Objective
The detection of specific sequences of DNA is pivotal in the diagnosis of a number of infectious diseases, such as chlamydia. It is also important in detecting and identifying potential bio-warfare agents. Current methods of DNA detection typically involve laboratory based sample analysis, which is slow and costly. This proposal seeks to address these drawbacks by developing an alternative approach based on nanopore unzipping. In this method the current-time transient is recorded for a single molecule of dsDNA as it denatures and passes through a protein pore. The current as the DNA blocks the pore, as well as the time taken for the dsDNA to 'unzip' (denature) is characteristic of the DNA sequence, length and the presence of any modifications. The proiten pore itself must be suspended in a lipid bilayer across a nm-diameter orifice that acts as a platform. Whilst identification of DNA targets with nanopore unzipping is expected to be quick and efficient, the platforms typically used for such measurements (mainly silicates) are fragile and lack bio-compatibility. This proposal seeks to bring the power of nanopore unzipping outside of the laboratory through the development of a robust, ultra-stable, platform constructed from diamond. The research conducted during this proposal could lead to a commercially viable device capable of detecting and identifying DNA at the point need, for example in medical diagnostics in a hospital or identifying potential bio-warfare agents in the field of operation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences health sciences infectious diseases
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2013-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
CV4 8UW COVENTRY
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.