Obiettivo Pneumonia is one of the three most important causes of childhood deaths worldwide. Routine zinc administration to children in developing countries reduces the incidence of pneumonia and diarrhea. Thus, identification of realistic means to improve zinc nutriture in these children is warranted. Zinc has to be ingested every day, increasing the zinc intake of young infants, who are supposed to be exclusively breastfed is accordingly difficult. Therapeutic oral zinc administration during an ongoing infection, however, is incompatible with current breastfeeding recommendations and might be a feasible alternative to counteract the consequences of poor zinc nutriture. The benefits of therapeutic oral zinc given to children with diarrhea are well documented but the therapeutic effect of zinc when given during pneumonia or other severe bacterial illnesses has yet to be demonstrated. Furthermore, even short courses of zinc have been shown to reduce childhood morbidity for up to six months and may become an alternative to long/term zinc supplementation. We wish to assess the efficacy of oral zinc given during pneumonia in hospitalized and in non/hospitalized children 2 to 35 months of age and during severe bacterial illness in children less than 2 months of age on the severity of the enrollment episode and on subsequent morbidity and nutritional status for six months. Thus, the objective of the proposed project is to identify a community based and health facility based approach to improve zinc nutriture and to reduce the consequences of zinc deficiency in children with pneumonia or severe bacterial illness. If proven to be as effective as oral zinc supplementation during acute diarrhea, this new therapeutic micronutrient intervention strategy could rapidly be translated into a cost/effective and feasible primary care/based intervention to enhance child nutrition and survival from pneumonia or other severe bacterial illnesses in developing countries. Campo scientifico medical and health sciencesclinical medicinepneumologysocial sciencessociologydemographymortalitynatural sciencesbiological sciencesmicrobiologybacteriologynatural scienceschemical sciencesinorganic chemistrytransition metalsmedical and health scienceshealth sciencesnutrition Parole chiave children clinical trials community hospital pneumonia prevention therapeutic zinc Programma(i) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Argomento(i) INCO - Specific measures in support of international co-operation INCO-2003-A1.2 - Healthcare systems and management Invito a presentare proposte FP6-2002-INCO-DEV-1 Vedi altri progetti per questo bando Meccanismo di finanziamento STREP - Specific Targeted Research Project Coordinatore UNIVERSITETET I BERGEN Contributo UE Nessun dato Indirizzo Muséplass 1 BERGEN Norvegia Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato Partecipanti (5) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto TRIBHUVAN UNIVERSITY Nepal Contributo UE Nessun dato Indirizzo Kirtipur 2533 KATHMANDU Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato STATENS SERUM INSTITUT Danimarca Contributo UE Nessun dato Indirizzo Artillerivej 5 COPENHAGEN Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato ALL INDIA INSTITUTE OF MEDICAL SCIENCES India Contributo UE Nessun dato Indirizzo Ansari Nagar NEW DELHI Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato SOCIETY FOR APPLIED STUDIES India Contributo UE Nessun dato Indirizzo 108 Maniktala Main Road KOLKATA Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT Francia Contributo UE Nessun dato Indirizzo 213 Rue La Fayette PARIS Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato