Objective
This interdisciplinary research aims to combine pathogen and immune dynamics with met population theory. It will form an important link between the research on spatial population dynamics and the intra-host dynamics of infectious diseases such as human immunodeficiency virus (HIV); polyomavirus type BK (BKV), hepatitis B (HBV) and hepatitis C (HCV). The goal of this research project is to address the following questions:
(A) Can different immune mechanisms contribute to level-level persistence of a viral disease by changing complex local dynamics and thereby decreasing synchrony in the dynamics of different local virus populations?
(B) Does subdivision of a large population of viruses into a large number of small subpopulations by different immune mechanisms increase or decrease eradication time in vivo?
(C) What are the implications for the evolution of immunology memory (B-cells and T-cells)? (D) How do qualitatively different sub-compartments of infected cells contribute to long-term stability and persistence of a viral infection? A natural conceptual framework to answer the above questions comes from ecology, where it is known as \"level dynamics\". The proposed research project has the potential to lead to important insights in the pathogenesis of HIV and the design of therapeutics and vaccines. It further may help to preserve the function of transplanted organs in kidney recipients suffering from BKV infection, which not only increases the quality y of life of those patients, but also reduces the demand of donor organs. The research project is interjectorily and has the potential to lead an exchange of knowledge between ecology and the life sciences. With respect to the transfer of knowledge within the European Community the project will allow me to learn how to apply models and modelling techniques from theoretical ecology to study the dynamics of infectious diseases on a microscopic spatial scale.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases DNA viruses hepatitis B
- medical and health sciences health sciences infectious diseases RNA viruses hepatitis C
- medical and health sciences basic medicine immunology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EGHAM, SURREY
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.