOOL Regno Unito Contributo UE Nessun dato Indirizzo Cranmer Terrace LONDON Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato PALACKY UNIVERSITY IN OLOMOUC Cechia Contributo UE Nessun dato Indirizzo Krizkovského 8 OLOMOUC Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN Germania Contributo UE Nessun dato Indirizzo Schumannstraße 20/21 BERLIN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato COMMISSARIAT À L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Francia Contributo UE Nessun dato Indirizzo 31-33 rue de la Fédération PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato HOSPITAL CLÍNIC I PROVINCIAL DE BARCELONA Spagna Contributo UE Nessun dato Indirizzo Villarroel, 170 BARCELONA Mostra sulla mappa Costo totale Nessun dato UNIVERSITÉ PIERRE ET MARIE CURIE - PARIS 6 Francia Contributo UE Nessun dato Indirizzo 4 place de jussieu PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato